AIM: To explore feasibility and practicability of macula localization independent of macular morphological features. METHODS: A novel method was proposed to identify macula in fundus images by using structure label transfer. Its main idea was to match a processed image with the candidate images with known structures, and then transfer the structure label representing the macular to the processed image as a result of macula localization. In this way, macula localization couldn’t be influenced by lesion or other interference any more. RESULTS: The average success rate in four datasets was 98.18%. For accuracy, the average error distance in four datasets was 0.151 optic disc diameter (ODD). Even for severe lesion images, the proposed method can still maintain high success rate and high accuracy, e.g., 95.65% and 0.124 ODD in the case of STARE dataset, respectively, which indicated that the proposed method was highly robust and stable in the complicated situations. CONCLUSION: The proposed method can avoid the interference of lesion to macular morphological features in macula localization, and can locate macula with high accuracy and robustness, verifying its feasibility.