| Citation:Li S,Liu N,Lin L,Sun ED,Li JD,Li PK.Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration.Int J Ophthalmol 2018;11(6):970-975,doi:10.18240/ijo.2018.06.12 |
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| Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration |
| Received:October 03, 2017 Revised:February 05, 2018 |
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| DOI：10.18240/ijo.2018.06.12 |
| Key Words:Goji berry zeaxanthin early age-related macular degeneration |
| Fund Project:Supported by Special Foundation for Public Welfare Research of China (No.2013CZ-9). |
| Author | Institution |
| Shang Li |
Department of Ophthalmology, Beijing YouAn Hospital, Capital Medical University Beijing, Beijing, China |
| Na Liu |
Department of Ophthalmology, China Rehabilitation Research Center, Chinese Rehabilitation Science Institute, Capital Medical University, Beijing , China |
| Li Lin |
Research Center, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing , China |
| Er-Dan Sun |
Department of Ophthalmology, China Rehabilitation Research Center, Chinese Rehabilitation Science Institute, Capital Medical University, Beijing , China |
| Jian-Da Li |
Department of Ophthalmology, China Rehabilitation Research Center, Chinese Rehabilitation Science Institute, Capital Medical University, Beijing , China |
| Peng-Kun Li |
Department of Ophthalmology, China Rehabilitation Research Center, Chinese Rehabilitation Science Institute, Capital Medical University, Beijing , China |
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| Abstract: |
| AIM: To evaluate the efficacy of Goji berry supplementation on improving macular pigment, serum zeaxanthin levels and visual acuity in patients with early age-related macular degeneration (AMD).
METHODS: A total of 114 patients (aged from 51 to 92y, mean age 69.53±8.41y) with early AMD were enrolled in our prospective, randomized controlled study. The included patients were assigned randomly to the Goji group (n=57) with 25 g of Goji berries supplementation per day for 90d and the control group (n=57) with their normal diet for 90d. Macular pigment optical density (MPOD) was measured using heterochromatic flicker photometry (HFP). The levels of serum lutein (L)/zeaxanthin (Z) were analyzed using high-performance liquid chromatography (HPLC). MPOD, serum L/Z levels and best corrected visual acuity (BCVA) were recorded at baseline and 90d.
RESULTS: In the Goji group, there were no statistically significant differences in the serum L levels between the baseline (0.199±0.149 μmol/mL) and 90d (0.203±0.181 μmol/mL) (t=-0.186, P=0.850); however the serum Z levels were increased at 90d (0.101±0.087 μmol/mL) compared with those at the baseline (0.029±0.032 μmol/mL) (t=6.412, P<0.001). Patients treated with Goji berry for 90d showed an elevated MPOD (0.877±0.202 DU) from the baseline (0.731±0.205 DU) (t=-4.741, P=0.000). In contrast to the control group, the serum Z levels and MPOD were higher in the Goji group at 90d (both P<0.05). At 90d, patients with Goji berry supplementation had a relative decrease in BCVA (0.21±0.18 logMAR) compared with the baseline (0.27±0.20) (t=2.397, P=0.020).
CONCLUSION: Overall, daily supplementation with Goji berry for 90d improves MPOD by increasing serum Z levels rather than serum L levels in early AMD patients. Goji berry may be an effective therapeutic intervention for preventing the progression of early AMD. |
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