Citation:Li XX.A quantitative comparison of five optical coherence tomography angiography systems in clinical performance.Int J Ophthalmol 2018;11(11):1784-1795,doi:10.18240/ijo.2018.11.09
A quantitative comparison of five optical coherence tomography angiography systems in clinical performance
Received:May 14, 2018  Revised:July 06, 2018
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Key Words:optical coherence tomography angiography; devices; vessel valid visibility; motion artifacts; acquisition time
Fund Project:Supported by National Key Research and Development Program for Precision Medicine of China (No.2016YFC0904800).
Xin-Xin Li Department of Ophthalmology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai , China; Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai , China; 3Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai , China
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      AIM: To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVueTM, AngioPlexTM, Spectralis? OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT AngioTM.

    METHODS: Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm2 scan pattern (Spectralis OCTA for 3×3 mm2 scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance (ANOVA) with Bonferroni's post-test and Friedman test with Dunn's post-test were used to compare measurements.

    RESULTS: The age of the subjects was 28.19±5.55y (range, 23-49y). The spherical equivalent refraction was -2.55±1.84 D (range, 0.00 to -5.25 D). Significant difference was observed in the evaluation of vessel valid visibility (AngioVue the highest: 0.111±0.031 for 3×3 mm2 scan and 0.128±0.020 for 6×6 mm2 scan), number of motion artifacts (AngioVue the fewest: 0.778±1.086 for 3×3 mm2 scan and 0.333±0.620 for 6×6 mm2 scan) and acquisition time (AngioPlex the shortest: 8.537±1.921s for 3×3 mm2 scan and 8.298±1.741s for 6×6 mm2 scan; all P<0.001).

    CONCLUSION: There is poor agreement of measurements among systems. AngioVue provides images with the highest vessel valid visibility and the fewest motion artifacts. AngioPlex achieves the shortest acquisition.

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