Citation:Hu YX,He JR,Yang B,Huang X,Li YP,Zhou FQ,Xu XX,Zhong YL,Wang J,Wu XR.Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis.Int J Ophthalmol 2018;11(11):1814-1820,doi:10.18240/ijo.2018.11.13
Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis
Received:January 15, 2018  Revised:September 10, 2018
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DOI:10.18240/ijo.2018.11.13
Key Words:high myopia; degree centrality; functional magnetic resonance imaging; resting state
Fund Project:Supported by National Natural Science Foundation of China (No.81760179; No.81360151); Natural Science Foundation of Jiangxi Province (No.20171BAB205046); Jiangxi Province Education Department Key Foundation (No.GJJ160033); Health Development Planning Commission Science Foundation of Jiangxi Province (No.20185118).
                             
AuthorInstitution
Yu-Xiang Hu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Jun-Rong He Department of Quality Management Office, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou , Jiangxi Province, China
Bo Yang Department of Ophthalmology, Xinjiang People’s Hospital, Urumqi , Xinjiang Uygur Autonomous Region, China
Xin Huang Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Yu-Ping Li Department of Ophthalmology, Dongxiang People’s Hospital, Fuzhou , Jiangxi Province, China
Fu-Qing Zhou Department of Radiology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang , Jiangxi Province, China
Xiao-Xuan Xu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Yu-Lin Zhong Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
Jun Wang Second Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang , Jiangxi Province, China
Xiao-Rong Wu Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang , Jiangxi Province, China
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Abstract:
      AIM: To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method.

    METHODS: In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 healthy controls (17 males and 21 females), closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance.

    RESULTS: Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule (P<0.05). In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus (P<0.05). However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance (P>0.05).

    CONCLUSION: HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232325/
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