Citation:Yu SS,Zhao Y,Zhao H,Lin JY,Tang X.A retrospective study of 2228 cases with eyelid tumors.Int J Ophthalmol 2018;11(11):1835-1841,doi:10.18240/ijo.2018.11.16
A retrospective study of 2228 cases with eyelid tumors
Received:April 30, 2018  Revised:July 20, 2018
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DOI:10.18240/ijo.2018.11.16
Key Words:eyelid tumors; benign tumors; malignant tumor; basal cell carcinoma; sebaceous carcinoma; squamous cell carcinoma; melanocytic nevus
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Sha-Sha Yu Clinical College of Ophthalmology, Tianjin Medical University, Tianjin , China
Yun Zhao Tianjin Eye Hospital, Tianjin , China
Hong Zhao Tianjin Eye Hospital, Tianjin , China
Jin-Yong Lin Tianjin Eye Hospital, Tianjin , China
Xin Tang Clinical College of Ophthalmology, Tianjin Medical University, Tianjin , China; Tianjin Eye Hospital, Tianjin , China; Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin , China; Tianjin Eye Institute, Tianjin , China
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Abstract:
      AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

    METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location.

    RESULTS: Most eyelid tumors were epidermal in origin (1080, 48.5%), followed by miscellaneous (885, 39.7%) and adnexal tumors (263, 11.8%). Among all the tumors, 292 (13.1%) were malignant lesions, 1910 (85.7%) benign and 26 (1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells (60.0%), followed by adnexal cells (34.6%). The most common malignant tumors were basal cell carcinomas (56.5%) followed by sebaceous carcinoma (34.6%), squamous cell carcinomas (3.8%) and lymphoma/plasmocytoma (1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells (46.4%) followed by miscellaneous cell sources (45.2%), including melanocytic nevus (33.8%), seborrheic keratosis (13.7%), squamous cell papilloma (13.0%) and epidermal cysts (11.5%).

    CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338/
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