Citation:Jiang H,Wang LN,Liu Y,Li M,Wu M,Yin Y,Ma L,Wu CR.Physical activity and risk of age-related cataract.Int J Ophthalmol 2020;13(4):643-649,doi:10.18240/ijo.2020.04.18 |
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Physical activity and risk of age-related cataract |
Received:May 29, 2019 Revised:July 24, 2019 |
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DOI:10.18240/ijo.2020.04.18 |
Key Words:physical activity age-related cataract lens Meta-analysis |
Fund Project:Supported by the National Natural Science Foundation of China (No.81473059); the Natural Science Foundation of Shaanxi Province of China (No.2017JM8041); the China Postdoctoral Science Special Foundation (No.2015T81036). |
Author | Institution |
Hong Jiang |
First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an , Shaanxi Province, China; School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Li-Na Wang |
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Yan Liu |
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Ming Li |
Centre for Population Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia |
Min Wu |
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Yue Yin |
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Le Ma |
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China |
Chang-Rui Wu |
First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an , Shaanxi Province, China |
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Abstract: |
AIM: To summarize quantitatively the prospective association between physical activity and age-related cataract (ARC) risk.
METHODS: PubMed, Embase, Web of Science, and Cochrane Library were systematically searched for all relevant follow up studies until July 2019. Multivariable-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CIs) from individual studies were used to calculate the overall summary estimates. The dose-response relationship was assessed using generalized least-squares trend estimation.
RESULTS: Six prospective cohort studies, involving 19 173 cases in 6.2-12.1y follow up of 171 620 participants, were included in the analysis. Increased physical activity was significantly associated with reduced risk of ARC by 10% (RR: 0.90; 95%CI: 0.81, 0.99, P=0.04). Stratified analysis by assessment method for physical activity suggest that studies using metabolic equivalent (MET) per day tended to report a slightly stronger association with ARC (RR: 0.85; 95%CI: 0.81, 0.90, P<0.001) than studies which assessed activity by weekly activity (RR: 0.96; 95%CI: 0.89, 1.03, P=0.24). Dose-response analysis indicated that the risk of ARC decreased by 2% (RR: 0.98; 95%CI: 0.98, 0.99, P<0.001) for every 6 METs per day increase in activity.
CONCLUSION: The findings from this Meta-analysis provide additional evidence that increased physical activity is inversely associated with ARC risk dose-responsively. |
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