Citation:Jiang H,Wang LN,Liu Y,Li M,Wu M,Yin Y,Ma L,Wu CR.Physical activity and risk of age-related cataract.Int J Ophthalmol 2020;13(4):643-649,doi:10.18240/ijo.2020.04.18
Physical activity and risk of age-related cataract
Received:May 29, 2019  Revised:July 24, 2019
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DOI:10.18240/ijo.2020.04.18
Key Words:physical activity  age-related cataract  lens  Meta-analysis
Fund Project:Supported by the National Natural Science Foundation of China (No.81473059); the Natural Science Foundation of Shaanxi Province of China (No.2017JM8041); the China Postdoctoral Science Special Foundation (No.2015T81036).
                       
AuthorInstitution
Hong Jiang First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an , Shaanxi Province, China; School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Li-Na Wang School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Yan Liu School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Ming Li Centre for Population Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
Min Wu School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Yue Yin School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Le Ma School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Province, China
Chang-Rui Wu First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an , Shaanxi Province, China
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Abstract:
      AIM: To summarize quantitatively the prospective association between physical activity and age-related cataract (ARC) risk.

    METHODS: PubMed, Embase, Web of Science, and Cochrane Library were systematically searched for all relevant follow up studies until July 2019. Multivariable-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CIs) from individual studies were used to calculate the overall summary estimates. The dose-response relationship was assessed using generalized least-squares trend estimation.

    RESULTS: Six prospective cohort studies, involving 19 173 cases in 6.2-12.1y follow up of 171 620 participants, were included in the analysis. Increased physical activity was significantly associated with reduced risk of ARC by 10% (RR: 0.90; 95%CI: 0.81, 0.99, P=0.04). Stratified analysis by assessment method for physical activity suggest that studies using metabolic equivalent (MET) per day tended to report a slightly stronger association with ARC (RR: 0.85; 95%CI: 0.81, 0.90, P<0.001) than studies which assessed activity by weekly activity (RR: 0.96; 95%CI: 0.89, 1.03, P=0.24). Dose-response analysis indicated that the risk of ARC decreased by 2% (RR: 0.98; 95%CI: 0.98, 0.99, P<0.001) for every 6 METs per day increase in activity.

    CONCLUSION: The findings from this Meta-analysis provide additional evidence that increased physical activity is inversely associated with ARC risk dose-responsively.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137704/
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