Citation:Huang YM, Zhang L, Liang J, Yuan RD. Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept. Int J Ophthalmol 2020;13(6):1009-1012,doi:10.18240/ijo.2020.06.23
Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept
Received:March 08, 2019  Revised:February 12, 2020
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DOI:10.18240/ijo.2020.06.23
Key Words:vasohibin  ocular neovascularization  retinal neovascularization
Fund Project:Supported by the National Basic Research of China (No.81600758).
           
AuthorInstitution
Yan-Ming Huang Xinqiao Hospital of Army Medical University, Chongqing , China
Li Zhang Xinqiao Hospital of Army Medical University, Chongqing , China
Jin Liang Xinqiao Hospital of Army Medical University, Chongqing , China
Rong-Di Yuan Xinqiao Hospital of Army Medical University, Chongqing , China
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Abstract:
      Ischemic and neovascular diseases are one of the most difficult ocular diseases to deal with nowadays. Redundancy, poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades. After VEGF was found to be a primary factor in promoting retinal angiogenesis, intravitreal injection of anti-VEGF drugs has been the first-line treatment. Whereas, some patients are refractory to this therapy and problems of economic burden, local complications and adverse effects promote researches into other possible targets. The vasohibin (VASH) family is a newly-investigated factor in modulating ocular angiogenesis. The family includes VASH1 and VASH2, which show opposite effects of inhibiting and accelerating angiogenesis respectively. Positive results have been reported in cellular and animal experiments. With further researches, it can be a promising future target of treating ocular neovascular diseases.
PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270267/
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