Citation:Qi LS,Yao L,Wang XF,Zhao J,Liu Y,Wu TY,Yang QH,Zhao C,Zou ZK.Relative peripheral refraction and its role in myopia onset in teenage students.Int J Ophthalmol 2022;15(7):1108-1115,doi:10.18240/ijo.2022.07.10
Relative peripheral refraction and its role in myopia onset in teenage students
Received:January 21, 2021  Revised:April 27, 2022
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DOI:10.18240/ijo.2022.07.10
Key Words:relative peripheral hyperopia  peripheral refraction  incident myopia  schoolchildren
Fund Project:Supported by National Natural Science Foundation of China (No.81800854); Joint Innovation Project of National Defense Technology Innovation Zone (No.20-163-15-ZT-001-001-10); Efficiency Improvement Project of Air Force Medical University (No.2021HKYX24).
                          
AuthorInstitution
Lin-Song Qi Department of Ophthalmology, Air Force Medical Center, Beijing , China
Lu Yao Department of Ophthalmology, Air Force Medical Center, Beijing , China
Xue-Feng Wang Department of Physical Examination, Cadet Bureau of PLA Air Force, Beijing , China
Jin Zhao Department of Ophthalmology, Air Force Medical Center, Beijing , China
Yong Liu Department of Ophthalmology, Air Force Medical Center, Beijing , China
Teng-Yun Wu Department of Ophthalmology, Air Force Medical Center, Beijing , China
Qing-Hong Yang Department of Ophthalmology, Air Force Medical Center, Beijing , China
Chen Zhao Department of Ophthalmology, Air Force Medical Center, Beijing , China
Zhi-Kang Zou Department of Clinic and Research, Air Force Medical Center, Beijing , China
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Abstract:
      AIM: To characterize peripheral refraction and its relationship with myopia development in a selected group of male teenage Chinese students.

    METHODS: This 2-year prospective cohort study randomly enrolled 85 non-myopic boys (age, 14-16y) from the Experimental Class of Air Force in China. Cycloplegic peripheral refraction was examined at 0°, ±10°, and ±20° along the horizontal visual field in the right eye at the baseline and 2-year follow-up.

    RESULTS: The incidence of myopia at the 2-year follow-up was 15.29% (13/85). The baseline central refraction (CR) and peripheral refraction at ±10° were significantly lower in students who developed myopia than in those who did not (P<0.05). Relative peripheral refraction (RPR) did not differ between students with and without myopia (P>0.05). At the 2-year follow-up, the RPR at ±10° and 20° nasal was significantly more hyperopic in the myopic group than in the non-myopic group. Multiple linear regression analysis indicated that the change in CR was significantly correlated with the changes in RPR at 20° nasal, 10° nasal, and 20° temporal. Multivariate Logistic regression analysis indicated that the baseline CR [odds ratio (OR): 0.092, 95% confidence interval (CI): 0.012-0.688, P=0.020] and the baseline RPR at 10° nasal (OR: 0.182, 95%CI: 0.042-0.799, P=0.024) were significantly correlated with incident myopia (Omnibus test, χ2=10.20, P=0.006).

    CONCLUSION: CR change is significantly correlated with changes in RPR, and students who develop myopia have more relative peripheral hyperopia. More baseline CR and relative peripheral hyperopia at 10° nasal are protective of myopia onset.

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