Citation:Pan SY,Wang YZ,Li J,Zhang XH,Wang J,Zhu XP,Xiao XH,Liu JT.Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children.Int J Ophthalmol 2022;15(7):1122-1127,doi:10.18240/ijo.2022.07.12
Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children
Received:July 08, 2021  Revised:September 09, 2021
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DOI:10.18240/ijo.2022.07.12
Key Words:atropine sulphate eye gel  myopia  spherical equivalent  axial length
Fund Project:Supported by Shaanxi Province Social Development and Technology of Research Project (No. 2020SF-274; No.2014K11-03-07-05); Xi’an Science and Technology Project (No.20YXYJ0008-6).
                       
AuthorInstitution
Shi-Yin Pan Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Pronvince, China; Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi’an , Shaanxi Province, China
Yang-Zheng Wang Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi’an , Shaanxi Province, China
Jun Li Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi’an , Shaanxi Province, China
Xue-Hui Zhang Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China
Jin Wang Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China
Xiu-Ping Zhu Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi’an , Shaanxi Province, China
Xiang-Hua Xiao Shaanxi Provincial Clinical Research Center for Ophthalmology, Xi’an First Hospital, Xi’an , Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi’an , Shaanxi Province, China
Jun-Tian Liu Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an , Shaanxi Pronvince, China
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Abstract:
      AIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in children.

    METHODS: Totally 185 children aged 6-12y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine group (n=125) received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily. The control group included 60 matched children without drug intervention during the same period. The spherical equivalent and axial length was recorded at baseline and the sixth month of treatment. The efficacy was evaluated by the change of the spherical equivalent and axial length. Adverse events were also recorded.

    RESULTS: The average spherical equivalent and axial length at baseline were not statistically significant between the atropine group (-1.64±0.80 D, 24.13±0.76 mm) and the control group (-1.59±0.94 D, 24.06±0.77 mm, P>0.05). After 6mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group (-0.27±0.33 vs -0.60±0.35 D, P<0.001), with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group (0.19±0.14 vs 0.26±0.14 mm, P<0.001), with a relative reduction of 26.9% in axial length. The 84.4% and 38.4% of the eyes progressed by less than 0.50 D and remained stable in the atropine group, compared with 51.7% and 4.2% in the control group. No adverse events were observed.

    CONCLUSION: Atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment.

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