Citation:Ma H,Gao Y,Li JM,Bao YK,Nie C,Yin P,Lyu X,Ding XY,Lu R.Analysis of retinal vasculature changes in indirect traumatic optic neuropathy using optic coherence tomography angiography.Int J Ophthalmol 2022;15(8):1344-1351,doi:10.18240/ijo.2022.08.18
Analysis of retinal vasculature changes in indirect traumatic optic neuropathy using optic coherence tomography angiography
Received:January 17, 2021  Revised:August 20, 2021
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DOI:10.18240/ijo.2022.08.18
Key Words:optic coherence tomography angiography  indirect traumatic optic neuropathy  macular capillary density  retinal nerve fiber layer thickness  optic nerve head peripapillary vessel density
Fund Project:Supported by the High-level Hospital Construction Project (No.303010406); Natural Science Foundation of Guangdong Province, China (No.2019A1515010361).
                          
AuthorInstitution
Huan Ma State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Yang Gao State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Jin-Miao Li State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Yue-Kun Bao State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Cong Nie State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Pan Yin State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Xi Lyu State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Xiao-Yan Ding State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
Rong Lu State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou , Guangdong Province, China
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Abstract:
      AIM: To assess the retinal vasculature alterations in indirect traumatic optic neuropathy (ITON) patients following craniofacial trauma by optic coherence tomography angiography (OCTA).

    METHODS: Patients diagnosed of monocular ITON were recruited from August 2016 to May 2020. OCTA was performed using the AngioVue OCT-A system for two cube scans centered at the optic nerve head and fovea. OCTA data included thicknesses of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC), as well as proportion of capillary perfusion and data were analyzed for correlation with post-injury timepoints: within 7, 8-30, 31-90, and 91-365d.

    RESULTS: A total of 73 ITON patients were studied. Significant thinning of RNFL and GCC layers and attenuation of microvascular perfusion were observed in ITON eyes as compared to contralateral unaffected eyes (for most of the analyzed sectors and quadrants, P<0.05). Without respect to surgical intervention and vision recovery, the decrease in retinal layer thicknesses and microvascular perfusion was time-dependent, and most significant within three months (P<0.001).

    CONCLUSION: ITON presents with time-dependent thinning of retinal layers and attenuation of microvasculature, indicating possible degeneration of retinal ganglion cells due to reduced retinal blood supply.

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