Citation:Cui B,Jia HZ,Gao LX,Dong XF.Risk of anxiety and depression in patients with uveitis: a Meta-analysis.Int J Ophthalmol 2022;15(8):1381-1390,doi:10.18240/ijo.2022.08.23
Risk of anxiety and depression in patients with uveitis: a Meta-analysis
Received:May 21, 2021  Revised:October 11, 2021
Email this Article  Add to Favorites  Print
DOI:10.18240/ijo.2022.08.23
Key Words:anxiety  depression  uveitis  Meta-analysis
Fund Project:
           
AuthorInstitution
Bei Cui Senior Department of Ophthalmology, the Third Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing , China
Hong-Zhen Jia Senior Department of Ophthalmology, the Third Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing , China
Li-Xiong Gao Senior Department of Ophthalmology, the Third Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing , China
Xiao-Fei Dong Department of Ophthalmology, No.967 Hospital of the Joint Logistics Support Force of the Chinese PLA, Dalian , Liaoning Province, China
Hits: 116
Download times: 43
Abstract:
      AIM: To quantitatively evaluate the risk of anxiety and depression in patients with uveitis via performing a Meta-analysis.

    METHODS: Three electronic database (PubMed, Embase, and Cochrane Library databases) were searched for studies recording data about uveitis and anxiety as well as depression simultaneously up to January 2021. The incidence rate and standard mean difference (SMD) with a 95% confidence interval (95%CI) were calculated to analyse the association using random-effects models based on heterogeneity tests.

    RESULTS: In total, 12 observational studies containing 874 patients with uveitis were included. The results showed that there was a significant association between uveitis and anxiety (SMD=0.97, 95%CI: 0.39 to 1.54, P=0.0009) and depression (SMD=0.79, 95%CI: 0.51 to 1.07, P<0.00001). The overall morbidities of anxiety and depression in patients with uveitis were 39% and 17%, respectively. With subgroup analysis, the heterogeneity actually came from different kinds of uveitis. Specifically, the incidence rates of both anxiety and depression were relatively low in patients with anterior uveitis (33% and 15%), moderate in patients with infectious uveitis (46% and 22%), and high in patients with unspecified uveitis (59% and 35%).

    CONCLUSION: It is preliminarily indicated that patients with uveitis may have a high risk of anxiety and depression. Ophthalmologists and psychologists should pay more attention to the psychological state when dealing with patients with uveitis. Further high-quality studies with detailed direct data are needed to draw more precise conclusions.

Supplementary Material
PDF Fulltext  Download reader  View/Add Comment