Citation:Liu JC,Zhang CL,Dong KY,Li MJ,Sun SG,Li CR.Advances in the research of plant-derived natural products against retinoblastoma.Int J Ophthalmol 2022;15(8):1391-1400,doi:10.18240/ijo.2022.08.24
Advances in the research of plant-derived natural products against retinoblastoma
Received:June 01, 2021  Revised:November 24, 2021
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DOI:10.18240/ijo.2022.08.24
Key Words:plant-derived  retinoblastoma  apoptosis  cell cycle  drug resistance
Fund Project:Supported by the Scientific Research Fund of Jiangxi Education Department (No.GJJ211224); the Joint Key Project of Yunnan Universities (No.202001BA070001-007).
                 
AuthorInstitution
Jing-Chen Liu Department of Ophthalmology, Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine, the Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang , Jiangxi Province, China; School of Clinical Medicine, Dali University, Dali , Yunnan Province, China; School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang , Jiangxi Province, China
Chun-Li Zhang Department of Ophthalmology, General Hospital of Southern Theatre Command, Guangzhou , Guangdong Province, China
Kai-Ye Dong Department of Ophthalmology, the First Affiliated Hospital of Dali University, Dali , Yunnan Province, China
Ming-Jun Li School of Clinical Medicine, Dali University, Dali , Yunnan Province, China
Shu-Guang Sun School of Clinical Medicine, Dali University, Dali , Yunnan Province, China; Department of Endocrinology, the First Affiliated Hospital of Dali University, Dali , Yunnan Province, China
Cai-Rui Li School of Clinical Medicine, Dali University, Dali , Yunnan Province, China; Department of Ophthalmology, the First Affiliated Hospital of Dali University, Dali , Yunnan Province, China
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Abstract:
      Retinoblastoma (RB) is a highly aggressive ocular tumor, and due to socioeconomic and medical constraints, many children receive treatment only in the metaphase and advanced clinical stages, resulting in high rates of blindness and disability. Although several approaches exist in the treatment of RB, some children with the disease do not have satisfactory results because of various factors. Plant-derived natural products have shown definite therapeutic effects in the treatment of various tumors and are also widely used in the study of RB. We review plant-derived natural products used in the study of anti-RB to provide ideas for the clinical application of these drugs and the development of new therapeutic drugs.
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