Citation:Meng FX,Yue H,Yuan YQ,Zhang R,Yuan YF,Bi YW,Qian J.Lacrimal sac lymphoma: a case series and literature review.Int J Ophthalmol 2022;15(10):1586-1590,doi:10.18240/ijo.2022.10.04
Lacrimal sac lymphoma: a case series and literature review
Received:September 25, 2021  Revised:June 20, 2022
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DOI:10.18240/ijo.2022.10.04
Key Words:lacrimal sac tumor  lacrimal drainage apparatus  non-epithelial lacrimal sac tumor  lymphoma  mucosal-associated lymphoid tissue lymphoma
Fund Project:Supported by the National Natural Science Foundation of China (No.81970835); the Science and Technology Commission of Shanghai Municipality, China (No.20Y11911200).
                    
AuthorInstitution
Feng-Xi Meng Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
Han Yue Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
Yi-Qun Yuan Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
Rui Zhang Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
Yi-Fei Yuan Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
Ying-Wen Bi Department of Pathology, Eye & ENT Hospital of Fudan University, Shanghai , China
Jiang Qian Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai , China; NHC Key Laboratory of Myopia, Fudan University, Shanghai , China
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Abstract:
      AIM: To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region.

    METHODS: Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed.

    RESULTS: There were five mucosal-associated lymphoid tissue (MALT) lymphomas, one diffused large B-cell lymphoma, one NK/T cell lymphoma, and one mantle cell lymphoma. All eight patients represented symptoms of epiphora with swelling in the lacrimal sac for a certain period of time and showed no signs of systemic involvement at the first time of clinical visits. They had received either chemotherapy or radiotherapy after surgery. Long-term follow-up (from 11 to 220mo) showed that, except one patient with MALT lymphoma died for unknown reasons at 104mo after surgery, the other 7 patients were all alive with no signs of local recurrence, neither in other organs.

    CONCLUSION: Non-epithelial malignant tumors of the lacrimal sac are rare and lymphoma is the major subtype.

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