Citation:Wang YH,Zhong J,Li XM.Age-related changes of lens thickness and density in different age phases.Int J Ophthalmol 2022;15(10):1591-1597,doi:10.18240/ijo.2022.10.05
Age-related changes of lens thickness and density in different age phases
Received:October 04, 2021  Revised:February 14, 2022
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DOI:10.18240/ijo.2022.10.05
Key Words:lens thickness  lens density  age  staged growth
Fund Project:Supported by the National Science Foundation of Beijing Municipality (No.7202229).
        
AuthorInstitution
Yin-Hao Wang Department of Ophthalmology, Peking University Third Hospital, Beijing 10091, China; Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 10091, China
Jing Zhong Education Department, Peking University Third Hospital, Beijing 10091, China
Xue-Min Li Department of Ophthalmology, Peking University Third Hospital, Beijing 10091, China; Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 10091, China
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Abstract:
      AIM: To explore the changes in lens thickness and density with age.

    METHODS: A Chinese population-based retrospective study was performed. A total of 497 individuals (490 right eyes and 495 left eyes), ranging from 3 to 69 years old were included. Lens images obtained from IOL Master 700 were used to measure lens thickness and density. Piecewise regression model was chosen to illustrate the relationship of lens thickness and density with age.

    RESULTS: The proportion of people aged 3-18, 19-40, over 40 was 38.6%, 50.9% and 10.5% respectively. The whole lens thickness decreased with age during the first 7 years of life, kept stable from 8 to 16 years old, and then increased at the rate of about 27 ?m per year. The thickness of the lens cortex and nucleus tended to decrease first and then increase with age, which was dependent on age stages. The whole lens density also decreased with age until 7 years old. The increasing rate of lens density was different in different age groups. The whole lens density increased rapidly from 7 to 22 years old and slowed down after 22 years old. Similarly, the changing tendency of lens cortical and nuclear density differed in different age phases.

    CONCLUSION: Both lens thickness and density are significantly associated with age, whereas they do not change linearly with age. Moreover, it is necessary to increase the population over 40 years old and conduct further research.

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