Citation:He J,Lin YY,Chen J,Sun B,Wang YH,Jiang DD,Liu LJ,Lin SD,Chen YY.Association of sleep quality with myopia based on different genetic risk levels.Int J Ophthalmol 2022;15(10):1657-1664,doi:10.18240/ijo.2022.10.14
Association of sleep quality with myopia based on different genetic risk levels
Received:December 04, 2021  Revised:February 25, 2022
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DOI:10.18240/ijo.2022.10.14
Key Words:sleep quality  genetic risk score  myopia  children
Fund Project:Supported by the National Natural Science Foundation of China (No.81873683).
                          
AuthorInstitution
Juan He School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Yao-Yao Lin The Eye Hospital, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Jie Chen The Eye Hospital, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Bing Sun School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Yan-Hui Wang School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Dan-Dan Jiang The Eye Hospital, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Lin-Jie Liu The Eye Hospital, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Shu-Dan Lin School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
Yan-Yan Chen The Eye Hospital, Wenzhou Medical University, Wenzhou , Zhejiang Province, China
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Abstract:
      AIM: To analyse the association of sleep quality with myopia under different genetic risk (GR) levels.

    METHODS: A cross-sectional survey of students aged 9-14y in Wenzhou, China, was conducted. Refraction without cycloplegia and ocular parameters were measured. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Seventeen single nucleotide polymorphisms (SNPs) were replicated by association analysis and used to compute the GR score (GRS). Possible confounders were assessed by a questionnaire that collected information about the children and their parents. Generalized linear models were used to analyse the sleep quality, the GR, and their interaction effects on the risk of myopia.

    RESULTS: Out of 1354 children included in this study, 353 (26.07%) had sleep disturbances. The GRS ranged from 4.49 to 12.89 with a mean of 7.74±1.23, and the participants were divided into a low GR group, a moderate GR group and a high GR group according to the GRS quartile. In the generalized linear model, the children with sleep disturbances and high GR had a higher risk of myopia than those without sleep disturbances and with low GR (OR=1.59, 95%CI: 1.12-2.25; OR=1.88, 95%CI: 1.23-2.88, respectively). Compared to those with low GR and SDs, children with high GR with or without SDs had a higher risk of myopia (OR=4.88, 95%CI: 2.03-11.71; OR=1.70, 95%CI: 1.06-2.72, respectively).

    CONCLUSION: The prevalence of sleep disturbances in elementary school students in Wenzhou was 26.07%. There is a significant interaction between sleep disturbances and a high GR of myopia, suggesting that a high GR of myopia may increase children’s sensitivity to sleep disturbances. This study indicates that children with a high GR of myopia need to achieve adequate sleep duration and excellent sleep quality.

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