Citation:Ibrahim NMS,Hashem HA,Helal AY.Evaluation of the acute effect of Sildenafil citrate onvisual function in patients with early -stage agerelated macular degeneration.Int J Ophthalmol 2008;1(1):70-73,doi:
Evaluation of the acute effect of Sildenafil citrate onvisual function in patients with early -stage agerelated macular degeneration
Received:October 22, 2007  Revised:January 05, 2008
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Key Words:Sildenafil citrate  visual function  age related macular degeneration
Fund Project:Evaluation of the acute effect of Sildenafil citrate on visual function in patients with early-stage age related macular degeneration. Int J Ophthalmol
        
AuthorInstitution
Neveen Mostafa Sabra Ibrahim Department of Physiological Optics, Research Institute of Ophthalmology, Giza, Egypt
Hisham Aly Hashem Department of Ophthalmology,Research Institute of Ophthalmo- logy,Giza, Egypt
Ahmed Youssef Helal Department of Ophthalmology,Research Institute of Ophthalmo- logy,Giza, Egypt
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Abstract:
      To assess the effect of a single dose of Sildenafil citrate on the visual function in men with early-stage age related macular degeneration(AMD).

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    METHODS: Forty men (mean age 71, range from 55-86 years)with early-stage AMD were prospectively randomized to receive either placebo or Sildenafil citrate (Viagra; Pfizer Inc, New York, NY) 100mg as a single oral dose. Subjects underwent visual acuity, Amsler grid and color discrimination in each eye before and at specific intervals within 9 hours after dosing.

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    RESULTS: Compared with placebo, no pattern of errors were evident in any visual function test following Sildenafil administration. No statistically or clinically relevant changes from baseline were observed in visual acuity or color discrimination. No clinically relevant changes were observed in the Amsler grid. Sildenafil treatment was associated with transient mild or moderate headache and flushing.

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    CONCLUSION: A single 100mg dose of Sildenafil was well tolerated and produced no significant acute visual effects in a sample of men with early-stage AMD.

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