Citation:E V. Giordano,Sergio E. Hernandez-Da Mota,Tania N. Adabache-Guel,Armando Castillejos-Chevez,Sonia Corredor-Casas,Samantha M. Salinas-Longoria,Rafael Romero-Vera,Juan M. Jimenez-Sierra,Jose L. Guerrero-Naranjo,Virgilio Morales-Canton.Safety of intravitreal quinupristin/dalfopristin in an animal model.Int J Ophthalmol 2016;9(3):373-378,doi:10.18240/ijo.2016.03.08
Safety of intravitreal quinupristin/dalfopristin in an animal model
Received:January 10, 2015  Revised:July 29, 2015
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DOI:10.18240/ijo.2016.03.08
Key Words:endophthalmitis  quinupristin/dalfopristin  retinal toxicity
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Veronica E. Giordano Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Sergio E. Hernandez-Da Mota Ophthalmology Service, Clinica David, Boulevard García de León 598, Nueva Chapultepec, Morelia, Michoacán 58280, Mexico
Tania N. Adabache-Guel Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Armando Castillejos-Chevez Department of Ophthalmology, Glaucoma Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Sonia Corredor-Casas Department of Ophthalmology, Pathology Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Samantha M. Salinas-Longoria Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Rafael Romero-Vera Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Juan M. Jimenez-Sierra Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Jose L. Guerrero-Naranjo Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
Virgilio Morales-Canton Department of Ophthalmology, Retina and Vitreous Service, Asociacion para Evitar la Ceguera en Mexico, Vicente García Torres 46, Coyoacán, Barrio San Lucas, Mexico City 04030, Mexico
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Abstract:
      AIM: To determine whether different intravitreal doses of quinupristin/dalfopristin lead to electroretinographic or histological changes in the rabbit retina over one month period after injection.

    METHODS: Eighteen New Zealand white rabbits were divided into three treatment groups (groups 1 to 3) and different intravitreal doses of quinupristin/dalfopristin were tested in each group. The right eye was injected with the drug and the left eye received intravitreal injection of 5% dextrose water and served as control eye. The doses delivered to each group were 0.1 mg/0.1 mL, 1 mg/0.1 mL and 10 mg/0.1 mL. Simultaneous, bilateral, dark-adapted electroretinography and clinical images of both eyes were obtained in all groups before injection (baseline) and after 7, 14, 21 and 28d, followed by enucleation for histological examination.

    RESULTS: Subjects in the group 1 showed no signs of toxicity in the electroretinogram when compared with groups 2 and 3 (Kruskall-Wallis test, P=0.000). By day 7, no electrical response to light stimuli was recorded in the treated eyes in groups 2 and 3, consistent with severe damage due to retinal toxicity. Light microscopy revealed no significant histopathological changes in the group 1, while rabbits in groups 2 and 3 had signs of granulomatous inflammation in most cases.

    CONCLUSION: Intravitreal 0.1 mg/0.1 mL doses of quinupristin/dalfopristin do not lead to electroretinographic or histological signs of retinal toxicity compared with 1 mg/0.1 mL and 10 mg/0.1 mL in this rabbit model.

PMC FullText Html:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844051/
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