Citation:Luo WJ,Zhang WF.The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review.Int J Ophthalmol 2019;12(2):312-323,doi:10.18240/ijo.2019.02.20
The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review
Received:April 29, 2018  Revised:August 02, 2018
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DOI:10.18240/ijo.2019.02.20
Key Words:mean platelet volume  platelet distribution width  neutrophil to lymphocyte ratio  platelet-lymphocyte ratio  diabetic retinopathy
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Wen-Juan Luo Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou , Gansu Province, China
Wen-Fang Zhang Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou , Gansu Province, China
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Abstract:
      AIM: To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR).

    METHODS: We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference (SMD) calculated with confidence interval (CI) of 95% was used to estimate the values of those indices.

    RESULTS: A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus (T2DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR (SMD=0.67; 95%CI: 0.36 to 0.98; SMD=0.51; 95%CI: 0.27 to 0.75; SMD=0.77; 95%CI: 0.49 to 1.05 and SMD=1.18; 95%CI: 0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR.

    CONCLUSION: MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376234/
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