Citation:W P. MacIntosh,S. Vijay Kumar,V.R. Saravanan,Virna M. Shah.Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography.Int J Ophthalmol 2020;13(1):120-123,doi:10.18240/ijo.2020.01.17
Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography
Received:March 29, 2019  Revised:October 22, 2019
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DOI:10.18240/ijo.2020.01.17
Key Words:optic neuritis  non-arteritic ischemic optic neuropathy  optical coherence tomography  ganglion cell layer
Fund Project:Supported by Vision Research National Eye Institute (NEI) P30 EY001792; Unrestricted Research to Prevent Blindness (RPB) Departmental Grant.
           
AuthorInstitution
Peter W. MacIntosh Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL 60612, USA
S. Vijay Kumar Neuro-Ophthalmology Service, Aravind Eye Hospital, Coimbatore , India
V.R. Saravanan Neuro-Ophthalmology Service, Aravind Eye Hospital, Coimbatore , India
Virna M. Shah Neuro-Ophthalmology Service, Aravind Eye Hospital, Coimbatore , India
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Abstract:
      AIM: To elucidate the changes of different ganglion cell layer (GCL) thinning patterns between the optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION).

    METHODS: A prospective, observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography.

    RESULTS: Thinning on optical coherence tomography in the NAION group occurs as early as 11d after symptomatic onset of vision loss and follows an altitudinal pattern. The mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7 μm in the NAION cohort compared to controls of 0.8 μm (P=0.032), but not significant in the ON group compared to controls with both groups measuring 1.1 μm. Global thinning was significant for the ON group compared to controls at 7.2 μm (P=0.011) but not the NAION group compared to controls at 1.35 μm.

    CONCLUSION: These findings suggest that future treatments for NAION should be given early, and possibly before 11d in order to prevent GCL and irreversible vision loss.

PMC FullText Html:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942958/
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