Basic Research

The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

小鼠玻璃体腔注射辛伐他汀的眼毒性和药代动力学

Dennis Y. Tse, Seong Jae Kim, Inyoung Chung, Feng He, Theodore G. Wensel, Samuel M. Wu

 2017;10(9):1361-1369  DOI:10.18240/ijo.2017.09.05

【Recommended reason】The authors describe the ocular toxicity and pharmacokinetics of intravitreally injected Simvastatin, a drug that is potentially beneficial to patients with a broad range of disorders related to retinal degeneration. These findings are likely to be of interest to clinicians and researchers focused on the treatment of a variety of ocular diseases.

【推荐理由】 作者阐述了玻璃体腔内应用辛伐他汀的眼毒性和药代动力学，文中指出辛伐他汀对于大部分视网膜变性相关疾病具有潜在的益处，这些发现可能引起眼科临床医生和研究人员的兴趣。

 http://www.ijo.cn/en_publish/2017/9/20170905.pdf

Analysis of proteomic differences between liquefied after-cataracts and normal lenses using two-dimensional gel electrophoresis and mass spectrometry

二维凝胶电泳及质谱分析液化性后发性白内障和正常晶状体的蛋白质组差异

Jia-Jia Ge, Yu-Sen Huang

2017,10(9):1344-1348  DOI：10.18240/ijo.2017.09.02

【Recommended reason】The study adopted 2-DE to investigate proteomic differences between liquefied after-cataracts and normal lenses, and the results showed that in the liquefied after-cataracts, the filensin, beta-crystallin B1, and gamma-crystallin D were decreased, therefore those proteins may play an important role in the development of liquefied after-cataracts.

【推荐理由】 文章通过二维凝胶电泳及质谱分析液化性后发性白内障和正常晶状体的蛋白质组差异，发现在液化性后发性白内障中，晶状体丝蛋白，β晶体蛋白B1和γ晶状体蛋白D都有降低，由此看出这些蛋白在液化性后发性白内障的发展过程中起着重要作用。
http://www.ijo.cn/en_publish/2017/9/20170902.pdf

Clinical Research

Influence of corneal power on circumpapillary retinal nerve fiber layer and optic nerve head measurements by spectral-domain optical coherence tomography

通过频域光学相干断层扫描分析角膜屈光力对视盘周围视网膜神经纤维层和视盘测量的影响

Kazunori Hirasawa, Nobuyuki Shoji

2017,10(9):1385-1391   DOI：10.18240/ijo.2017.09.09

【Recommended reason】This study evaluate the influence of corneal power on circumpapillary retinal nerve fiber layer (cpRNFL) and optic nerve head (ONH) measurements by spectral-domain optical coherence tomography (SD-OCT). The results indicated that, the ocular magnification should be corrected by considering both the axial length and corneal power. However, the effect of corneal power changes on cpRNFL thickness and ONH topography are small when compared with those of the axial length.

【推荐理由】该研究利用频域光学相干断层扫描(SD-OCT)，评估角膜屈光力对视盘周围视网膜神经纤维层和视盘测量的影响。结果表明，眼球成像可通过眼轴和角膜屈光力进行矫正。然而，与眼轴相比，角膜屈光力变化对视盘周围视网膜神经纤维层和视盘测量的影响较小。

http://www.ijo.cn/en_publish/2017/9/20170909.pdf

Review

The role of elastic fibers in pathogenesis of conjunctivochalasis

弹性纤维在结膜松弛症发病机制中的作用

Jing-Yun Gan, Qing-Song Li, Zhen-Yong Zhang, Wei Zhang, Xing-Ru Zhang

2017,10(9):1465-1473   DOI：10.18240/ijo.2017.09.21

【Recommended reason】After analysis of the literature, the vast majority of the factors related to the pathogenesis of conjunctivochalasis ultimately pointed to abnormal elastic fibers. This paper hypothesizes that elastic fibers play an important role in the pathogenesis of conjunctivochalasis. Studies on the mechanism of synthesis, degradation of elastic fibers are helpful to clarify the pathogenesis of the disease and to find effective treatment methods.

【推荐理由】 作者通过对文献的分析，发现大量与结膜松弛症发病原理相关的因素与弹性纤维异常有关，因此推测弹性纤维在结膜松弛症发病机制中有着重要的作用，同时提出研究弹性纤维的合成及其降解将有利于阐明结膜松弛症发病原理并找到有效的治疗方法。
http://www.ijo.cn/en_publish/2017/9/20170921.pdf

Meta-Analysis

Systematic review and Meta-analysis comparing modified cross-linking and standard cross-linking for progressive keratoconus

改良角膜胶原交联和常规角膜交联治疗进展期圆锥角膜的系统回顾和Meta分析

Yang Liu, Yi Liu, Ying-Nan Zhang, Ai-Peng Li, Jing Zhang, Qing-Feng Liang, Ying Jie, Zhi-Qiang Pan

2017,10(9):1419-1429   DOI：10.18240/ijo.2017.09.15

【Recommended reason】In this work, the authors compared modified cross-linkings to standard cross-linking in halting progressive keratoconus through Meta-analysis. Standard cross-linking was more favorable at halting the progression of keratoconus, but visual acuity improvement showed comparable results between modified cross-linkings and standard cross-linking. Modified cross-linkings are more suitable for pediatrics regarding epithelium-on and short duration, and trans-epithelial cross-linkings could be carried out for patients with cornea thickness less than 400 µm due to its shallower depth of demarcation line. It is meaningful for clinical practitioner to choose optimal cross-linking for their patients in their own clinical settings.

【推荐理由】 作者通过Meta分析比较了改良角膜胶原交联和常规交联治疗进展期圆锥角膜的疗效。常规角膜胶原交联常用于治疗进展期圆锥角膜，但改良角膜胶原交联也可以获得相似的术后视力。改良交联因为保留了角膜上皮及较短的恢复时间，更适用于儿童患者，并且跨上皮角膜交联因为其治疗界线较浅，可用于角膜厚度小于400 µm的患者。这些结果对于临床医生选择合适的交联方法具有指导意义。

http://www.ijo.cn/en_publish/2017/9/20170915.pdf