Basic Research

Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model

天麻素通过抑制小胶质细胞介导的神经炎性反应保护急性高眼压模型视网膜神经节细胞

Jia-wei Wang, Yao-ming Liu, Xiao-fei Zhao, Xiu-lan Zhang, Han zhang

2017;10(10):1483-1489   DOI:10.18240/ijo.2017.10.01
 

【Recommended reason】This study elucidate the influence of gastrodin on the retinal ganglion cells (RGCs) survival in an acute ocular hypertension (AOH) rat model, and further investigated its possible mechanism. The finding demonstrates the potential application of gastrodin in the neuroprotective therapy of acute glaucoma and other retinal neurodegenerative diseases characterized by microglia activation and RGCs death.

【推荐理由】该研究阐述了天麻素对急性高眼压大鼠模型中视网膜神经节细胞存活率的影响，并进一步探讨了其可能存在的作用机制，同时文章也证实了天麻素在以小胶质细胞活化和视网膜神经节细胞凋亡为特征的急性青光眼及其它视网膜神经退行性疾病中神经保护治疗的潜在应用。http://www.ijo.cn/en_publish/2017/10/20171001.pdf

The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline

富氢盐水在改善MNU诱导的大鼠视网膜色素变性的作用

Wei-Ming Yan, Tao Chen, Xiao-Cheng Wang, Lin-Song Qi, Guan-Hua Zhao, Guo-Qing Yang, Yi-Fei Ma, Ye Tao, Lei Zhang, Zuo-Ming Zhang

2017;10(10):1495-1503  DOI:10.18240/ijo.2017.10.03
 

【Recommended reason】This paper investigates the effects of hydrogen-rich saline on microglia activation and Sirtuin type 1 (Sirt1) in rats with N-methyl-N-nitrosourea (MNU)-induced retinitis pigmentosa. Hydrogen-rich saline can effectively keep microglia activation induced by MNU to an appropriate extent, while upregulate Sirt1 in MNU-induced retinitis pigmentosa.

【推荐理由】该文探讨了富氢盐水对MNU诱导的大鼠视网膜色素变性小神经胶质细胞活性和Sirt1的影响。富氢盐水在适当地范围内可抑制MNU诱导的小神经胶质细胞的活性，也可上调视网膜中Sirt1水平。 
http://www.ijo.cn/en_publish/2017/10/20171003.pdf

Clinical Research

Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

应用OCT血管成像方法测量糖尿病视网膜病变不同阶段中央凹无血管区面积和旁中央凹血管密度

Rodolfo Mastropasqua, Lisa Toto, Alessandra Mastropasqua, Raffaella Aloia, Chiara De Nicola, Peter A Mattei, Guido Di Marzio, Marta Di Nicola, Luca Di Antonio
2017;10(10):1545-1551     DOI:10.18240/ijo.2017.10.11

This study investigates the foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and draws a conclusion that OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity. FAZ area and PRVD measurements using OCTA are highly reproducible.

文章通过OCT血管成像方法对糖尿病无视网膜病变患者及有视网膜病变患者的黄斑中央凹无血管区面积及旁中央凹血管密度进行了检测，结果发现随着视网膜病变的进展，中央凹无血管区面积逐渐增大，旁中央凹血管密度减少，并且两个参数具有高度的可重复性。
http://www.ijo.cn/en_publish/2017/10/20171011.pdf

Evaluation of refractive correction for standard automated perimetry in eyes wearing multifocal contact lenses

评价标准自动视野检查前进行多焦点角膜接触镜屈光矫正的作用

Kazunori Hirasawa, Hikaru Ito, Yukari Ohori, Yui Takano, Nobuyuki Shoji

2017;10(10):1559-1565   DOI:10.18240/ijo.2017.10.13
 

Optimal refractive correction is important in patients with glaucoma, as it is thought that decreasing sensitivity induced by inadequate refractive correction influences the estimate of visual field progression. The study evaluated the refractive correction required for standard automated perimetry testing (SAP) in eyes with multifocal contact lenses. The results indicate that, when the dome-shaped visual field test is administered in eyes with large pupils and wearing refractive multifocal contact lenses, distance correction without additional near correction is required.

最佳屈光矫正对于青光眼患者来说非常重要。事实上，屈光矫正不足引起的视觉敏感性下降会影响视野的评估。该研究评价了标准自动视野检查前进行多焦点角膜接触镜屈光矫正的作用。结果表明，在瞳孔较大且配戴多焦点角膜接触镜进行视野检查时，应进行远距离屈光矫正，无需进行近距离校正。

http://www.ijo.cn/en_publish/2017/10/20171013.pdf

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