Basic Research

Suppression of corneal neovascularization by curcumin via inhibition of Wnt/β-catenin pathway activation

姜黄素通过抑制Wnt/β-catenin信号通路的激活抑制角膜新生血管生成
Yong-Kang Zhang, Jing-Ming Li, Li Qin

2017,10(12):1791-1797   DOI：10.18240/ijo.2017.12.01

The authors described the effect of Wnt/β-catenin signaling in corneal neovasculrization and observed anti-angiogenic effect and inhibitory mechanism of curcumin in vitro and in vivo study. The results showed that curcumin is the chemical that has anti-angiogenic effect.

作者描述了Wnt/β-catenin信号通路在角膜新生血管形成中的作用以及姜黄素在体外和活体研究中的抗血管生成效应机制。该结果表明姜黄素具有抗血管生成作用。

http://www.ijo.cn/en_publish/2017/12/20171201.pdf
 

Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy

血管生成素样蛋白8与增生性糖尿病视网膜病变相关的临床和实验研究

Chang-Xia Dong, Cai-Ping Song, Chun-Ping Zhang, Mei Dong, Xiu-Rong Gong, He-Ying Gao, Hong Wang

2017,10(12):1819-1823  DOI：10.18240/ijo.2017.12.05
 

This study collected the sera and aqueous humor of 10 proliferative diabetic retinopathy (PDR) patients and 10 non-diabetic retinopathy (NDR) patients (idiopathic macular hole patients) and detected the expression of angiopoietin-like protein 8 (Angptl 8) by ELISA. The results indicated that the expression of Angptl 8 is increased in PDR, and the increased Angptl 8 can promote proliferation and increase proliferation-related factors.

该研究收集了10例增生性糖尿病视网膜病变患者和10例非糖尿病性视网膜病变(特发性黄斑裂孔)患者的血清和眼房水，并通过酶联免疫吸附法检测血管生成素样蛋白8 (Angptl 8) 的表达。结果表明，在增生性糖尿病视网膜病变患者中，Angptl 8的表达升高，而升高的Angptl 8可以促进增生，并提高增生相关因子的表达。

http://www.ijo.cn/en_publish/2017/12/20171205.pdf
 

Clinical Research

Clinical outcomes of a new diffractive multifocal intraocular lens

新型衍射多焦人工晶状体的临床效果

Baha Toygar, Ozge Yabas Kiziloglu, Okan Toygar, Ali Murat Hacimustafaoglu

2017,10(12):1844-1850   DOI：10.18240/ijo.2017.12.09

Optiflex MO/HF D012 (Moss Vision Inc. Ltd, London, UK) is a new generation multifocal IOL, which has a diffractive step design and an aspheric optic to minimize photic phenomena and to provide optimal visual outcomes without impairing contrast sensitivity. The Optiflex MO/HF-DO12 IOL was safely implanted and successfully restored distance, intermediate and near visual acuity.

Optiflex MO/HF D012是有阶梯衍射结构设计的新一代非球面多焦人工晶状体，非球面设计可减轻炫光症状，在不损害对比敏感度的情况下取得最佳的视觉效果。Optiflex MO/HF-DO12人工晶状体可以安全植入并成功修复不同距离的视力缺损.
http://www.ijo.cn/en_publish/2017/12/20171209.pdf

Optic nerve compression: the role of the lamina cribrosa and translaminar pressure

视神经压迫：筛板和贯穿筛板压力的作用

Mario R Romano, Gilda Cennamo, Maria Angelica Breve, Michela Piedepalumbo, Claudio Iovino, Nunzio Velotti, Giovanni Cennamo

2017,10(12):1883-1888  DOI：10.18240/ijo.2017.12.15

The authors investigated the morphology changes of lamina cribrosa (LC) and ganglion cell complex in patients affect by optic nerve compression secondary to Graves' ophthalmopathy (GO). They found that GO reduces cerebrospinal fluid and subarachnoid space (SAS) in the retrobulbar space due to the orbital congestion of superior ophthalmic vein and crowded orbital apex. The reduction of SAS induces the LC morphology changes with damage of ganglion cell complex and retinal nerve fiber layer.

作者研究了Graves眼病（GO）继发视神经压迫患者筛板(LC)和节细胞复合体的形态变化。发现GO患者球后间隙的脑脊液减少和蛛网膜下腔(SAS)缩小是由于眶内眼上静脉淤血和眶尖拥挤。SAS缩小导致LC形态改变伴随神经节细胞复合体和视网膜神经纤维层的损伤。
http://www.ijo.cn/en_publish/2017/12/20171215.pdf
 

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