Basic Research

Experimental circumferential canaloplasty with a new Schlemm canal microcatheter
新型微导管应用于全周Schlemm管成形术的实验研究

Mao-Song Xie, Yong-Zheng Zheng, Li-Bin Huang, Guo-Xing Xu

2018,11(1):1-5   DOI：10.18240/ijo.2018.01.01
【Recommended reason】

This study observed intraocular pressure (IOP) of rabbit glaucoma model before and after circumferential canaloplasty. The results showed that the IOP was lower in the treatment group than that in the model group 3, 7, 14 and 28d post-operation. Schlemm canal microcatheter could be used to perform circumferential canaloplasty in the rabbit glaucoma animal model. The differences among the groups indicates that circumferential canaloplasty is safe and effective in control of experimental glaucoma model in rabbits

该研究分别观察了全周Schlemm管成形术前以及术后兔青光眼模型的眼内压。结果显示，治疗组术后3、7、14、28天的眼内压均低于对照组，表明该微导管可用于兔青光眼模型的Schlemm管成形术，并且Schlemm管成形术对兔青光眼模型的控制安全有效。

http://www.ijo.cn/en_publish/2018/1/20180101.pdf

Clinical Research

Comparison of long-term results of trabeculectomy to treat pseudoexfoliative glaucoma and primary open angle glaucoma

Vuslat Pelitli Gürlü, Hande Güçlü, Altan Özal, Ömer Benian, Levent Alimgil

比较小梁切除术治疗剥脱综合征性青光眼和原发性开角型青光眼的长期疗效

 2018,11(1):66-70   DOI：10.18240/ijo.2018.01.12

【Recommended reason】
The study aimed to compare the long-term results of trabeculectomy in pseudoexfoliative (PEG) and primary open angle glaucoma (POAG) patients. The results indicated that there is no difference in the long-term success of trabeculectomy between PEG and POAG patients whose clinical characteristics are otherwise the same.

该研究旨在比较小梁切除术治疗剥脱综合征性青光眼和原发性开角型青光眼的长期疗效。结果表明，对于临床特征相同的PEG和POAG患者，小梁切除术的长期手术疗效相同。

http://www.ijo.cn/en_publish/2018/1/20180112.pdf

Intravitreal dexamethasone implants for diabetic macular edema

玻璃体腔内注射地塞米松植入剂治疗糖尿病黄斑水肿

Alicia Pareja-Ríos, Paloma Ruiz-de la Fuente-Rodríguez, Sergio Bonaque-González, Maribel López-Gálvez, Virginia Lozano-López, Pedro Romero-Aroca

2018,11(1):77-82   DOI：10.18240/ijo.2018.01.14

【Recommended reason】

The manuscript represent a large sample of patient, with 113 eyes, showed that intravitreal dexamethasone implant resulted in a significant improvement of BCVA, a reduction of central macular thickness and macular volume in patients with refractory diabetic macular edema. The technique proved safe and effective with repeated treatments during the 12mo follow-up period.

作者应用大样本（113眼）的研究，发现玻璃体内注射地塞米松植入剂可提高最佳矫正视力，并降低难治性糖尿病黄斑水肿患者黄斑中央凹厚度与体积。在12mo随访期间，多次注射安全有效。

http://www.ijo.cn/en_publish/2018/1/20180114.pdf

Review

A feasibility study of using biodegradable magnesium alloy in glaucoma drainage device
可生物降解镁合金在青光眼引流装置中应用的可行性研究

Xiang-Ji Li, Lin Xie, Fu-Sheng Pan,Yong Wang, Hong Liu, Yu-Rong Tang, Cindy ML Hutnik

2018,11(1):135-142   DOI：10.18240/ijo.2018.01.21

Abstract

Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure. Magnesium is an essential element for the human body and plays a critically important role for maintaining the functional and structural integrity of several tissues, including the eye. Due to several of its advantageous properties such as non-toxicity, biodegradability, and high biological compatibility, magnesium alloy has attracted great attention as a novel biomaterial. Biodegradable cardiovascular stents made of magnesium alloy have already been introduced into clinical practice and may be a very promising candidate for the development of a new generation of glaucoma drainage device.

青光眼的技术进步使传统的治疗模式受到挑战。以往的切口手术一直应用于进展期或药物、激光无法控制眼压的病例。最近，由于成像技术的进步，外科手术在治疗早期已经被认为是有益的。尽管如此，手术治疗的组织和伤口愈合的不可预测性仍会导致手术失败。镁是人体必需的元素，对维持包括眼睛在内的多种组织的功能和结构完整性起着至关重要的作用。镁合金具有无毒、可生物降解、生物相容性好等优点，作为一种新型生物材料受到了人们的广泛关注。镁合金可生物降解心血管支架已应用于临床，并有望成为新一代青光眼引流装置的发展方向。

http://www.ijo.cn/en_publish/2018/1/20180121.pdf