Basic Research

Role of vasoactive intestinal peptide in Aspergillus fumigatus-infected cornea

血管活性肠肽在烟曲霉感染角膜中的作用

Cui Li, Yuan-Yuan Liu, Gui-Qiu Zhao, Jing Lin, Cheng-Ye Che, Nan Jiang, Na Li, Jie Zhang, Kun He, Xu-Dong Peng
2018,11(2):183-188   DOI：10.18240/ijo.2018.02.01

This study tested the expression of vasoactive intestinal peptide (VIP) in C57BL/6 and BALB/c normal and Aspergillus fumigatus (A. fumigatus) infected corneas by polymerase chain reaction (PCR). The results showed that recombinant VIP alleviated A. fumigatus keratitis response of C57BL/6 mice, while VIP antagonist resulted in worsened disease response of BALB/c mice. Therefore, VIP played anti-inflammatory role in A. fumigatus keratitis.

该研究通过聚合酶链反应分别检测了C57BL/6和BALB/c型小鼠正常和烟曲霉感染角膜血管活性肠肽的表达。结果表明，重组血管活性肠肽缓解了C57BL/6小鼠的烟曲霉菌性角膜炎的炎性反应，而血管活性肠肽拮抗剂导致BALB/c小鼠的疾病反应恶化。因此，血管活性肠肽在烟曲霉菌性角膜炎中发挥抗炎作用。

http://www.ijo.cn/en_publish/2018/2/20180201.pdf

Clinical Research

Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea
改良溃疡清创术治疗角膜浅层真菌感染

Jun-Yi Wang, Dian-Qiang Wang, Xiao-Lin Qi, Jun Cheng, Li-Xin Xie

2018,11(2):223-229    DOI：10.18240/ijo.2018.02.07

This paper introduces an innovative technique: modified corneal ulcer debridement and evaluates the efficacy of the technique in superficial fungal keratitis unresponsive to medications. It includes the patients with fungal keratitis involving no more than 50% of the stromal depth and not responding to antifungal agents for 2wk. This debridement removed all visible corneal infiltrates under an operating microscope to obtain a clean stromal bed and smooth incised edges. This is a simple and effective method for this difficult disease, with improved visual acuity and no recurrence. Such an intervention in time can rapidly control fungal infection and largely shorten corneal ulcer healing time.

该文介绍了一种新的手术技术：改良角膜溃疡清创术，并评价了该技术对药物治疗无效的浅表真菌性角膜炎的疗效。研究纳入的真菌性角膜炎病例为病变不超过50%基质厚度，并且两周的抗真菌药物无效。这种清创术在手术显微镜下清除了所有可见的角膜浸润，获得了干净的基质床和光滑的切缘。这是一种治疗这种难治性疾病的简单而有效的方法，手术可提高视力并且无复发病例。这种及时干预能迅速控制真菌感染，大大缩短角膜溃疡愈合时间。

http://www.ijo.cn/en_publish/2018/2/20180207.pdf

Meta-analysis

Effects of lipid-lowering agents on diabetic retinopathy: a Meta-analysis and systematic review
降脂药对糖尿病视网膜病变影响的Meta分析及系统评价

Rui Shi, Lei Zhao, Feng Wang, Fen Liu, Zhuo Chen, Rong Li, Yang Liu, Rong Lin

2018,11(2):287-295    DOI：10.18240/ijo.2018.02.18

Diabetic Retinopathy (DR) remains a major source of irreversible vision loss in patients with diabetes. The role(s) of lipid-lowering agents in the development of DR remain controversial. Therefore, the authors performed this systematic review and Meta-analysis to clarify the role(s) of lipid-lowering reagents in DR development. They found that lipid-lowering agents could reduce the risk in the formation and progression of DR and potentially had protective effect on the development of diabetic macular edema. However, both types of lipid-lowering drugs had no protective effect on vision acuity and hard exudates. Intensive control of lipid with fibrates at the early stage of DR may offer a helpful strategy for delaying DR progression.

糖尿病视网膜病变（DR）是造成糖尿病患者视力永久丧失的主要原因之一。降脂药物对DR疾病进展的作用仍存在争议。因此，作者进行了系统性回顾及Meta分析，以阐明降脂药物在DR进程中的作用。研究发现降脂药物可以降低DR形成和加重的风险，并可能预防糖尿病黄斑水肿。然而，两种降脂药物在保护视力和预防硬性渗出方面没有作用。应用贝特类药物加强脂质控制可在DR早期延缓病情进展。

http://www.ijo.cn/en_publish/2018/2/20180218.pdf

Investigation

Gender differences in adolescent dry eye disease: a health problem in girls

青少年干眼病的性别差异: 女生的健康问题

Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi

2018,11(2):301-307    DOI：10.18240/ijo.2018.02.20

The study evaluated the signs and symptoms of dry eye disease (DED) in adolescents. The finding demonstrates adolescents’ symptoms of DED are similar to the found in adults, and the majority have short break up time-type DED. The prevalence and severity of DED in late adolescent girls was comparable with adults. It is meaning for adolescents with DED to get fully medical served.

该研究评估了青少年干眼病的体征和症状。结果表明患干眼病青少年的症状与成人相似，且大多数泪膜破裂时间短。青春期后期女生患干眼病的流行程度和严重程度与成人相当。这些结果对于患干眼病的青少年早期得到充分医疗服务是有指导意义的。

http://www.ijo.cn/en_publish/2018/2/20180220.pdf

Brief Report

Mechanism of delayed conduction of fellow eyes in patients with optic neuritis
视神经炎患者对侧眼传导延迟的机制研究

Daniah Alshowaeir, Con Yiannikas, Clare Fraser, Alexander Klistorner
2018,11(2):329-332   DOI：10.18240/ijo.2018.02.24

The authors tested the assumption that a shift in latency and changes of multi-focal visual evoked potential traces in fellow eyes of optic neuritis patients, and the results shown that preexisting demyelinating activity may be responsible to a significant degree for the multi-focal visual evoked potential latency delay in optic neuritis patients.

该文作者对视神经炎患者对侧眼的多焦点视觉诱发电位变化及潜伏期的改变的假设进行了验证，结果表明已经存在的脱髓鞘改变可能是视神经炎患者多焦视觉诱发电位潜伏期延迟的重要原因。

http://www.ijo.cn/en_publish/2018/2/20180224.pdf