Basic Research

Protective effects of a composition of Chinese herbs-Gurigumu-13 on retinal ganglion cell apoptosis in DBA/2J glaucoma mouse model
Gu-Ri-Gu-Mu通过抑制DBA/2J小鼠氧化应激和细胞内质网应激反应防止视网膜神经节细胞凋亡

Qiu-Li Zhang, Wei Wang, Yan Jiang, Tian-Zi Zhang, Zhan-Jun Lu, Ao Jiang

The study aimed to provide experimental basis for the further application of Gu-Ri-Gu-Mu in the treatment of glaucoma. The results provided strong evidence that Gu-Ri-Gu-Mu had obvious protective effects on retinal ganglion cells in DBA/2J mice, increased the number of retinal ganglion cells and axons via inhibiting oxidative stress and endoplasmic reticulum stress.

该研究旨在为Gu-Ri-Gu-Mu治疗青光眼进一步的应用提供实验依据。研究结果有力的证明通过抑制DBA/2J小鼠氧化应激和内质网应激，Gu-Ri-Gu-Mu对其视网膜神经节细胞有明显的保护作用，可增加视网膜神经节细胞和轴突的数量。

2018,11(3):363-368   DOI：10.18240/ijo.2018.03.03
 

http://www.ijo.cn/en_publish/2018/3/20180303.pdf

miR-211 regulates the antioxidant function of lens epithelial cells affected by age-related cataracts

miR-211对年龄相关性白内障晶状体上皮细胞抗氧化功能的研究

Bo Lu, Ian T. Christensen, Li-Wei Ma, Tao Yu, Ling-Feng Jiang, Chun-Xia Wang, Li Feng, Jin-Song Zhang, Qi-Chang Yan, Xin-Ling Wang

This study detected miR-211 expression in the anterior lens capsules of healthy people, the anterior lens capsules of patients with age-related cataracts, and human epithelial cell line (SRA01/04) cells exposed to oxidative stress. The result showed that miR-211 is upregulated in the anterior lens capsules of age-related cataract patients. miR-211 decreased the antioxidative stress capacity of lens epithelial cells by upregulating p53 and Bax, while inhibiting cell proliferation and repair. This finding suggests that miR-211 may play a key role in the development of age-related cataracts.

本研究检测了健康人、年龄相关性白内障患者的晶状体前囊膜以及人晶体上皮细胞系SRA01/04在氧化应激情况下miR-211的表达。结果显示，年龄相关性白内障患者的晶状体前囊膜miR-211表达增高。miR-211通过上调p53和Bax降低晶状体上皮细胞的抗氧化应激能力，抑制细胞增殖和修复。研究表明，miR-211可能在年龄相关性白内障的进展中起关键作用。
2018,11(3):349-353   DOI：10.18240/ijo.2018.03.01
 

http://www.ijo.cn/en_publish/2018/3/20180301.pdf

Clinical Research

Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency

低浓度透明质酸钠可短暂提高脂质缺乏性干眼患者的泪膜脂质层厚度

Yan Li, Xuan Sang, Liu Yang, Xiao-Ran Wang, Jia-Hui Liu, Xiong-Jun He, Ying Liu, Xiao-He Lu, Zhi-Chong Wang

This paper investigates the effects of different concentrations of artificial tears on lipid layer thickness (LLT) and blink rate (BR) in dry eye patients. A low concentration of artificial tears have a stronger effect than a high concentration of artificial tears on the increase in LLT. In comparison, sodium hyaluronate eye drops induce a transient and slight decrease in LLT of patients without lipid deficiency. A low concentration of artificial tears might be better for patients with lipid deficiency.

该文研究了不同浓度人造泪液对干眼患者脂质层厚度和眨眼频率的影响。相比于高浓度的人造泪液，低浓度的人造泪液对增加脂质层厚度有更强的作用。相比之下，透明质酸钠滴眼液对于非脂质缺乏性干眼症患者可引起短暂、轻微地脂质层厚度减少。低浓度人造泪液更能有效治疗脂质缺乏性干眼症。
2018,11(3):389-394  DOI：10.18240/ijo.2018.03.07
 

http://www.ijo.cn/en_publish/2018/3/20180307.pdf

Cap morphology after small-incision lenticule extraction and its effects on intraocular scattering

SMILE术后角膜帽形态及其对眼内光散射的影响

Dan Fu, Lin Wang, Xing-Tao Zhou, Zhi-Qiang Yu

The study utilized a double-pass system to objectively assess optical quality, and FD-OCT to perform non-contact measurement of corneal caps after SMILE. And aimed to find whether a relationship exists between cap morphology and intraocular scattering. The corneal cap tends to be more accurate and regular with time lapse. Better cap morphology tends to contribute less intraocular scattering in the eyes undergoing SMILE.

该研究利用双通道系统来客观评估人眼光学质量，并利用FD-OCT对SMILE术后角膜帽形态进行非接触测量。其主要目的是研究角膜帽形态与眼内散射光是否存在相关性。随着时间的推移，角膜帽会变得更加精确和规则，更好的帽状形态有助于减少眼内光散射。
2018,11(3):456-461  DOI：10.18240/ijo.2018.03.16
 

http://www.ijo.cn/en_publish/2018/3/20180316.pdf

Meta-Analysis

Comparison of visual outcomes with implantation of trifocal versus bifocal intraocular lens after phacoemulsification: a Meta-analysis

白内障超声乳化植入三焦或双焦人工晶体术后视力比较的Meta分析

Juan-Juan Yang, Qiu-Ping Liu, Jing-Ming Li, Li Qin

The authors compared the visual outcomes after implantation of trifocal IOL and bifocal/multifocal IOL by a systemic review. All the evidence were from randomized controlled clinical trials. All results indicate that trifocal IOL and bifocal IOL had similar levels of monocular distance and near visual acuities. The study would provide the preferred evidence for ophthalmologists and could also benefit patients with higher requirement of visual outcomes after cataract surgeries.

作者系统回顾比较了植入三焦点人工晶体与植入双焦点或多焦点人工晶体的术后视力。所有资料均来源于随机对照临床试验，结果表明三焦和双焦人工晶体具有相似的单眼远近视力。该研究可为眼科专家提供优
先参考依据，并有益于对白内障术后视力要求较高的患者。
2018,11(3):484-492  DOI：10.18240/ijo.2018.03.20
 

http://www.ijo.cn/en_publish/2018/3/20180320.pdf