Basic Research

Evaluation of a rat meibomian gland dysfunction model induced by closure of meibomian gland orifices

大鼠睑板腺口封闭致睑板腺功能障碍模型的评价

Zi-Yi Dong, Ming Ying, Jie Zheng, Lan-Jun Hu, Jiang-Yan Xie, Yi Ma

The aim of this article is to find a stable, inexpensive, and reliable method to produce a rat meibomian gland dysfunction (MGD) model. The technician inserted slim guidewires into the meibomian gland orifices of rats and fulgurized every guidewire to destroy part of the meibomian gland. Then observed the morphological changes in the eyelid margin, and compared the data of tear breakup time (TBUT), Schirmer I test, and the corneal fluorescence staining scores at different times (1, 2, 4, and 6wk) as well as pathological changes of the cornea, conjunctiva and meibomian gland. The results showed that the MGD rat model, produced via electrocauterization of meibomian gland orifices, matched clinical manifestations and cytokine levels. This research provides a new method of achieving an MGD animal model.

该文旨在寻找一种稳定、廉价、可靠的方法来建立大鼠睑板腺功能障碍模型。实验人员将纤细的导丝插入大鼠的睑板腺孔中，并对每根导丝进行电灼，破坏部分睑板腺。观察睑缘的形态变化，并比较1、2、4、6周泪膜破裂时间、Schirmer I试验和角膜荧光染色评分，以及角膜、结膜、睑板腺的病理变化。结果表明通过对睑板腺口的电灼造成睑板腺功能障碍大鼠模型符合临床表现和细胞因子水平。此项研究为睑板腺功能障碍动物模型提供了一种新的方法。

http://www.ijo.cn/en_publish/2018/7/20180701.pdf

Clinical Research

Effect of long-term topical latanoprost medication on conjunctival thickness in patients with glaucoma

长期应用拉坦前列腺素对青光眼患者结膜厚度的影响

Qing-Song Li, Fang-Fang Bao, Zhen-Yong Zhang, Kai Ma

This is the first report regarding the effect of latanoprost on conjunctival and conjunctival epithelium thickness in glaucoma patients. This study presented a significant decrease in conjunctival thickness in glaucoma patients treated with long-term topical latanoprost. Its potential effect on the outcome of filtration surgery should be considered.

该研究首次报道了拉坦前列腺素对青光眼患者的结膜和结膜上皮厚度的影响。研究显示，长期局部使用拉坦前列腺素治疗的青光眼患者结膜厚度显著降低，应考虑其对过滤手术结果的潜在影响。

http://www.ijo.cn/en_publish/2018/7/20180714.pdf

Clinical Research

Repeatability of in-vitro optical quality measurements of intraocular lenses with a deflectometry technique effect of the toricity

复曲面偏折技术对体外人工晶体光学质量测量的可重复性研究

Teresa Ferrer-Blasco, Alberto Domínguez-Vicent, Santiago García-Lázaro, María Amparo Díez-Ajenjo, José F. Alfonso, José J. Esteve-Taboada

The authors evaluated the repeatability of an optical device (NIMO TR1504) for measuring the Zernike coefficients of toric intraocular lenses and checked whether its toricity has any impact in its repeatability. Concretely, the repeatability was assessed following the new standards based on within subject standard deviation and repeatability limit. Finally, the results obtained in the present study pointed out that this system is robust and could be used to measure the in-vitro optical quality of either toric or non-toric IOLs.

作者评估了NIMO TR1504光学仪器测量复曲面人工晶体Zernike系数的可重复性以及复曲面对重复性的影响。具体方法是基于受试者内部标准差和重复性限的新标准评估其重复性。结果表明，该系统很稳定，可以用于测量体外复曲面或非复曲面人工晶体的光学质量。

http://www.ijo.cn/en_publish/2018/7/20180711.pdf

Clinical Research

Macular integrity assessment to determine the association between macular microstructure and functional parameters in patients with diabetic macular edema

黄斑完整性评估对糖尿病黄斑水肿患者黄斑微结构与功能参数相关性的影响

Jian-Wei Wang, Chuan-Hong Jie, Yong-Jian Tao, Ning Meng, Yuan-Chun Hu, Zheng-Zheng Wu, Wen-Jing Cai, Xi-Mei Gong

The study aimed to evaluate macular morphological features and functional parameters by using spectral-domain optical coherence tomography and macular integrity assessment in patients with diabetic macular edema. The results revealed functional (best corrected visual acuity and visual field) and morphological parameters (retinal thickness) were significantly associated with an intact IS/OS.

该研究应用频域光学相干断层扫描和黄斑完整性评估糖尿病黄斑水肿患者的黄斑形态学特征和功能参数。结果显示功能参数(最佳矫正视力和视野)和形态学参数(视网膜厚度)与IS/OS的完整性显著相关。

http://www.ijo.cn/en_publish/2018/7/20180718.pdf