Featured Articles in International Journal of Ophthalmology Vol.11 No.9, 2018

Basic Research

In vivo biodistribution of topical low molecular weight heparin-taurocholate in a neovascularized mouse cornea


Chan Hee Moon, Ji Yun Lee, Eun Soon Kim, Jin Hyoung Park, Sang-Yeob Kim, Jae Yong Kim, Hungwon Tchah


The authors investigate the ocular biodistribution of topically administered taurocholic acid conjugated low-molecular weight heparin (LHT7) using an in vivo optical imaging system in neovascularized mice cornea. Topically administered LHT7 showed a high biodistribution in corneal neovascularization areas for 4h after instillation. The authors concluded that topical LHT7 should be instilled at least every 4 to 6 h to maintain a high distributional level, and in vivo optical imaging can be a useful tool for evaluating ocular biodistribution.




Clinical Research

The inflammation influence on corneal surface after frontalis suspension surgery


Kang Li, Xin-Chun Zhang, Xian-Xian Cai, Ya-Dan Quan, Rong Lu


This study investigated the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines. Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage. According to the results, frontalis muscle flap suspension surgery is a good choice for blepharoptosis patients with poor levator function because of the effectiveness and stability.






Cell death and survival following manual and femtosecond laser-assisted capsulotomy in age-related cataract


Andrea Krisztina Sükösd, Judit Rapp, Diána Feller, György Sétáló Jr., Beáta Gáspár, Judit E. Pongrácz, Hajnalka Ábrahám, Zsolt Biró


The study aimed to study molecular and morphological changes in lens epithelial cells following femtosecond laser-assisted and manually performed continuous curvilinear capsulotomy (CCC) in order to get information about these methods regarding their potential role in the induction of development of secondary cataract. The results indicated that cell survival and proliferation were for the most part insignificant following manual continuous curvilinear capsulotomy and femtosecond laser-assisted capsulotomy, therefore both methods appear to be fully suitable for the removal of the anterior lens capsules in age-related cataract.




Clinical Research

Lipid layer thickness and tear meniscus height measurements for the differential diagnosis of evaporative dry eye subtypes


Xuan Sang, Yan Li, Liu Yang, Jia-Hui Liu, Xiao-Ran Wang, Chao-Yang Li, Ying Liu, Chen-Jie Wang, Xiong-Jun He, Shou-Bi Wang, Zhi-Chong Wang


This study explored a new diagnostic index for differentiating the evaporative dry eye (EDE) subtypes by classifying EDE into obstructive meibomian gland dysfunction (MGD) EDE and non-obstructive MDG EDE and further to compared and analyzed their clinical characteristics. It concludes that using a combination of lipid layer thickness (LLT) and tear meniscus height measurements (TMH) measurements could help to differentiate these two EDE subtypes, which may result in the availability of more precise treatments for EDE patients in clinical practice.




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