Basic Research

In vivo biodistribution of topical low molecular weight heparin-taurocholate in a neovascularized mouse cornea

局部低分子肝素-牛磺胆酸在小鼠角膜新生血管中的生物分布

Chan Hee Moon, Ji Yun Lee, Eun Soon Kim, Jin Hyoung Park, Sang-Yeob Kim, Jae Yong Kim, Hungwon Tchah

The authors investigate the ocular biodistribution of topically administered taurocholic acid conjugated low-molecular weight heparin (LHT7) using an in vivo optical imaging system in neovascularized mice cornea. Topically administered LHT7 showed a high biodistribution in corneal neovascularization areas for 4h after instillation. The authors concluded that topical LHT7 should be instilled at least every 4 to 6 h to maintain a high distributional level, and in vivo optical imaging can be a useful tool for evaluating ocular biodistribution.

作者利用活体动物体内光学成像系统，研究了局部应用牛磺胆酸偶联低分子肝素(LHT7)在小鼠角膜新生血管中的生物分布。局部LHT7给药4小时后在角膜新生血管区呈现高生物分布。作者得出结论，局部LHT7应该至少每4-6小时给药一次，以保持较高的分布水平，且体内光学成像可以作为评估眼生物分布的有效方式。

http://www.ijo.cn/en_publish/2018/9/20180901.pdf

Clinical Research

The inflammation influence on corneal surface after frontalis suspension surgery

额肌瓣悬吊术后角膜表面的炎性反应

Kang Li, Xin-Chun Zhang, Xian-Xian Cai, Ya-Dan Quan, Rong Lu

This study investigated the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines. Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage. According to the results, frontalis muscle flap suspension surgery is a good choice for blepharoptosis patients with poor levator function because of the effectiveness and stability.

该研究通过分析额肌瓣悬吊术后的临床特点及炎性细胞因子，探讨该手术对眼表炎性反应的影响。额肌瓣悬吊术后早期会出现眼睑闭合不全，数月后缓解。术后早期炎症细胞因子水平的升高可能参与术后早期角膜上皮缺损的发生。额肌瓣悬吊术因其良好的有效性和稳定性，是上睑下垂提肌功能不佳患者的理想选择。

http://www.ijo.cn/en_publish/2018/9/20180910.pdf

Cell death and survival following manual and femtosecond laser-assisted capsulotomy in age-related cataract

年龄相关性白内障手法或飞秒激光辅助撕囊术后细胞的凋亡和存活情况

Andrea Krisztina Sükösd, Judit Rapp, Diána Feller, György Sétáló Jr., Beáta Gáspár, Judit E. Pongrácz, Hajnalka Ábrahám, Zsolt Biró

The study aimed to study molecular and morphological changes in lens epithelial cells following femtosecond laser-assisted and manually performed continuous curvilinear capsulotomy (CCC) in order to get information about these methods regarding their potential role in the induction of development of secondary cataract. The results indicated that cell survival and proliferation were for the most part insignificant following manual continuous curvilinear capsulotomy and femtosecond laser-assisted capsulotomy, therefore both methods appear to be fully suitable for the removal of the anterior lens capsules in age-related cataract.

该研究旨在研究飞秒激光辅助或手法行连续环形撕囊术(CCC)术后晶状体上皮细胞的分子和形态学变化，以了解这些方法在诱导继发性白内障发展中的潜在作用。结果显示手法和飞秒激光辅助撕囊对于细胞的生存和增殖没有显著影响，因此这两种方法都适合于年龄相关性白内障的晶状体前囊膜撕除。

http://www.ijo.cn/en_publish/2018/9/20180902.pdf

Clinical Research

Lipid layer thickness and tear meniscus height measurements for the differential diagnosis of evaporative dry eye subtypes

测量脂质层厚度和泪河高度鉴别诊断蒸发过强型干眼症

Xuan Sang, Yan Li, Liu Yang, Jia-Hui Liu, Xiao-Ran Wang, Chao-Yang Li, Ying Liu, Chen-Jie Wang, Xiong-Jun He, Shou-Bi Wang, Zhi-Chong Wang

This study explored a new diagnostic index for differentiating the evaporative dry eye (EDE) subtypes by classifying EDE into obstructive meibomian gland dysfunction (MGD) EDE and non-obstructive MDG EDE and further to compared and analyzed their clinical characteristics. It concludes that using a combination of lipid layer thickness (LLT) and tear meniscus height measurements (TMH) measurements could help to differentiate these two EDE subtypes, which may result in the availability of more precise treatments for EDE patients in clinical practice.

该文旨在运用新方法来鉴别诊断蒸发过强型干眼症的类型，作者将其分为阻塞性睑板腺功能障碍导致的干眼症和非阻塞性睑板腺功能障碍导致的干眼症并进一步对比分析各自的临床数据特征。最终研究结果表明联合测量脂质层厚度和泪河高度可以用来区分蒸发过强型干眼症的类型，进而能够更准确对干眼病患者进行临床指导。

http://www.ijo.cn/en_publish/2018/9/20180911.pdf