Highlighted Articles in Int J Ophthalmol Vol.11 No.10 2018

 

Clinical Research

The diluted atropine for inhibition of myopia progression in Korean children

低浓度阿托品抑制韩国青少年近视进展

Ji -Sun Moon, Sun Young Shin

This study evaluated the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. The results of our study showed that diluted atropine significantly controlled myopia in Korean children, and only a family history of high myopia was a risk factor for rapid myopia progression.

该文研究了三种不同低浓度阿托品分别用于抑制韩国青少年近视进展的有效性和安全性并对影响近视进展的高危因素进行了评估。其结果表明低浓度阿托品能够有效抑制韩国青少年近视进展,高度近视家族史是影响近视进展的高危因素。

http://www.ijo.cn/en_publish/2018/10/20181013.pdf



Basic Research

Alterations in the polysialylated neural cell adhesion molecule and retinal ganglion cell density in mice with diabetic retinopathy

糖尿病视网膜病变小鼠唾液酸神经细胞粘附分子和视网膜神经节细胞密度的改变

Natalia Lobanovskaya, Monika Jürgenson, Anu Aonurm-Helm, Alexander Zharkovsky

 

This study investigated the impact of polysialylated neural cell adhesion molecule (PSA-NCAM) on the survival of retinal ganglion cells (RGCs) in the experimentally induced diabetes in mice. The findings demonstrated that a decrease in PSA-NCAM levels in the NFL and GCL is associated with lower density of RGCs in diabetic retinas. A large increase in MMP-9 levels in NFL and GCL cause PSA-NCAM cleavage in the inner part of the retina. The causal relationship between PSA-NCAM and RGC survival, however, remains unclear. Currently the studies aiming at elucidation the roles of MMPs in the shedding of PSA-NCAM and the mechanisms by which PSA-NCAM regulates RGC survival are in progress in our laboratory.

该研究探讨了唾液酸神经细胞粘附分子对实验诱导糖尿病小鼠视网膜神经节细胞存活的影响。研究表明,视网膜神经纤维层和神经节细胞层中唾液酸神经细胞粘附分子水平的降低与糖尿病视网膜中的神经节细胞密度降低有关。神经纤维层和神经节细胞层中基质金属蛋白酶9的大幅增加会导致视网膜内层唾液酸神经细胞粘附分子的裂解。然而,唾液酸神经细胞粘附分子与视网膜神经节细胞存活之间的关系尚不清楚。该研究组将进一步阐明基质金属蛋白酶在唾液酸神经细胞粘附分子脱落过程中的作用以及唾液酸神经细胞粘附分子调控视网膜神经节细胞存活的机制。

http://www.ijo.cn/en_publish/2018/10/20181006.pdf

 

Basic Research

Protection of tight junction between RPE cells with tissue factor targeting peptide

组织因子靶向肽对视网膜色素上皮细胞紧密连接的保护作用

Xiu-Lan Zou, Guan-Feng Wang, Dan-Dan Li, Jing-Xia Chen, Chun-Li Zhang, Yong-Zhen Yu, Wen-Jie Zhou, Yu-Ping Zou, Ben-Qiang Rao

 

Tissue factor (TF) was one of the key mediators in the pathogenesis of choroidal neovascularization (CNV). The authors proved tissue factor targeting peptide (TF-TP) may be a potential protective agent against the formation of CNV, possibly through downregulating TF and enhancing the expression of ZO-1 in LPS-stimulated ARPE-19 cell to maintain the proper functions of blood-retinal barrier.

组织因子(TF)是脉络膜新生血管(CNV)发病的关键介质之一。组织因子靶向肽(TF-TP)可通过下调TF和增强ZO-1LPS诱导的ARPE-19细胞中的表达来维持血-视网膜屏障的正常功能,从而成为CNV形成的潜在保护剂。

http://www.ijo.cn/en_publish/2018/10/20181004.pdf

 

 

 

Clinical Research

Laser-assisted dacryocystorhinostomy in nasolacrimal duct obstruction: 5-year follow-up

激光辅助鼻腔泪囊吻合术治疗鼻泪管阻塞的5年随访研究

Mustafa , Anar Alizada, Güliz Fatma , Orhan Kemal Kahveci, Osman Bakan  

 

The study aimed to evaluate the long-term sucess rate of laser-assisted dacrycystorhinostomy (L-DCR) in patients with nasolacrimal duct obstruction. The results indicated that transcanalicular L-DCR is a reliable and fast procedure in the treatment of nasolacrimal duct obstruction. It can be alternative to external DCR which is accepted as the gold standard currently.

该研究旨在评估激光辅助鼻腔泪囊吻合术在鼻泪管阻塞患者中的长期疗效。结果表明,激光辅助鼻腔泪囊吻合术是治疗鼻泪管阻塞的可靠且快速的方法之一。它可作为目前被公认为黄金标准的外路鼻腔泪囊吻合术的替代手术。

http://www.ijo.cn/en_publish/2018/10/20181007.pdf

 


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