Highlighted Articles in Int J Ophthalmol Vol.11 No.10 2018


Clinical Research

The diluted atropine for inhibition of myopia progression in Korean children


Ji -Sun Moon, Sun Young Shin

This study evaluated the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. The results of our study showed that diluted atropine significantly controlled myopia in Korean children, and only a family history of high myopia was a risk factor for rapid myopia progression.



Basic Research

Alterations in the polysialylated neural cell adhesion molecule and retinal ganglion cell density in mice with diabetic retinopathy


Natalia Lobanovskaya, Monika Jürgenson, Anu Aonurm-Helm, Alexander Zharkovsky


This study investigated the impact of polysialylated neural cell adhesion molecule (PSA-NCAM) on the survival of retinal ganglion cells (RGCs) in the experimentally induced diabetes in mice. The findings demonstrated that a decrease in PSA-NCAM levels in the NFL and GCL is associated with lower density of RGCs in diabetic retinas. A large increase in MMP-9 levels in NFL and GCL cause PSA-NCAM cleavage in the inner part of the retina. The causal relationship between PSA-NCAM and RGC survival, however, remains unclear. Currently the studies aiming at elucidation the roles of MMPs in the shedding of PSA-NCAM and the mechanisms by which PSA-NCAM regulates RGC survival are in progress in our laboratory.




Basic Research

Protection of tight junction between RPE cells with tissue factor targeting peptide


Xiu-Lan Zou, Guan-Feng Wang, Dan-Dan Li, Jing-Xia Chen, Chun-Li Zhang, Yong-Zhen Yu, Wen-Jie Zhou, Yu-Ping Zou, Ben-Qiang Rao


Tissue factor (TF) was one of the key mediators in the pathogenesis of choroidal neovascularization (CNV). The authors proved tissue factor targeting peptide (TF-TP) may be a potential protective agent against the formation of CNV, possibly through downregulating TF and enhancing the expression of ZO-1 in LPS-stimulated ARPE-19 cell to maintain the proper functions of blood-retinal barrier.






Clinical Research

Laser-assisted dacryocystorhinostomy in nasolacrimal duct obstruction: 5-year follow-up


Mustafa , Anar Alizada, Güliz Fatma , Orhan Kemal Kahveci, Osman Bakan  


The study aimed to evaluate the long-term sucess rate of laser-assisted dacrycystorhinostomy (L-DCR) in patients with nasolacrimal duct obstruction. The results indicated that transcanalicular L-DCR is a reliable and fast procedure in the treatment of nasolacrimal duct obstruction. It can be alternative to external DCR which is accepted as the gold standard currently.




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