Featured Articles in International Journal of Ophthalmology Vol.11 No.11, 2018

Basic Research

Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs


Yuan Tao, Xiao-Li Li, Li-Yuan Sun, Yu-Hua Wei, Xiao-Ting Yu, Hong Wang

The authors aimed to investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor (mAChRs) M1 in the eyes of guinea pigs. Thirty guinea pigs (15-20 days old) were randomly divided into three groups. Animals in group I were raised in a completely closed carton with green flickering light illumination. Those in group II were kept in the open top closed carton under normal natural light. Guinea pigs were raised in a sight-widen cage under normal natural light in group III. Refraction was found to be significantly reduced among the three groups and axial length was significantly longer after over 8 weeks' experiments; However, there was no M1 receptor expression in choroid both in 3 groups. Myopia can be induced by 8 weeks’ green flickering light exposure. M1 receptor may be involved causally or protectively in myopia development.




Basic Research

Increased succinate receptor GPR91 involved in the pathogenesis of Mooren’s ulcer


Lin Li, Yan-Ling Dong, Ting Liu, Dan Luo, Chao Wei, Wei-Yun Shi

The study aimed to investigate the expression of succinate receptor GPR91 and its pathogenic roles in Mooren’s ulcer (MU). The authors found that the elevated expression of succinate receptor GPR91 in the MU samples. GPR91 signaling, depending on NF-κB activity, triggered the production of IL-1β, NLRP3, VEGF-A and MMP-13. These data suggested that GPR91 was probably involved in the pathomechanism of MU through its pro-inflammatory effect. This is the first study to provide evidence of a link between metabolism and the pathogenesis of MU, thereby broadening therapeutic targets for MU patients.





Clinical Research


Comparison of persistent submacular fluid in different preoperative macular status after vitrectomy for rhegmatogenous retinal detachment


Jian-Bo Mao, Jing-Jing Lin, Xue-Ting Yu, Dan Cheng, Yi-Qi Chen, Ji-Wei Tao, Han-Fei Wu, Lu Jiang, Yun Zhang, Li-Jun Shen

This study compare the incidence of persistent submacular fluid (SMF) and visual outcome after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) in different preoperative macular status according to optical coherence tomography (OCT). The result showed persistent SMF after PPV for retinal detachment was associated with preoperative macular status. Macula-uninvolving RRD showed no persistent SMF after PPV. Macular partly detached RRD had a higher incidence of SMF than macula totally detached RRD after PPV. The persistence of SMF may be responsible for the delayed visual recovery, whereas there were no significant differences in the final visual acuity.





Clinical Research


Clinical features of posterior microphthalmic and nanophthalmic eyes


Jing-Jing Liu, Yi-Ye Chen, Xiang Zhang, Pei-Quan Zhao

This study explored various features and clinical management of posterior microphthalmos and nanophthalmos to better understand and differentiate these rare conditions and their prognosis. The mechanisms of papillomacular folds formation was studied using optical coherence tomography. The results show that complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with nanophthalmos but not with posterior microphthalmos. The authors proposed that papillomacular folds and flattened macula in posterior microphthalmos and nanophthalmos may also develop as a result of a poorly differentiated macula because the presence of inner retinal layers in this area.





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