Highlighted Articles in Int J Ophthalmol Vol.11 No.12 2018


Basic Research


Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes


He-Nan Liu, Xun Li, Na Wu, Meng-Meng Tong, Shuo Chen, Shan-Shan Zhu, Wei Qian, Xiao-Long Chen

To validate the hypothesis based on previous studies, a cross-sectional study was conducted to identify whether serum miR-221 as a novel biomarker with high sensitivity and specificity for genetic diagnosis and biologic therapy in patients with diabetic retinopathy according to the epigenetic methodology. The results showed serum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D.




Clinical Research


Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery


Marcella Nebbios, Maria Luisa Livani, Valentina Santamaria, Aloisa Librando, Massimiliano Sepe

The study aimed to evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery. The results indicated that intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation.







Comparison of bilateral/unilateral lateral rectus recession and unilateral recession-resection for intermittent exotropia: a Meta-analysis


De-Sheng Song, Zhi-Jun Chen, Jing Qian

The basic type intermittent exotropia appears to be the most common of the subtypes and bilateral lateral rectus recession (BLR) and unilateral lateral rectus recession (ULR) combined with a medial rectus resection in the same eye (R&R) are the two most common surgical treatment approach. But there is a great deal of disagreement about which surgery is best. This is the first Meta-analysis comparing two kinds of surgeries. As regard to the effect of BLR and R&R, R&R shows an advantage over BLR at short term. But, BLR is more effective in the long term for the basic type intermittent exotropia in children. R&R surgery should be a better choice for the treatment of small-angle intermittent exotropia of ≤20 PD than ULR. However, both of ULR and R&R are recommended for moderate-angle intermittent exotropia from 20 PD to 25 PD.







Research progress about the effect and prevention of blue light on eyes


Zhi-Chun Zhao, Ying Zhou, Gang Tan, Juan Li

In recent years, people have become increasingly attentive to light pollution influences on their eyes. This study evaluated the effect of blue light on eyes and summarized the research on eye injury and its physical prevention and medical treatment. A certain extent blue light can promote human eye refractive development and regulate circadian rhythm, but blue light can also produce different degree of damage to corneal, crystal lens and retina. Therefore, it is necessary to take appropriate protective measures when using blue light-related products, especially at night.





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