Highlighted Articles in Int J Ophthalmol Vol.11 No.12 2018

 

Basic Research

 

Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes

血清microRNA-221作为2型糖尿病患者糖尿病视网膜病变的生物标志物

He-Nan Liu, Xun Li, Na Wu, Meng-Meng Tong, Shuo Chen, Shan-Shan Zhu, Wei Qian, Xiao-Long Chen

To validate the hypothesis based on previous studies, a cross-sectional study was conducted to identify whether serum miR-221 as a novel biomarker with high sensitivity and specificity for genetic diagnosis and biologic therapy in patients with diabetic retinopathy according to the epigenetic methodology. The results showed serum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D.

为了验证以往研究的假设,该研究根据表观遗传学方法,通过进行横断面研究来辨别血清microRNA-221是否作为具有高灵敏度和特异性的新型生物标志物,用于糖尿病视网膜病变患者的遗传诊断和生物治疗。结果显示,血清microRNA-221作为一种潜在的生物标志物,不仅与2型糖尿病患者视网膜病变的发生有关,而且与视网膜病变的发展有关。

 

http://www.ijo.cn/en_publish/2018/12/20181202.pdf



Clinical Research

 

Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery

前房内利多卡因辅助传统表面麻醉减轻白内障手术疼痛

Marcella Nebbios, Maria Luisa Livani, Valentina Santamaria, Aloisa Librando, Massimiliano Sepe

The study aimed to evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery. The results indicated that intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation.

该研究旨在研究前房内利多卡因辅助外用麻醉滴剂在白内障手术中的安全性、有效性和患者依从性。结果显示前房内注射利多卡因是一种简单、安全的方法,可以增加白内障手术过程中的镇痛效果,消除患者的不适,提高操作过程中患者的配合。

http://www.ijo.cn/en_publish/2018/12/20181209.pdf

 

 

Meta-Analysis

 

Comparison of bilateral/unilateral lateral rectus recession and unilateral recession-resection for intermittent exotropia: a Meta-analysis

间歇性外斜视双/单眼外直肌后徙术与单眼一退一截的比较

De-Sheng Song, Zhi-Jun Chen, Jing Qian

The basic type intermittent exotropia appears to be the most common of the subtypes and bilateral lateral rectus recession (BLR) and unilateral lateral rectus recession (ULR) combined with a medial rectus resection in the same eye (R&R) are the two most common surgical treatment approach. But there is a great deal of disagreement about which surgery is best. This is the first Meta-analysis comparing two kinds of surgeries. As regard to the effect of BLR and R&R, R&R shows an advantage over BLR at short term. But, BLR is more effective in the long term for the basic type intermittent exotropia in children. R&R surgery should be a better choice for the treatment of small-angle intermittent exotropia of ≤20 PD than ULR. However, both of ULR and R&R are recommended for moderate-angle intermittent exotropia from 20 PD to 25 PD.

间歇性外斜视是最常见的外斜类型。双侧外直肌后徙(BLR)和单侧外直肌后徙(ULR)联合眼内直肌截除术(R&R)是两种最常见的手术治疗方法。但是对于哪种手术更好还是存在很大分歧。该Meta分析第一次对两种手术进行了比较。在BLRR&R疗效方面,R&R在短期内表现优于BLR。但BLR对儿童间歇性外斜视的长期疗效更为显著。对于≤20PD的小角度间歇性外斜视,R&R优于ULR。对于从20PD25PD的中度间歇性外斜视,ULRR&R两种方法均适用。

http://www.ijo.cn/en_publish/2018/12/20181218.pdf

 

 

Review

 

Research progress about the effect and prevention of blue light on eyes

蓝光对眼睛的影响及其预防的研究进展

Zhi-Chun Zhao, Ying Zhou, Gang Tan, Juan Li

In recent years, people have become increasingly attentive to light pollution influences on their eyes. This study evaluated the effect of blue light on eyes and summarized the research on eye injury and its physical prevention and medical treatment. A certain extent blue light can promote human eye refractive development and regulate circadian rhythm, but blue light can also produce different degree of damage to corneal, crystal lens and retina. Therefore, it is necessary to take appropriate protective measures when using blue light-related products, especially at night.

近年来,人们越来越重视光污染对眼睛的影响。该文旨在研究蓝光对眼睛的影响并对其造成的眼损伤及物理预防措施和治疗方法进行了总结。一定程度内的蓝光能够促进眼屈光发育,调节生理节律,但是蓝光对角膜,晶状体和视网膜也会造成了不同程度的损伤。因此,在使用蓝光相关产品的时候,尤其是晚上,有必要采取相应的保护措施。

http://www.ijo.cn/en_publish/2018/12/20181220.pdf

 

 

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