Clinical Research

Fluorescein angiography of retinal vascular involution after intravitreal injection of ranibizumab for retinopathy of prematurity

玻璃体腔注射雷珠单抗治疗早产儿视网膜病变网膜血管退化的荧光血管造影

Yong Cheng, Tie-Gang Liu, Wei-Yi Li, Ming-Wei Zhao, Jian-Hong Liang

In the last years, anti-vascular endothelial growth factor (VEGF) treatment has been shown to be effective in treating retinopathy of prematurity (ROP). However, in a recent study, compared with laser-treated eyes, anti-VEGF treated eyes had significant residual vascular and macular abnormalities. Moreover, abnormal vascular patterns and large peripheral avascular areas may occur after anti-VEGF treatment for ROP. Although intravitreal ranibizumab can be very effective in ROP, we should remain cautious as infants may remain avascular peripheral retinas and abnormal vessel. Fluorescein angiography allows accurate visualization of vessel abnormalities in eyes with ROP, which will be helpful to affect assessment of disease activity and therapeutic effect.

近年来，抗血管内皮生长因子(VEGF)治疗早产儿视网膜病变(ROP)已证实有效。然而，在最近的一项研究中，与激光治疗相比，抗VEGF治疗明显存在血管残留和黄斑异常。此外，抗VEGF治疗ROP后，可能出现异常血管和较大的周边视网膜无灌注区。尽管玻璃体腔注射雷珠单抗在ROP中非常有效，但仍应保持谨慎，因为婴儿可能仍存在视网膜周边缺血和异常血管。荧光素血管造影术能准确显示ROP眼血管异常，有助于评估疾病活动度和治疗效果。

http://www.ijo.cn/en_publish/2019/1/20190112.pdf

Investigation

Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion

利用深度学习技术和超广角眼底镜来诊断视网膜分支静脉阻塞

Daisuke Nagasato, Hitoshi Tabuchi, Hideharu Ohsugi, Hiroki Masumoto, Hiroki Enno, Naofumi Ishitobi, Tomoaki Sonobe, Masahiro Kameoka, Masanori Niki, and Yoshinori Mitamura

Recently, remarkable progress has been achieved in the development of medical equipment, and this study aimed to investigate and compare the efficacy of two machine-learning technologies with deep-learning (DL) and support vector machine (SVM) for the detection of branch retinal vein occlusion (BRVO) using ultrawide-field fundus images. The sensitivity, specificity, and area under the curve were calculated to compare the diagnostic abilities of the DL and SVM models. These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy.

近年来，医疗设备的发展取得了显著进步。该文旨在探究和对比两种机器学习技术：深度学习和支持向量机技术，利用超广角眼底镜来诊断视网膜分支静脉阻塞。通过计算其敏感性，特异性和曲线下面积来对比深度学习和支持向量机技术的诊断能力。研究结果表明采用深度学习技术联合超广角眼底镜检查能辨别患视网膜分支静脉阻塞眼，此方法准确度很高。

http://www.ijo.cn/en_publish/2019/1/20190115.pdf

Basic Research

Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia

全基因组DNA过甲基化和同型半胱氨酸增加近视的风险

Edward Hsi, Yung-Song Wang, Chia-Wei Huang, Ming-Lung Yu, Suh-Hang Hank Juo, Chung-Ling Liang

This study tested for the association between high myopia and LINE-1 methylation in leukocytes in 220 cases and 220 control subjects, then calculated the correlation of LINE-1 methylation levels between leukocyte DNA and ocular DNA in the mice. The results shows LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation. Dopamine can reduce both LINE-1 methylation and DNMT1 levels, which provides a novel mechanism for dopamine effect on myopia prevention.

该研究检测了220例高度近视患者和220名对照者白细胞LINE-1甲基化之间的关系，并计算了小鼠白细胞DNA和眼DNA LINE-1甲基化水平的相关性。结果表明，人类和小鼠的LINE-1过甲基化可能与高度近视有关。同型半胱氨酸和蛋氨酸在近视眼中积累，可能为全基因组甲基化提供多余的甲基。多巴胺可以降低LINE-1甲基化和DNMT1水平，为多巴胺预防近视提供了一种新的机制。

http://www.ijo.cn/en_publish/2019/1/20190106.pdf

Clinical Research

Comparison of ring 1 parameters in 37-segment multifocal electroretinography between onset and offset conditions of ring 2 to 4 in normal subjects

正常成年人37段多焦点视网膜电图中环1参数与环2~环4起点和终点检测情况的比较

Jun Ho Yoo, Cheolmin Yun, Jaeryung Oh, Seong-Woo Kim

The study aimed to investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography (mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. The results indicated that the lateral inhibition of the inner retina should be carefully considered in the context of expanded retinal geometry as well as histologic neural circuits.

该研究旨在探讨常规多焦视网膜电图(mfERG)试验中，中央六角形单元对黄斑区的反应是否与单中心六角形单元刺激下的mfERG相同。结果表明，在扩大视网膜几何结构和组织学神经回路的情况下，应仔细考虑内层视网膜的侧向抑制。

http://www.ijo.cn/en_publish/2019/1/20190111.pdf