Featured Articles in International Journal of Ophthalmology Vol.12 No.1, 2019

Clinical Research


Fluorescein angiography of retinal vascular involution after intravitreal injection of ranibizumab for retinopathy of prematurity


Yong Cheng, Tie-Gang Liu, Wei-Yi Li, Ming-Wei Zhao, Jian-Hong Liang


In the last years, anti-vascular endothelial growth factor (VEGF) treatment has been shown to be effective in treating retinopathy of prematurity (ROP). However, in a recent study, compared with laser-treated eyes, anti-VEGF treated eyes had significant residual vascular and macular abnormalities. Moreover, abnormal vascular patterns and large peripheral avascular areas may occur after anti-VEGF treatment for ROP. Although intravitreal ranibizumab can be very effective in ROP, we should remain cautious as infants may remain avascular peripheral retinas and abnormal vessel. Fluorescein angiography allows accurate visualization of vessel abnormalities in eyes with ROP, which will be helpful to affect assessment of disease activity and therapeutic effect.






Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion


Daisuke Nagasato, Hitoshi Tabuchi, Hideharu Ohsugi, Hiroki Masumoto, Hiroki Enno, Naofumi Ishitobi, Tomoaki Sonobe, Masahiro Kameoka, Masanori Niki, and Yoshinori Mitamura


Recently, remarkable progress has been achieved in the development of medical equipment, and this study aimed to investigate and compare the efficacy of two machine-learning technologies with deep-learning (DL) and support vector machine (SVM) for the detection of branch retinal vein occlusion (BRVO) using ultrawide-field fundus images. The sensitivity, specificity, and area under the curve were calculated to compare the diagnostic abilities of the DL and SVM models. These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy.





Basic Research


Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia


Edward Hsi, Yung-Song Wang, Chia-Wei Huang, Ming-Lung Yu, Suh-Hang Hank Juo, Chung-Ling Liang


This study tested for the association between high myopia and LINE-1 methylation in leukocytes in 220 cases and 220 control subjects, then calculated the correlation of LINE-1 methylation levels between leukocyte DNA and ocular DNA in the mice. The results shows LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation. Dopamine can reduce both LINE-1 methylation and DNMT1 levels, which provides a novel mechanism for dopamine effect on myopia prevention.

该研究检测了220例高度近视患者和220名对照者白细胞LINE-1甲基化之间的关系,并计算了小鼠白细胞DNA和眼DNA LINE-1甲基化水平的相关性。结果表明,人类和小鼠的LINE-1过甲基化可能与高度近视有关。同型半胱氨酸和蛋氨酸在近视眼中积累,可能为全基因组甲基化提供多余的甲基。多巴胺可以降低LINE-1甲基化和DNMT1水平,为多巴胺预防近视提供了一种新的机制。




Clinical Research


Comparison of ring 1 parameters in 37-segment multifocal electroretinography between onset and offset conditions of ring 2 to 4 in normal subjects


Jun Ho Yoo, Cheolmin Yun, Jaeryung Oh, Seong-Woo Kim


The study aimed to investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography (mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. The results indicated that the lateral inhibition of the inner retina should be carefully considered in the context of expanded retinal geometry as well as histologic neural circuits.




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