Clinical Research

Relationship between contrast sensitivity and corneal shape following overnight orthokeratology

角膜塑形术后对比敏感度及角膜形态的相关性

Li-Li Liu, Li-Ping Gong, Yue-Yuan Xu, Xuan Zhu,Kaddie Kwok Chen, Wei-Feng Liu

Orthokeratology (OK) can shape the cornea for reducing or eliminating refractive error. Meanwhlie, It may decrease the quality of vision detected by contrast sensitivity (CS). In this work, the researchers evaluated the CS changes after overnight OK lens and discuss which area changes of the shaping cornea effect CS. Tomographic images of the corneal surface were divided into three zones. From results, they got the conclusion: size of pupillary area in the corneal level; 3-mm surface irregularity indices and ratio of area crossover between the size of corneal changed by OK lens and pupillary area in the corneal level to the size of corneal changed by OK lens effected the logCS after OK. Maybe we need advanced design for OK lens to decrease the CS loss in order to better vision quality.

角膜塑形术(OK)通过角膜塑形以减轻或消除屈光不正。同时，也可能会降低视觉质量包括对比敏感度(CS)。研究人员通过评估配戴夜戴型OK镜后CS的变化，探讨了角膜塑形过程中哪些部分变化会影响CS。研究结果发现，角膜水平上的瞳孔面积大小；3-mm表面不规则指数；OK镜中央角膜压平区和角膜水平上的瞳孔面积的交叉区面积与OK镜中央角膜压平区之比对logCS有影响。这一结果可以作为新一代OK镜设计的指导，以减少CS损失，从而提高视觉质量。

http://www.ijo.cn/en_publish/2019/2/20190214.pdf

Clinical Research

Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study

青光眼滤过术后结膜下注射康柏西普：为期6个月随访的前瞻性随机干预试验研究

Jing Zhang, Vikash Vikash, Ping Wang, Tian Zheng, Dong-Lai Chen, Qing Wang, Min Ke

Currently, filtration surgery is one of the most commonly performed surgical intervention for glaucoma patients who cannot be adequately controlled with medication or laser treatments. This study outlines whether or not conbercept has any effects on scarring of filtration blebs, the variation of the IOP, the number of medications, the bleb characteristics and complications for the patients with glaucoma after filtration surgery to assess the safety and efficacy of subconjunctival injection conbercept. The results showed subconjunctival injection of conbercept has a safe, effective, and tolerable profile for open angle glaucoma patients after filtration surgery.

目前，对于用药物和激光手术无法完全控制的青光眼的患者来说，滤过手术是最常用的临床干预措施。该文旨在探究青光眼患者滤过术后结膜下注射康柏西普的安全性和有效性，对滤过泡疤痕，眼内压变化, 结膜滤泡形态特征和并发症的影响。结果表明青光眼患者滤过术后结膜下注射康柏西普是安全有效的。

http://www.ijo.cn/en_publish/2019/2/20190208.pdf

Clinical Research

Clinical outcomes with large macular holes using the tiled transplantation internal limiting membrane pedicle flap technique

带蒂内界膜转位术治疗黄斑大裂孔的临床结果

Li-Ping Wang, Wen-Tao Sun, Chun-Ling Lei, Jin Deng

The study aimed to report the surgical technique and efficacy of the tiled transplantation internal limiting membrane (ILM) pedicle flap technique after vitrectomy for 33 patients with large macular hole (MH). The results indicated that the tiled transplantation ILM pedicle flap technique provides bridge for retinal gliosis to achieve successful closures of the large MHs, and the microenvironment of this technique is more similar to the normal physiological conditions.

该研究报道了玻璃体切除术后带蒂内界膜转位术治疗33例黄斑大裂孔的疗效。结果表明，带蒂内界膜转位术为视网膜胶质细胞增生提供了成功闭合黄斑大裂孔的桥梁，该技术的微环境更接近正常生理条件。

http://www.ijo.cn/en_publish/2019/2/20190210.pdf

Clinical Research

SMILE intraoperative complications: incidence and management

SMILE术中并发症的发生率及处理

Abdelmonem M Hamed, Mohamed A Heikal, Tarek T. Soliman, Ahmed Daifalla, Khaled E Said-Ahmed

Small incision lenticule extraction (SMILE) procedure is to create a lenticule of corneal stroma using femtosecond laser, which is then extracted through a 3 mm incision. The main advantages of SMILE are to preserve the strong anterior corneal lamellae with a better long-term biochemical stability as well as less postoperative dry eye due to preservation of corneal nerve endings, and thus faster and more comfortable visual recovery. Although SMILE is a promising technique for the correction of myopia and myopic astigmatism with predictable, ef?cient, safe refractive and visual outcomes, complications can occur. For example, lost vacuum, treatment decentration, wound bleeding, incomplete bubble separation, the epithelial defects, incision tear, lenticule adherence to the cap, and cap perforation. More studies with a bigger number of eyes are required to efficiently evaluate the intraoperative complications and standardize their management strategies.

小切口透镜取出术（SMILE）应用飞秒激光制作角膜基质透镜，并通过3mm切口取出。其主要优点是保留了牢固的角膜基质前板层，具有较好的长期生物力学稳定性，由于保留了角膜神经末梢而减少了术后干眼，从而使视力恢复更快、更舒适。尽管SMILE是矫正近视和近视散光具有可预测、有效、安全的屈光和视力结果，但也可能发生并发症，例如：真空消失，偏心，伤口出血，不完全气泡分离，上皮缺损，切口撕裂，透镜-帽粘连，帽穿孔。为了有效地评估术中并发症并规范其治疗策略，还需要更多的研究。

http://www.ijo.cn/en_publish/2019/2/20190215.pdf