Featured Articles in International Journal of Ophthalmology Vol.12 No.3, 2019
 

Clinical Research

 

Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjögren’s syndrome

慢性眼移植物抗宿主病和Sjögren综合征患者睑板腺功能障碍的比较

Won Choi, Jun Young Ha, Ying Li, Jung Han Choi, Yong Sok Ji, Kyung Chul Yoon

 

The study investigated the abnormalities in the meibomian gland in patients with dry eye disease (DED) associated with chronic ocular graft-versus-host disease (coGVHD) in comparison with Sjögren’s syndrome (SS), a major form of aqueous deficient DED and meibomian gland dysfunction (MGD), a common cause of evaporative DED. Patients with DED associated with coGVHD showed poorer gland morphology and worse gland function than other types of DED. In addition, meibomian gland damage was not only associated with ocular surface damage but also disease severity of coGVHD.

该研究调查了干眼症(DED)患者中与慢性眼部移植物抗宿主病(coGVHD)相关的睑板腺的异常情况,并与常见的水样液缺乏性DED—Sjögren综合征和睑板腺功能障碍(MGD)导致的蒸发过强性DED进行了比较。与其他类型的DED患者相比,伴随coGVHDDED患者的腺体形态及功能较差。除此之外,睑板腺损伤不仅与眼表损伤有关,而且与coGVHD的严重程度有关。

http://www.ijo.cn/en_publish/2019/3/20190307.pdf



Basic Research

 

Construction of a full-thickness human corneal substitute from anterior acellular porcine corneal matrix and human corneal cells

脱细胞猪角膜前基质和人角膜细胞构建人角膜全层替代物

Kai Zhang, Xiao-Xiao Ren, Ping Li, Kun-Peng Pang, Hong Wang

 

The study aimed to construct a full-thickness human corneal replacement with anterior acellular porcine corneal matrix (AAPCM) lamellae, normal human keratocytes, epithelial cells, and human embryonic stem cells (hESC)-derived corneal endothelial cell-like cells, and the authors found that it had better biomechanical properties than a replacement constructed with posterior APCM in a new three-dimensional organ culture system which designed using a special suspending ring. The results indicated that AAPCM is an ideal scaffold for constructing full-thickness corneal replacement, and functional human full-thickness corneal replacements were successfully constructed using AAPCM and human corneal cells.

该研究应用脱细胞猪角膜前基质层(AAPCM),正常人角膜细胞,上皮细胞和人胚胎干细胞来源的角膜内皮样细胞构建人的角膜全层替代物。作者发现这种替代物比应用特殊的悬吊环的新型3D器官培养系统中构建的脱细胞猪角膜后基质具有更好的生物力学性能。AAPCM是构建角膜全层替代物的理想支架材料,利用AAPCM和人角膜细胞能够成功构建功能性人角膜全层替代物。

 

http://www.ijo.cn/en_publish/2019/3/20190301.pdf

 

 

Clinical Reaearch

 

Evaluation of outer retinal tubulations in diabetic macular edema underwent anti-VEGF treatment

抗血管内皮生长因子治疗糖尿病黄斑水肿外层视网膜管状结构的评价

Xiao-Li Huang, Yan-Ping Song, Qin Ding, Xiao Chen, Ling Hong

 

This study investigated the incidence and subsequent changes of outer retinal tubulations (ORTs) in diabetic macular edema (DME) underwent anti-vascular endothelial growth factor (VEGF) therapy, and to assess the possibility of ORT as a biomarker of DME severity or response to anti-VEGF therapy. The results showed that ORTs had a high incidence and changes over time in DME with anti-VEGF treatment and may be located at various retinal layers. Persistent ORT can be as a negative biomarker of outcome of DME.

该研究探讨糖尿病黄斑水肿患者行抗血管内皮生长因子治疗后外层视网膜管状结构的发生率及继发性变化,并评估外层视网膜管状结构作为糖尿病黄斑水肿严重程度或抗血管内皮生长因子治疗反应的生物标志物的可能性。结果表明,在抗血管内皮生长因子治疗糖尿病黄斑水肿时,外层视网膜管状结构具有较高的发生率和继发性变化,可能位于不同的视网膜层。持续性外层视网膜管状结构可作为糖尿病黄斑水肿预后的阴性生物标志物
 

http://www.ijo.cn/en_publish/2019/3/20190315.pdf

 

Basic Research

 

The protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-induced cell death and oxidative stress

玉米黄素对人体角膜缘和结膜上皮细胞保护作用:抑制紫外线诱导的细胞死亡和氧化应激

Huang Yue, Shi Chun, Li Jing

Zeaxanthin is a powerful antioxidant and effective photon absorber. Numerous studies have shown its effect in protecting retina from oxidative stress as a dietary supplement. The ocular surface is constantly exposed to harmful UV and oxidative stress from other sources. This study explored the protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-radiation and excessive oxidative stress. The results showed zeaxanthin is an effective reagent in reducing the detrimental effect of UV-radiation and oxidative stress on ocular surface epithelial cells.

玉米黄素是一种强大的抗氧化剂和有效的光子吸收剂。大量研究表明其作为膳食补充剂可以保护视网膜免受氧化应激的影响。眼表经常暴露在有害的紫外线和来自其他来源的氧化应激下。该研究揭示了玉米黄素抑制紫外线诱导的细胞死亡和氧化应激,进而对人体角膜缘和结膜上皮细胞产生保护作用,表明玉米黄素能够有效减少紫外线辐射和氧化应激对眼表上皮细胞的伤害。
 

http://www.ijo.cn/en_publish/2019/3/20190303.pdf

 

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