Featured Articles in International Journal of Ophthalmology Vol.12 No.3, 2019

Clinical Research


Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjögren’s syndrome


Won Choi, Jun Young Ha, Ying Li, Jung Han Choi, Yong Sok Ji, Kyung Chul Yoon


The study investigated the abnormalities in the meibomian gland in patients with dry eye disease (DED) associated with chronic ocular graft-versus-host disease (coGVHD) in comparison with Sjögren’s syndrome (SS), a major form of aqueous deficient DED and meibomian gland dysfunction (MGD), a common cause of evaporative DED. Patients with DED associated with coGVHD showed poorer gland morphology and worse gland function than other types of DED. In addition, meibomian gland damage was not only associated with ocular surface damage but also disease severity of coGVHD.



Basic Research


Construction of a full-thickness human corneal substitute from anterior acellular porcine corneal matrix and human corneal cells


Kai Zhang, Xiao-Xiao Ren, Ping Li, Kun-Peng Pang, Hong Wang


The study aimed to construct a full-thickness human corneal replacement with anterior acellular porcine corneal matrix (AAPCM) lamellae, normal human keratocytes, epithelial cells, and human embryonic stem cells (hESC)-derived corneal endothelial cell-like cells, and the authors found that it had better biomechanical properties than a replacement constructed with posterior APCM in a new three-dimensional organ culture system which designed using a special suspending ring. The results indicated that AAPCM is an ideal scaffold for constructing full-thickness corneal replacement, and functional human full-thickness corneal replacements were successfully constructed using AAPCM and human corneal cells.






Clinical Reaearch


Evaluation of outer retinal tubulations in diabetic macular edema underwent anti-VEGF treatment


Xiao-Li Huang, Yan-Ping Song, Qin Ding, Xiao Chen, Ling Hong


This study investigated the incidence and subsequent changes of outer retinal tubulations (ORTs) in diabetic macular edema (DME) underwent anti-vascular endothelial growth factor (VEGF) therapy, and to assess the possibility of ORT as a biomarker of DME severity or response to anti-VEGF therapy. The results showed that ORTs had a high incidence and changes over time in DME with anti-VEGF treatment and may be located at various retinal layers. Persistent ORT can be as a negative biomarker of outcome of DME.




Basic Research


The protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-induced cell death and oxidative stress


Huang Yue, Shi Chun, Li Jing

Zeaxanthin is a powerful antioxidant and effective photon absorber. Numerous studies have shown its effect in protecting retina from oxidative stress as a dietary supplement. The ocular surface is constantly exposed to harmful UV and oxidative stress from other sources. This study explored the protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-radiation and excessive oxidative stress. The results showed zeaxanthin is an effective reagent in reducing the detrimental effect of UV-radiation and oxidative stress on ocular surface epithelial cells.




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