Clinical Research
 

Retinal nerve fiber layer changes based on historic CD4 nadir among HIV positive patients undergoing glaucoma evaluation

阳性患者青光眼评估中基于历史最低CD4细胞计数观察视网膜神经纤维层的改变
 

Sarah H. Van Tassel, Paul Petrakos, Elizabeth Marlow, Elizabeth Mauer, Harjot K. Singh, Anna M. Demetriades
 

This study discussed relationships between retinal nerve fiber layer (RNFL) thickness and nadir CD4 cell count in human immunodeficiency virus (HIV) positive patients evaluated for glaucoma suspicion. The results showed patients with lower nadir CD4 cell counts have thicker RNFL in the superior and temporal quadrants compared to those with higher nadir CD4 counts. RNFL thickness in HIV positive patients may be affected by historic HIV disease control and should be considered when evaluating HIV positive patients for glaucoma.

该研究探讨了HIV阳性青光眼疑似患者视网膜神经纤维层厚度与最低CD4细胞计数的关系。结果表明，与最低CD4细胞计数较高的患者相比，最低CD4细胞计数较低的患者上方和颞侧象限的视网膜神经纤维层较厚。HIV阳性患者的视网膜神经纤维层厚度可能受到以往艾滋病毒疾病控制的影响，在评估HIV阳性患者是否患有青光眼时应予以考虑。

http://www.ijo.cn/en_publish/2019/5/20190514.pdf

Clinical Research
 

Efficacy and safety of micropulse laser trabeculoplasty for primary open angle glaucoma

微脉冲小梁激光成形术治疗原发性开角型青光眼的临床疗效及安全性研究

Ying Hong, Si-Jia Song, Bo Liu, Kiana Hassanpour, Chun Zhang, Nils Loewen
 

This study evaluated the efficiency and safety of micropulse laser trabeculoplasty (MLT) for primary open angle glaucoma (POAG) patients. The intraocular pressure (IOP) and the number of glaucoma medications of POAG patients before and after MLT treatment were compared. The results showed that MLT was effective and safe for POAG patients. There was also no IOP spike or other complications after MLT and the IOP 6mo after treatment decreased significantly with less glaucoma medication.

该文旨在研究微脉冲小梁激光成形术治疗原发性开角型青光眼的疗效及其安全性。作者对原发性开角型青光眼患者术前术后的眼压和用药情况进行了对比，结果表明微脉冲小梁激光成形术安全有效，且术后未出现眼压骤升及其他并发症。术后6个月患者眼压显著下降且药物用量减少。

http://www.ijo.cn/en_publish/2019/5/20190513.pdf

Investigation
 

Task sharing: situation analysis about capacity and resources for management of diabetic retinopathy in Pakistan

任务共担：巴基斯坦应对糖尿病视网膜病变的能力与资源状况分析

Mufarriq Shah, Ayesha Noor, C Alex Harper, Jill Elizabeth Keeffe

The shortage of human resources for health care is a severe constraint to universal access to eye care services and specifically for people with diabetes, particularly in low resource countries. This challenge is further exacerbated by the global increase in prevalence of diabetes and resulting diabetic retinopathy (DR). Task sharing is proposed as a system-based approach to meet the widening gap between the need and supply of eye care workers to manage eye care services for people with diabetes in low resource countries.

医护人员短缺严重制约了眼科医疗服务的普及，尤其是资源匮乏国家中的糖尿病患者。全球糖尿病患病率的增长和由此引发的糖尿病视网膜病变患病率使这一状况进一步加剧。该文提出了任务共担这种系统性方法来填补日益扩大的眼科医护人员供需差距，以解决在资源匮乏国家中糖尿病患者所需的眼科医疗资源。

http://www.ijo.cn/en_publish/2019/5/20190517.pdf

Basic Research

Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis
降钙素基因相关肽在小鼠烟曲霉角膜炎中的表达及作用

Min Yin, Cui Li, Xu-Dong Peng, Gui-Qiu Zhao, Yuan Wu, Heng-Rui Zheng, Qian Wang, Qiang Xu, Nan Jiang

The study aimed to investigate the expression and role of calcitonin gene-related peptide (CGRP) in the mouse models induced by Aspergillus fumigatus (A. fumigatus). The cornea expression of CGRP was significantly elevated in C57BL/6 mice corneas and macrophages after A. fumigatus infection. After treatment with exogenous CGRP, the levels of IL-1β, TNF-α and IL-6 were reduced, and IL-10 level was increased in the A. fumigatus stimulated-macrophages. However, IL-1β, TNF-α and IL-6 levels were upregulated after pretreatment of CGRP8-37. But the mRNA levels of MIP-2, TGF-β and IL-10 were not changed. The results indicated that A. fumigatus increased CGRP expression. CGRP may play a protective role against inflammation in A. fumigatus keratitis

该研究旨在探讨降钙素基因相关肽(CGRP)在烟曲霉诱导的小鼠模型的表达及其作用。烟曲霉感染C57BL/6小鼠角膜或巨噬细胞后，CGRP表达明显升高。外源性CGRP处理后，烟曲霉诱导的巨噬细胞中IL-1β、TNF-α及IL-6的水平降低，IL-10水平升高。而CGRP8-37 (CGRP受体的拮抗剂)预处理后，IL-1β、TNF-α和IL-6水平上调，MIP-2、TGF-β和IL-10在mRNA水平无任何变化。结果表明，烟曲霉可致CGRP表达升高。CGRP可能对于烟曲霉角膜炎具有抗炎作用。

http://www.ijo.cn/en_publish/2019/5/20190501.pdf