Featured Articles in International Journal of Ophthalmology Vol.12 No.5, 2019

Clinical Research

Retinal nerve fiber layer changes based on historic CD4 nadir among HIV positive patients undergoing glaucoma evaluation


Sarah H. Van Tassel, Paul Petrakos, Elizabeth Marlow, Elizabeth Mauer, Harjot K. Singh, Anna M. Demetriades

This study discussed relationships between retinal nerve fiber layer (RNFL) thickness and nadir CD4 cell count in human immunodeficiency virus (HIV) positive patients evaluated for glaucoma suspicion. The results showed patients with lower nadir CD4 cell counts have thicker RNFL in the superior and temporal quadrants compared to those with higher nadir CD4 counts. RNFL thickness in HIV positive patients may be affected by historic HIV disease control and should be considered when evaluating HIV positive patients for glaucoma.





Clinical Research

Efficacy and safety of micropulse laser trabeculoplasty for primary open angle glaucoma


Ying Hong, Si-Jia Song, Bo Liu, Kiana Hassanpour, Chun Zhang, Nils Loewen

This study evaluated the efficiency and safety of micropulse laser trabeculoplasty (MLT) for primary open angle glaucoma (POAG) patients. The intraocular pressure (IOP) and the number of glaucoma medications of POAG patients before and after MLT treatment were compared. The results showed that MLT was effective and safe for POAG patients. There was also no IOP spike or other complications after MLT and the IOP 6mo after treatment decreased significantly with less glaucoma medication.






Task sharing: situation analysis about capacity and resources for management of diabetic retinopathy in Pakistan


Mufarriq Shah, Ayesha Noor, C Alex Harper, Jill Elizabeth Keeffe

The shortage of human resources for health care is a severe constraint to universal access to eye care services and specifically for people with diabetes, particularly in low resource countries. This challenge is further exacerbated by the global increase in prevalence of diabetes and resulting diabetic retinopathy (DR). Task sharing is proposed as a system-based approach to meet the widening gap between the need and supply of eye care workers to manage eye care services for people with diabetes in low resource countries.






Basic Research

Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis


Min Yin, Cui Li, Xu-Dong Peng, Gui-Qiu Zhao, Yuan Wu, Heng-Rui Zheng, Qian Wang, Qiang Xu, Nan Jiang

The study aimed to investigate the expression and role of calcitonin gene-related peptide (CGRP) in the mouse models induced by Aspergillus fumigatus (A. fumigatus). The cornea expression of CGRP was significantly elevated in C57BL/6 mice corneas and macrophages after A. fumigatus infection. After treatment with exogenous CGRP, the levels of IL-1β, TNF-α and IL-6 were reduced, and IL-10 level was increased in the A. fumigatus stimulated-macrophages. However, IL-1β, TNF-α and IL-6 levels were upregulated after pretreatment of CGRP8-37. But the mRNA levels of MIP-2, TGF-β and IL-10 were not changed. The results indicated that A. fumigatus increased CGRP expression. CGRP may play a protective role against inflammation in A. fumigatus keratitis

该研究旨在探讨降钙素基因相关肽(CGRP)在烟曲霉诱导的小鼠模型的表达及其作用。烟曲霉感染C57BL/6小鼠角膜或巨噬细胞后,CGRP表达明显升高。外源性CGRP处理后,烟曲霉诱导的巨噬细胞中IL-1βTNF-αIL-6的水平降低,IL-10水平升高。而CGRP8-37 (CGRP受体的拮抗剂)预处理后,IL-1βTNF-αIL-6水平上调,MIP-2TGF-βIL-10mRNA水平无任何变化。结果表明,烟曲霉可致CGRP表达升高。CGRP可能对于烟曲霉角膜炎具有抗炎作用。



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