Highlighted Articles in Int J Ophthalmol Vol.12 No.6 2019

Basic Research

Effects of the long wavelength-filtered continuous spectrum on natural refractive development in juvenile guinea pigs


Rui-Qin Li, Wei-Zhong Lan, Xiao-Ning Li, Hao-Ran Wu, Qing-Lin Xu, Hong Zhong, Wen-Tao Li, Zhi-Kuan Yang

This study investigated the effects of spectral composition and light intensity on natural refractive development in guinea pigs. Guinea pigs were raised under different conditions to see how differences in spectral composition and light intensity in a continuous spectrum affect refractive development. The results suggested that under high-intensity lighting, high light intensity, not spectrum distributions, inhibited axial growth. Under medium- and low-intensity lighting, filtering out the long wavelength inhibited axial growth in juvenile guinea pigs.



Clinical Research


Focal choroidal excavation complicated with choroidal neovascularization in young and middle aged patients


Wen-Yi Tang, Ting Zhang, Qin-Meng Shu, Chun-Hui Jiang, Qing Chang, Hong Zhuang, Ge-Zhi Xu

This study investigated the clinical and optical coherence tomography (OCT) features of focal choroidal excavation (FCE) complicated with choroidal neovascularization (CNV) in young and middle aged patients. The results showed that after anti-vascular endothelial growth factor (anti-VEGF) therapy, the central retinal thickness was significantly reduced and the best-corrected visual acuity (BCVA) was significantly improved. FCE may be an important reason to cause CNV. Especially in young patients with idiopathic CNV, we should pay attention to the use of OCT to check the presence of FCE. Anti-VEGF therapy is generally effective for CNV associated with FCE.





Basic Research


Effects of astaxanthin on antioxidant parameters in ARPE-19 cells on oxidative stress model


The study aimed to observe the protective effect of astaxanthin against hydroquinone mediated cell death in the apoptotic cascade and evaluating intracellular Ca2+ release, caspase-3, and -9 activation, reactive oxygen species production in ARPE-19 cells. The authors found that ARPE-19 cells are avoided from hydroquinone-induced reactive oxygen species production and caspase-3 and -9 activation by astaxanthin. Astaxanthin may limit the range of caspase synthesis, Ca2+ release and excess production of reactive oxygen species with antiapoptotic effect. This study proposes a new therapeutic approach for the treatment of age-related macular degeneration.






Review Article

Visual problems: A review of prevalence studies on visual impairment in school-age children


Uchenna C. Atowa, Rekha Hansraj, Samuel O. Wajuihian

The present review highlights gaps in the knowledge of the prevalence and causes of visual impairment in school-age children and emphasised on the need for additional research in this area of study. The review also reveals regional variations in the prevalence of visual impairment. These variations may be attributed to differences in socioeconomic development, race, cultural factors, as well as, availability of interventions. Considering the implication of visual anomalies to academic achievement, as well as overall well-being, the review could provide useful information for policy-makers and can help in planning, provision and evaluation of child health services.



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