Highlighted Articles in Int J Ophthalmol Vol.12 No.8 2019

Basic Research


Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina


Takahiro Kurose, Eriko Sugano, Akihisa Sugai, Raki Shiraiwa, Mariyo Kato, Yoko Mitsuguchi, Yoshihiro Takai, Kitako Tabata, Yoichi Honma, Hiroshi Tomita


The authors report the protective effect of ClearVision EX® (CV) against N-methyl-D-aspartate (NMDA)-induced retinal toxicity. CV has a protective effect against non-related glutamate receptor-induced oxidative stress. NMDA-induced retinal damage is inhibited by the oral administration of CV. The increased phosphorylated extracellular signal-regulated kinase in the Müller cells plays a key role in the protective effect.

作者报道膳食补充剂ClearVision EX®(CV)N-甲基-D-天冬氨酸(NMDA)诱导的视网膜毒性的保护作用。口服CV对非相关谷氨酸受体诱导的氧化应激具有保护作用,并且可抑制NMDA诱导的视网膜损伤。Müller细胞中磷酸化细胞外信号调节激酶的增加在保护作用中起着关键作用。






Evaluating correlation between the ocular biometry and genetic variants of MYOC and ABCA1 with primary angle-closure glaucoma in a cohort from northern China


Shao-Lin Wang, Shun-Yu Piao, Man-Yun Xu, Wen Zhang, Jian-Qing Ma, Juan Hao, Hao Chi, Zhong-Qi Xue, Shao-Ping Ha, Wen-Juan Zhuang


This study investigated whether the gene variants in MYOC and ABCA1 are associated with primary angle-closure glaucoma (PACG) and anterior chamber depth (ACD) and axial length (AL) in samples from northern China. The result showed two SNPs rs183532 and rs235875 as well as a haplotype TTC in MYOC were nominally associated with PACG despite the significance was lost after Bonferroni correction. No association was observed between ABCA1 and PACG, neither did the association between these variants and ACD as well as AL. The present study suggests MYOC and ABCA1 do not play a part in the pathogenesis of PACG as well as the regulation of ocular biometric parameters in a northern Chinese population. Further investigations with large sample size are needed to verify this consequence.

该研究调查了中国北方地区原发性闭角型青光眼、前房深度和眼轴长度是否与MYOCABCA1基因变异有关。结果表明MYOC中有两个SNPs, rs183532rs235875以及一个单倍型TTC与原发性闭角型青光眼有名义上的关联,但Bonferroni校正后其显著性消失。ABCA1与原发性闭角型青光眼无相关性,同时这些变异也与前房深度和眼轴长度无相关性。该研究显示MYOCABCA1在中国北方人群原发性闭角型青光的发病机制以及眼生物特征参数的调控中并未发挥作用。这一结果还需要进一步的大样本研究来验证。






Atropine 0.01% eye drops slow myopia progression: a systematic review and Meta-analysis


Ying Zhao, Kai Feng, Rui-Bao Liu, Jin-Hua Pan, Lai-Lin Zhang, Zhu-Ping Xu, Xue-Jing Lu


The study aimed to evaluate the effects of atropine 0.01% on slowing myopia progression. The authors compared the results from seven randomized controlled trials the effect of atropine 0.01% in slowing myopia progression. The results showed that atropine had a lower incidence of adverse events and well tolerated without an adverse effect on vision-related quality of life. Based on the available evidence, atropine 0.01% eye drops offer benefits in controlling axial growth and safety without causing significant differences in diopter values, distance vision and intraocular pressure.




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