Basic Research

Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells

小白菊内酯抑制人葡萄膜黑色素瘤细胞增殖并诱导其凋亡的研究

Song-Tian Che, Li Bie, Xu Li, Hui Qi, Peng Yu, Ling Zuo

Parthenolide is the main extract of Chinese herbal medicine parthenium hysterophorus. This study aims to explore the effect of parthenolide on human uveal melanoma cells (C918 and SP6.5 cells) and its molecular mechanism. The results show that parthenolide inhibited proliferation and induced apoptosis of C918 cells by arresting G1 phase and regulating mitochondrial pathway, and the reduction was more noticeable in C918 cells than in SP6.5 cells, however, parthenolide did not affect normal cells.

小白菊内酯是中草药小白菊的主要提取物。该研究旨在探讨小白菊内酯对人葡萄膜黑色素瘤细胞（C918和SP6.5细胞）的作用及其分子机制。结论表明小白菊内酯通过阻滞G1期和调节线粒体途径抑制C918细胞增殖和诱导凋亡，C918比SP6.5细胞减少更明显，但对正常细胞没有影响。

http://www.ijo.cn/en_publish/2019/10/20191003.pdf

Review Article

New approaches for diagnosis of dry eye disease

干眼症诊断新方法

Abdelrahman M. Elhusseiny, Ali A. Khalil, Reem H. El Sheikh, Mohammad A. Bakr, Mohamed Gaber Eissa, Yasmine M. El Sayed

This article reviewed the literature for different diagnostic approaches for dry eye disease (DED) including the most recent advances, contradictions and promising diagnostic tools and technique, as well as assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis.

该文章回顾了文献中诊断干眼病的不同方法，包括最新的进展，争论以及有望成功的诊断方法和技术，以及泪液渗透性，泪膜稳定性，眼生物标记评估等。根据所测量的参数，诊断方法可以分为泪膜渗透压、视功能、泪液量、泪液代谢、泪膜稳定性、泪膜成分、眼生物标记物等。未来的研究应该集中在识别和测量最具体的干眼症诊断参数。

http://www.ijo.cn/en_publish/2019/10/20191015.pdf

 Review Article

Progression on canaloplasty for primary open angle glaucoma

原发性开角型青光眼粘小管成形术研究进展

Jun Zhang, Ning-Li Wang

The article is reviewed research progress on canaloplasty for primary open angle glaucoma. It includes the traditional canaloplasty and newly developed Ab-interno canaloplasty. It contains the mechanisms of reconstruction of aqueous humor in detail and its characteristics, prospects of canaloplasty such as gene therapy in the future.

该文就原发性开角型青光眼的粘小管成形术的研究进展作一综述。包括传统的粘小管成形术和近期发展起来的内路粘小管成形术。详细介绍了房水重建的机制，房水重建的特点，基因治疗等粘小管成形术的发展前景。

http://www.ijo.cn/en_publish/2019/10/20191016.pdf

Clinical Research

Comparison of ocular parameters of two biometric measurement devices in highly myopic eyes

比较两种生物测量仪在高度近视患者的眼部参数

Xiao-Xiao Guo, Ran You, Shan-Shan Li, Xiu-Fen Yang, Lu Zhao, Fan Zhang, Yan-Ling Wang, Xi Chen

The study aimed to compare the output of the Tomey OA-2000 and IOLMaster using patients with high myopia as subjects and observe whether the longer eye axis affects the calculation of IOL power. For the control group, the Bland-Altman analysis showed the 95% limits of agreement (LoA) for most parameters including: axial length (AL), anterior chamber depth (ACD), keratometry (K), and white to white (WTW; -0.24 to 0.29 mm, -0.22 to 0.45 mm, -0.39 to 0.31 D, and -0.90 to 0.86 mm, respectively). For the high myopia group, the Bland-Altman analysis showed the 95% LoA: AL, ACD, K, and WTW (-0.34 to 0.32 mm, -0.36 to 0.34 mm, -0.57 to 0.47 D, -0.80 to 0.68 mm, respectively). And there were no statistically significant differences between two instruments (P>0.05). Theresults show that most parameters acquired by the OA-2000 were comparable to those obtained by the IOLMaster, including the AL, ACD, and K values. Among them, the agreement of the high myopia group was poor compared to the control group.

该研究以高度近视患者为研究对象，比较Tomey OA-2000与IOLMaster的测量结果，观察长眼轴是否影响IOL的计算。Bland-Altman分析显示，对照组AL、ACD、K和WTW的95% LoA分别为-0.24­-0.29 mm、-0.22-0.45 mm、-0.39-0.31 D和-0.90-0.86 mm。高度近视组分别为-0.34-0.32 mm、-0.36-0.34 mm、-0.57-0.47 D、-0.80-0.68 mm。两组比较差异无统计学意义（P>0.05）。结果表明OA-2000与IOLMaster获得的参数基本一致，包括AL、ACD和K，且高度近视组的一致性较差。

http://www.ijo.cn/en_publish/2019/10/20191005.pdf