Highlighted Articles in Int J Ophthalmol Vol.12 No.10 2019

Basic Research

Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells


Song-Tian Che, Li Bie, Xu Li, Hui Qi, Peng Yu, Ling Zuo


Parthenolide is the main extract of Chinese herbal medicine parthenium hysterophorus. This study aims to explore the effect of parthenolide on human uveal melanoma cells (C918 and SP6.5 cells) and its molecular mechanism. The results show that parthenolide inhibited proliferation and induced apoptosis of C918 cells by arresting G1 phase and regulating mitochondrial pathway, and the reduction was more noticeable in C918 cells than in SP6.5 cells, however, parthenolide did not affect normal cells.




Review Article


New approaches for diagnosis of dry eye disease


Abdelrahman M. Elhusseiny, Ali A. Khalil, Reem H. El Sheikh, Mohammad A. Bakr, Mohamed Gaber Eissa, Yasmine M. El Sayed


This article reviewed the literature for different diagnostic approaches for dry eye disease (DED) including the most recent advances, contradictions and promising diagnostic tools and technique, as well as assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis.





 Review Article

Progression on canaloplasty for primary open angle glaucoma


Jun Zhang, Ning-Li Wang


The article is reviewed research progress on canaloplasty for primary open angle glaucoma. It includes the traditional canaloplasty and newly developed Ab-interno canaloplasty. It contains the mechanisms of reconstruction of aqueous humor in detail and its characteristics, prospects of canaloplasty such as gene therapy in the future.





Clinical Research


Comparison of ocular parameters of two biometric measurement devices in highly myopic eyes


Xiao-Xiao Guo, Ran You, Shan-Shan Li, Xiu-Fen Yang, Lu Zhao, Fan Zhang, Yan-Ling Wang, Xi Chen


The study aimed to compare the output of the Tomey OA-2000 and IOLMaster using patients with high myopia as subjects and observe whether the longer eye axis affects the calculation of IOL power. For the control group, the Bland-Altman analysis showed the 95% limits of agreement (LoA) for most parameters including: axial length (AL), anterior chamber depth (ACD), keratometry (K), and white to white (WTW; -0.24 to 0.29 mm, -0.22 to 0.45 mm, -0.39 to 0.31 D, and -0.90 to 0.86 mm, respectively). For the high myopia group, the Bland-Altman analysis showed the 95% LoA: AL, ACD, K, and WTW (-0.34 to 0.32 mm, -0.36 to 0.34 mm, -0.57 to 0.47 D, -0.80 to 0.68 mm, respectively). And there were no statistically significant differences between two instruments (P>0.05). Theresults show that most parameters acquired by the OA-2000 were comparable to those obtained by the IOLMaster, including the AL, ACD, and K values. Among them, the agreement of the high myopia group was poor compared to the control group.


该研究以高度近视患者为研究对象,比较Tomey OA-2000IOLMaster的测量结果,观察长眼轴是否影响IOL的计算。Bland-Altman分析显示,对照组ALACDKWTW95% LoA分别为-0.24­-0.29 mm-0.22-0.45 mm-0.39-0.31 D-0.90-0.86 mm。高度近视组分别为-0.34-0.32 mm-0.36-0.34 mm-0.57-0.47 D-0.80-0.68 mm。两组比较差异无统计学意义(P>0.05)。结果表明OA-2000IOLMaster获得的参数基本一致,包括ALACDK,且高度近视组的一致性较差。



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