Highlighted Articles in Int J Ophthalmol Vol.12 No.12 2019

Basic Research

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway


Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li

This study aims to explore the activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway in high glucose condition and investigate its role in the apoptosis of rabbit corneal epithelial cells (RCECs) by an in vitro model. And the results showed that PERK-eIF2α-CHOP-caspase12 pathways were activated in high glucose-induced RECEs and mainly involved in the early stages of cell apoptotic. This might explain why the incidence of dry eye is high in diabetic and dry eye symptoms. The injury severity of RECEs is related to the concentration or time of glucose. This work will help guide the early prevention and treatment of diabetes-related dry eye.




Clinical Research

Chorioretinal response to intravitreal aflibercept injection in acute central serous chorioretinopathy


Byung Ju Jung, Kook Lee, Jin Hyung Park, Jae Hyung Lee

The purpose of this study was to investigate the short-term response to intravitreal aflibercept injection in patients with acute central serous chorioretinopathy (CSC) by focusing on chorioretinal changes. Although intravitreal aflibercept injections are widely known to be effective for the resolution of exudative changes in age-related macular degeneration, it is uncertain whether aflibercept has direct influence on the underlying choroid. In the current study, we observed a rebound phenomenon of subfoveal choroidal thickness and subretinal fluid at 2 or 3mo after a single aflibercept injection in about half of the acute CSC patients. This fluctuation signifies that aflibercept can reduce the exudation from hyperpermeable choriocapillaris in acute CSC and lead to the reduction of subretinal fluid, which increase again as the effects of the drug diminishes.




Clinical Research

The effects of implantable collamer lens implantation on higher order aberrations


Belma Kayhan, Efekan Coskunseven, Onurcan Sahin, Ioannis Pallikaris

This study evaluated the changes in higher order aberrations (HOAs) after implantable collamer lens (ICL) implantation. Totally 30 eyes of 18 patients with myopia were included in this study with an average age of 25.77. Refraction, uncorrected distance visual acuity, corrected distance visual acuity, HOAs (entire, corneal and internal) were evaluated preoperatively and three months postoperatively. The results showed ICL implantation corrects the refractive error successfully and changes entire and internal HOAs of the eye.




Clinical Research

Impact of corneal parameters on intraocular pressure measurements in different tonometry methods


Aleksandra Zakrzewska, Marta P. Wi?cek, Anna Machalińska

The study aimed to evaluate the impact of central corneal thickness (CCT) and corneal curvature on intraocular pressure (IOP) measurements performed by three different tonometers. First, the examination of corneal curvature and CCT were performed sequentially. Then, the IOP examination was performed with three different tonometry techniques in following order: Goldmann applanation tonometer, Pascal dynamic contour tonometer, and ICare rebound tonometer. The results show that the same method should always be chosen for routine IOP control, and measurements obtained by different methods cannot be compared. All analysed tonometry methods are dependent on CCT; thus, CCT should be taken into consideration for both diagnostics and monitoring.




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