Basic Research

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway

高糖诱导兔角膜上皮细胞凋亡及PERK-eIF2α-CHOP-caspase-12信号通路的激活

Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li

This study aims to explore the activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway in high glucose condition and investigate its role in the apoptosis of rabbit corneal epithelial cells (RCECs) by an in vitro model. And the results showed that PERK-eIF2α-CHOP-caspase12 pathways were activated in high glucose-induced RECEs and mainly involved in the early stages of cell apoptotic. This might explain why the incidence of dry eye is high in diabetic and dry eye symptoms. The injury severity of RECEs is related to the concentration or time of glucose. This work will help guide the early prevention and treatment of diabetes-related dry eye.

该研究通过体外模型的方法，探讨高糖状态下PERK-eIF2α-CHOP-caspase-12信号通路的激活及其在兔角膜上皮细胞凋亡中的作用。结果表明PERK-eIF2α-CHOP-caspase12通路在高糖诱导的RECEs中被激活并主要参与了细胞凋亡的早期阶段

，这也许可以解释为什么干眼在糖尿病和干眼症中的发病率很高。因为RECEs的损伤程度与葡萄糖浓度或时间有关，所以该研究结果将有助于指导糖尿病相关性干眼症的早期防治。

http://www.ijo.cn/en_publish/2019/12/20191201.pdf

Clinical Research

Chorioretinal response to intravitreal aflibercept injection in acute central serous chorioretinopathy

急性中心性浆液性脉络膜视网膜病变玻璃体腔内注射阿柏西普后的脉络膜视网膜反应

Byung Ju Jung, Kook Lee, Jin Hyung Park, Jae Hyung Lee

The purpose of this study was to investigate the short-term response to intravitreal aflibercept injection in patients with acute central serous chorioretinopathy (CSC) by focusing on chorioretinal changes. Although intravitreal aflibercept injections are widely known to be effective for the resolution of exudative changes in age-related macular degeneration, it is uncertain whether aflibercept has direct influence on the underlying choroid. In the current study, we observed a rebound phenomenon of subfoveal choroidal thickness and subretinal fluid at 2 or 3mo after a single aflibercept injection in about half of the acute CSC patients. This fluctuation signifies that aflibercept can reduce the exudation from hyperpermeable choriocapillaris in acute CSC and lead to the reduction of subretinal fluid, which increase again as the effects of the drug diminishes.

该研究的目的是通过观察急性中心性浆液性脉络膜视网膜病变(CSC)患者的脉络膜视网膜改变，探讨玻璃体腔注射阿柏西普的短期疗效。虽然玻璃体腔注射阿柏西普对解决年龄相关黄斑变性的渗出性改变是有效的，但是阿柏西普是否对脉络膜有直接影响尚不明确。在目前的研究中，我们观察到大约一半的急性CSC患者在单次注射阿柏西普后2月或3月出现了黄斑中心凹下脉络膜厚度和视网膜下液的反弹现象。这种波动意味着阿柏西普可以减少急性CSC中高渗性脉络膜毛细血管渗出，导致视网膜下液减少，随着药物作用的减弱，视网膜下液随之增加。

http://www.ijo.cn/en_publish/2019/12/20191208.pdf

Clinical Research

The effects of implantable collamer lens implantation on higher order aberrations

ICL植入对高阶像差的影响

Belma Kayhan, Efekan Coskunseven, Onurcan Sahin, Ioannis Pallikaris

This study evaluated the changes in higher order aberrations (HOAs) after implantable collamer lens (ICL) implantation. Totally 30 eyes of 18 patients with myopia were included in this study with an average age of 25.77. Refraction, uncorrected distance visual acuity, corrected distance visual acuity, HOAs (entire, corneal and internal) were evaluated preoperatively and three months postoperatively. The results showed ICL implantation corrects the refractive error successfully and changes entire and internal HOAs of the eye.

该研究评估了ICL植入术后高阶像差的变化。研究共纳入18例近视患者共30只眼，平均年龄25.77岁，分别于术前与术后3个月评估屈光、裸眼视力、矫正视力、高阶像差（全眼、角膜、内眼）。结果表明，ICL植入术成功地矫正了屈光不正，并且改变了全眼和内眼的高阶像差。

http://www.ijo.cn/en_publish/2019/12/20191205.pdf

Clinical Research

Impact of corneal parameters on intraocular pressure measurements in different tonometry methods

不同眼压测量方法中角膜参数对眼压测量的影响

Aleksandra Zakrzewska, Marta P. Wi?cek, Anna Machalińska

The study aimed to evaluate the impact of central corneal thickness (CCT) and corneal curvature on intraocular pressure (IOP) measurements performed by three different tonometers. First, the examination of corneal curvature and CCT were performed sequentially. Then, the IOP examination was performed with three different tonometry techniques in following order: Goldmann applanation tonometer, Pascal dynamic contour tonometer, and ICare rebound tonometer. The results show that the same method should always be chosen for routine IOP control, and measurements obtained by different methods cannot be compared. All analysed tonometry methods are dependent on CCT; thus, CCT should be taken into consideration for both diagnostics and monitoring.

该研究旨在探讨中央角膜厚度（CCT）和角膜曲率对三种不同眼压计测量眼压（IOP）的影响。作者首先对参与者进行角膜曲率和CCT检查，并依次采用Goldmann压平眼压计、Pascal动态轮廓眼压计和ICare回弹式眼压计三种不同的眼压测量技术进行眼压检查。结果表明，常规眼压检查应始终选用同一种方法，用不同方法得到的测量结果无法比较，所有分析的眼压测量方法都依赖于CCT。因此，在诊断和监测时都应考虑CCT。

http://www.ijo.cn/en_publish/2019/12/20191206.pdf