Featured Articles in International Journal of Ophthalmology Vol.13 No.1, 2020

Clinical Research

Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group


This study aims to compare two different anti-vascular endothelial growth factor (anti-VEGF) treatment regimens’a priori pro re nata (1+PRN) and 3 consecutive intravitreal injections followed by a PRN regimen (3+PRN)—anatomical and functional results in neovascular age-related macular degeneration (nAMD) patients, and evaluate the treatment outcomes from nine tertiary retinal centers and to investigate the effect of initial regimen preferences based on our real life experience. The results show that the loading dose of anti-VEGF treatments in nAMD leads to significantly better anatomical and functional results, regardless of the agent, especially in early follow-up interval.



Clinical Research

Ocular bacterial infections at a tertiary eye center in China: a 5-year review of pathogen distribution and antibiotic sensitivity


Wen Gao, Tian Xia, Hua-Bo Chen, Xiao-Jing Pan, Yu-Sen Huang, Xin Wang, Yan-Ling Dong, Li-Xin Xie


The study aims to provide statistical evidence for the use of antibiotics in ophthalmology by assessing the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections. Staphylococcus epidermidis is the predominant isolate in all ocular specimens with bacteria. Gatifloxacin is more suitable for topical prophylactic use than levofloxacin in ophthalmology when necessary. Vancomycin and fusidic acid both have better effects on gram-positive bacteria than gram-negative bacteria. More accurate antibiotic sensitivity analysis results can be obtained when a more detailed bacterial classification and more appropriate statistical methods are performed.




Clinical Research

Comparative clinical outcomes of Tecnis toric IOL implantation in femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery

飞秒激光辅助与常规超声乳化Tecnis toric人工晶状体植入术的临床比较

Kai-Ran Lai, Xiao-Bo Zhang, Yin-Hui Yu, Ke Yao

The study aimed to compare the short-term visual outcomes, residual refractive cylinder, and rotation stability after Tecnis toric intraocular lens (IOL) implantation during femtosecond laser-assisted cataract surgery (Femto phaco) and conventional phacoemulsification surgery (Conventional phaco). The results show that the Femto phaco group has significantly more subjects with the residual astigmatism of ≤1 D, but there are no significant differences in rotation stability and visual outcomes as compared with the Conventional phaco group after the application of the Tecnis toric IOL in this cohort.

该研究旨在比较飞秒激光辅助白内障手术(Femto phaco)与常规超声乳化白内障手术(Conventional phaco)植入Tecnis toric人工晶状体后的短期视力、残余散光度数及旋转稳定性。结果表明,Femto phacoTecnis toric人工晶状体术后残余散光≤1 D的患者更多,与Conventional phaco组相比,术后旋转稳定性和视力则无明显差异。



Clinical Research

Different modes of foveal regeneration after closure of full-thickness macular holes by (re)vitrectomy and autologous platelet concentrate


Andreas Bringmann, Claudia Jochmann, Jan Darius Unterlauft, Renate Wiedemann, Matus Rehak, Peter Wiedemann

This study described using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana (re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. The data show that there are different modes of foveal regeneration after closure of macular holes with (re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and retinal pigment epithelial cells.



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