Featured Articles in International Journal of Ophthalmology Vol.13 No.1, 2020

Clinical Research

Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group

两种不同治疗方案对土耳其人群新生血管年龄相关性黄斑变性的疗效比较基于Bosphorus-RWE研究小组的真实数据

This study aims to compare two different anti-vascular endothelial growth factor (anti-VEGF) treatment regimens’a priori pro re nata (1+PRN) and 3 consecutive intravitreal injections followed by a PRN regimen (3+PRN)—anatomical and functional results in neovascular age-related macular degeneration (nAMD) patients, and evaluate the treatment outcomes from nine tertiary retinal centers and to investigate the effect of initial regimen preferences based on our real life experience. The results show that the loading dose of anti-VEGF treatments in nAMD leads to significantly better anatomical and functional results, regardless of the agent, especially in early follow-up interval.

该文旨在对比两种不同的抗血管内皮生长因子的治疗方案:首先进行1次玻璃体腔注射后进行按需注射(1+PRN)方案和连续3次玻璃体腔注射后进行按需注射3+PRN方案对新生血管年龄相关性黄斑变性(nAMD)患者的解剖和功能的疗效。研究评估了来自9个三级视网膜中心的治疗效果并根据作者的实际应用经验探讨了初始方案选择的影响。结果表明无论使用何种药物,抗血管内皮生长因子治疗的负荷剂量都能显著改善nAMD患者的解剖和功能结果,尤其是在早期随访期间。

http://www.ijo.cn/en_publish/2020/1/20200115.pdf



Clinical Research

Ocular bacterial infections at a tertiary eye center in China: a 5-year review of pathogen distribution and antibiotic sensitivity

三级眼科中心眼细菌感染的病原菌分布及药敏5年回顾

Wen Gao, Tian Xia, Hua-Bo Chen, Xiao-Jing Pan, Yu-Sen Huang, Xin Wang, Yan-Ling Dong, Li-Xin Xie

 

The study aims to provide statistical evidence for the use of antibiotics in ophthalmology by assessing the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections. Staphylococcus epidermidis is the predominant isolate in all ocular specimens with bacteria. Gatifloxacin is more suitable for topical prophylactic use than levofloxacin in ophthalmology when necessary. Vancomycin and fusidic acid both have better effects on gram-positive bacteria than gram-negative bacteria. More accurate antibiotic sensitivity analysis results can be obtained when a more detailed bacterial classification and more appropriate statistical methods are performed.

该研究旨在通过对疑似微生物感染的眼部样本中细菌菌株的分布和药敏分析,为眼科抗生素的应用提供统计依据。表皮葡萄球菌是所有眼部细菌样本中的主要菌株,必要时加替沙星比左氧氟沙星更适合用于眼科局部预防性用药,同时万古霉素和夫西地酸对革兰阳性菌的作用优于革兰阴性菌。文章指出,更详细的细菌分类和更合适的统计方法可以获得更准确的抗生素敏感性分析结果。

http://www.ijo.cn/en_publish/2020/1/20200108.pdf

 

Clinical Research

Comparative clinical outcomes of Tecnis toric IOL implantation in femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery

飞秒激光辅助与常规超声乳化Tecnis toric人工晶状体植入术的临床比较

Kai-Ran Lai, Xiao-Bo Zhang, Yin-Hui Yu, Ke Yao

The study aimed to compare the short-term visual outcomes, residual refractive cylinder, and rotation stability after Tecnis toric intraocular lens (IOL) implantation during femtosecond laser-assisted cataract surgery (Femto phaco) and conventional phacoemulsification surgery (Conventional phaco). The results show that the Femto phaco group has significantly more subjects with the residual astigmatism of ≤1 D, but there are no significant differences in rotation stability and visual outcomes as compared with the Conventional phaco group after the application of the Tecnis toric IOL in this cohort.

该研究旨在比较飞秒激光辅助白内障手术(Femto phaco)与常规超声乳化白内障手术(Conventional phaco)植入Tecnis toric人工晶状体后的短期视力、残余散光度数及旋转稳定性。结果表明,Femto phacoTecnis toric人工晶状体术后残余散光≤1 D的患者更多,与Conventional phaco组相比,术后旋转稳定性和视力则无明显差异。

http://www.ijo.cn/en_publish/2020/1/20200107.pdf

 

Clinical Research

Different modes of foveal regeneration after closure of full-thickness macular holes by (re)vitrectomy and autologous platelet concentrate

玻璃体切除联合自体浓缩血小板封闭黄斑全层裂孔后中央凹重建的不同模式

Andreas Bringmann, Claudia Jochmann, Jan Darius Unterlauft, Renate Wiedemann, Matus Rehak, Peter Wiedemann

This study described using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana (re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. The data show that there are different modes of foveal regeneration after closure of macular holes with (re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and retinal pigment epithelial cells.

该文章应用频谱光学相干断层成像技术探讨了玻璃体切除和气体填充术联合自体浓缩血小板注射治疗全层黄斑裂孔后中心凹形态的重建情况,并对不同的解剖结果进行分析。结果表明,玻璃体切除联合浓缩血小板治疗黄斑裂孔术后,中央凹存在不同的重建模式。研究认为正常的中央凹重建是通过Müller细胞介导的组织移动进行,不存在细胞增殖,而不规则重建部分是通过Müller细胞和视网膜色素上皮细胞的增殖进行。

http://www.ijo.cn/en_publish/2020/1/20200106.pdf

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