Basic Research

Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population

汉族人IGF1R(rs1546713)基因多态性与年龄相关性白内障易感性的关系

Yi-Lei Cui, Xiao-Ning Yu, Xin Zhang, Ye-Lei Tang, Xia-Jing Tang, Hao Yang, Xi-Yuan Ping, Jing Wu, Qi-Chuan Yin, Jia-Yue Zhou, Xia-Yan Xu, Xing-Chao Shentu

The insulin-like growth factor-1 receptor (IGF1R) gene is essential for the development of lens. Multiple researches mainly concerned that the IGF1R played a vital role in tumorigenesis, survival and metastasis, but the impact of IGF1R on cataract has not been investigated. The study focus on its relationship with age-related cataract (ARC). In addition, the authors also explored whether IGF1R is involved in the cell proliferation, cell cycle and apoptotic process in lens epithelial cells, which maybe a new mechanism for IGF1R variants to induce cataract. According to the results, our study firstly identified a target SNP related to ARC in IGF1R gene, and provided new clues to fully understand the pathological mechanism of lens opacity with IGF1R variants.

IGF1R基因是晶状体发育的关键。许多研究主要关注IGF1R在肿瘤发生、生存和转移中的重要作用，但IGF1R对白内障的影响尚未研究。该研究主要探讨其与年龄相关性白内障(ARC)的关系。此外，作者还探讨了IGF1R是否参与晶体上皮细胞增殖、细胞周期和凋亡过程，这可能是IGF1R变异诱发白内障的新机制。根据研究结果，该研究首次在IGF1R基因中发现了一个与ARC相关的靶点SNP，为深入了解IGF1R变异体晶状体混浊的病理机制提供了新的线索。

http://www.ijo.cn/en_publish/2020/3/20200302.pdf

Review Article

Cosmetic blepharoplasty and dry eye disease: a review of the incidence, clinical manifestations, mechanisms and prevention

眼睑整形术与干眼症：发病率、临床表现、机制与预防

Si-Yi Zhang, Yan Yan, Fu Yao

This research studied the incidence, clinical manifestations, mechanisms and prevention of dry eye disease caused or worsened by cosmetic blepharoplasty. The results showed dry eye disease can be caused by a variety of iatrogenic interventions, especially ophthalmic surgical procedures. The incidence of dry eye disease after cosmetic blepharoplasty is continually increasing. Thus, it is necessary to focus on how to reduce and prevent the occurrence of postoperative dry eye disease and provide the basis for the selection of operation methods and the rational drug during the perioperative period.

该研究探讨由眼睑整形术引起或加重的干眼症的发生率、临床表现、机制及预防。结果表明，干眼症可由多种医源性干预引起，尤其是眼科手术。干眼病的发病率在眼睑整形术后不断增加。因此，有必要关注如何减少和预防术后干眼症的发生，为围手术期手术方法的选择和合理用药提供依据。

http://www.ijo.cn/en_publish/2020/3/20200318.pdf

Investigation

Identification of an immune-related signature for the prognosis of uveal melanoma
葡萄膜黑色素瘤预后免疫相关标志物的鉴别
Ying-Zi Li, Ying Huang, Xiang-Yang Deng, Chang-Sen Tu
This study aimed construct an immune-related prognostic signature (IPS) that can distinguish and predict prognosis in uveal melanoma (UM). The transcriptome data were extracted from the Cancer Genome Atlas (TCGA) to establish and validate an IPS. Combined with the clinicopathological characteristics of patients, the potential clinical utility of IPS indifferent UM subgroups and the correlation of the IPS with immune cell infiltration and immune checkpoints were analyzed to gain insight into the tumor immune microenvironment. The results confirmed that the prognostic value of IPS in distinct subgroups and its association with the T stage and basal diameter of the tumor, and immune checkpoints containing PD-1, CTLA-4, IDO, and TIGIT were moderately associated with the IPS.
该研究旨在建立一个免疫相关的预后特征（IPS）以区分和预测葡萄膜黑色素瘤（UM）的预后。从癌症和肿瘤基因图谱（TCGA）中提取转录组数据用以建立并验证IPS。结合患者的临床病理特点，分析了IPS不同UM亚群的潜在临床应用价值及IPS与免疫细胞浸润和免疫检验点的关系以了解肿瘤免疫微环境。研究结果证实了IPS在不同亚组中的预后价值，与肿瘤的T分期、基底径有相关性。此外，含有PD-1、CTLA-4，IDO，TIGIT的免疫检验点与IPS有中度相关性。

http://www.ijo.cn/en_publish/2020/3/20200314.pdf

Brief Report

Effect of brimonidine tartrate on basophil activation in glaucoma patients

酒石酸溴莫尼定对青光眼患者嗜碱性粒细胞活化的影响

Eldar Rosenfeld, Dana Barequet, Gilad Rabina, Sheila Langier, Moshe Lazar, Gabi Shemesh, Shimon Kurtz, Shmuel Kivity

This study aims to evaluate the mechanism of which brimonidine tartrate 0.15% causes clinical hypersensitivity. The results of this study do not support the hypothesis that brimonidine induces an immediate allergic reaction. Basophil activation was suppressed by the presence of β-blockers in patients hypersensitive to brimonidine and in healthy individuals. This finding indicates that timolol suppress brimonidine drug reaction by a different mechanism.

该研究旨在探讨0.15%酒石酸溴莫尼定引起临床过敏反应的机制。这项研究的结果不支持溴莫尼定引起速发型超敏反应的假设。β受体阻滞剂的存在抑制了对溴莫尼定过敏患者和健康人嗜碱性粒细胞的活化。这一发现表明，噻吗洛尔通过不同的机制抑制了溴莫尼定的药物反应。

http://www.ijo.cn/en_publish/2020/3/20200321.pdf