Highlighted Articles in Int J Ophthalmol Vol.13 No.3 2020


Basic Research

Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population


Yi-Lei Cui, Xiao-Ning Yu, Xin Zhang, Ye-Lei Tang, Xia-Jing Tang, Hao Yang, Xi-Yuan Ping, Jing Wu, Qi-Chuan Yin, Jia-Yue Zhou, Xia-Yan Xu, Xing-Chao Shentu

The insulin-like growth factor-1 receptor (IGF1R) gene is essential for the development of lens. Multiple researches mainly concerned that the IGF1R played a vital role in tumorigenesis, survival and metastasis, but the impact of IGF1R on cataract has not been investigated. The study focus on its relationship with age-related cataract (ARC). In addition, the authors also explored whether IGF1R is involved in the cell proliferation, cell cycle and apoptotic process in lens epithelial cells, which maybe a new mechanism for IGF1R variants to induce cataract. According to the results, our study firstly identified a target SNP related to ARC in IGF1R gene, and provided new clues to fully understand the pathological mechanism of lens opacity with IGF1R variants.




Review Article

Cosmetic blepharoplasty and dry eye disease: a review of the incidence, clinical manifestations, mechanisms and prevention


Si-Yi Zhang, Yan Yan, Fu Yao

This research studied the incidence, clinical manifestations, mechanisms and prevention of dry eye disease caused or worsened by cosmetic blepharoplasty. The results showed dry eye disease can be caused by a variety of iatrogenic interventions, especially ophthalmic surgical procedures. The incidence of dry eye disease after cosmetic blepharoplasty is continually increasing. Thus, it is necessary to focus on how to reduce and prevent the occurrence of postoperative dry eye disease and provide the basis for the selection of operation methods and the rational drug during the perioperative period.





Identification of an immune-related signature for the prognosis of uveal melanoma
Ying-Zi Li, Ying Huang, Xiang-Yang Deng, Chang-Sen Tu
This study aimed construct an immune-related prognostic signature (IPS) that can distinguish and predict prognosis in uveal melanoma (UM). The transcriptome data were extracted from the Cancer Genome Atlas (TCGA) to establish and validate an IPS. Combined with the clinicopathological characteristics of patients, the potential clinical utility of IPS indifferent UM subgroups and the correlation of the IPS with immune cell infiltration and immune checkpoints were analyzed to gain insight into the tumor immune microenvironment. The results confirmed that the prognostic value of IPS in distinct subgroups and its association with the T stage and basal diameter of the tumor, and immune checkpoints containing PD-1, CTLA-4, IDO, and TIGIT were moderately associated with the IPS.




Brief Report

Effect of brimonidine tartrate on basophil activation in glaucoma patients


Eldar Rosenfeld, Dana Barequet, Gilad Rabina, Sheila Langier, Moshe Lazar, Gabi Shemesh, Shimon Kurtz, Shmuel Kivity

This study aims to evaluate the mechanism of which brimonidine tartrate 0.15% causes clinical hypersensitivity. The results of this study do not support the hypothesis that brimonidine induces an immediate allergic reaction. Basophil activation was suppressed by the presence of β-blockers in patients hypersensitive to brimonidine and in healthy individuals. This finding indicates that timolol suppress brimonidine drug reaction by a different mechanism.





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