BASIC RESEARCH

Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells

Qu-Zhen Deji, Feng Yan, Wang-Dui Zhaba, Ya-Jun Liu, Jie Yin, Zhen-Ping Huang

This study aims to explore the roles of microRNA-let7c (miR-let7c) and transforming growth factor-β2 (TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. Based on previous researches, the authors demonstrated human RPE cells undergoing EMT is a key event in the pathogenesis of epiretinal membrane (ERM). And miR-let7c plays an important role in inhibiting TGF-β2-induced EMT, and this inhibitory effect might be regulated by the NF-κB signaling pathway. These findings could aid in exploring new molecular mechanisms of ERM and in the development of novel strategies for the prevention or treatment of proliferative vitreoretinopathy.

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microRNA-let7c和TGF-β2在视网膜色素上皮细胞间质转分化过程中的相互作用

该研究探讨了视网膜色素上皮细胞的上皮-间质转化（EMT）过程中microRNA-let7c（miR-let7c）和转化生长因子-β2（TGF-β2）及细胞信号转导作用。在以往研究的基础上，作者证明了RPE细胞经历EMT是视网膜前膜（ERM）发病机制中的关键因素。而miR-let7c在抑制TGF-β2诱导的EMT中发挥了重要作用，这种抑制作用可能受NF-κB信号通路的调控。这些发现有助于探索ERM新的分子机制，有助于开发预防或治疗增殖性玻璃体视网膜病变的新方法。

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CLINICAL RESEARCH

Optical coherence tomography angiography of the peripapillary region and macula in normal, primary open-angle glaucoma, pseudoexfoliation glaucoma and ocular hypertension eyes

Helin Ceren Köse, Oya Tekeli

This study evaluated and compared the peripapillary and retinal vasculature changes in primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), ocular hypertension (OHT) and normal eyes using optical coherence tomography angiography (OCTA). The results show OCTA can measure reduced peripapillary and macular VD in eyes with glaucoma and OHT, and these results are correlated to functional and structural glaucomatous alterations. Peripapillary and macular superficial plexus VD is lower in eyes with PXG than in eyes with POAG. Furthermore, the OHT eyes demonstrate impaired macular vasculature in both superficial and deep plexus.

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正常眼、原发性开角型青光眼、假性剥脱性青光眼和高眼压症患者视乳头周围和黄斑区的光学相干断层扫描血管成像

该研究采用光学相干断层扫描血管成像（OCTA）对原发性开角型青光眼、假性剥脱性青光眼、高眼压症患者和正常人视乳头周围血管和视网膜血管的变化进行了评估和比较。结果显示OCTA可以检测到青光眼和高眼压症患者的视乳头周围和黄斑区血管密度的减少，这与功能性和结构性青光眼的改变相关。假性剥脱性青光眼相比原发性开角型青光眼，视乳头周围和黄斑浅丛血管密度较低。此外，高眼压症患者黄斑浅丛和深丛的血管均受损。

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CLINICAL RESEARCH

Analysis of choroidal morphology and comparison of imaging ?ndings of subtypes of polypoidal choroidal vasculopathy: a new classification system

Zi-Yang Liu, Bing Li, Song Xia, You-Xin Chen

This study aims to classify polypoidal choroidal vasculopathy (PCV) into 2 subtypes based on the subfoveal choroidal thickness (SFCT) and to further explore their differences of multi-model imaging characteristics. The retrospective observational case series study shows that the 225 μm subfoveal choroidal thickness is taken as the cutoff point for the following classification of thick/thin choroid groups. Significant different image features between the thick and thin choroid groups are found, which verified the scientificity, both in statistical and ophthalmic perspectives.

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脉络膜形态学分析及息肉状脉络膜血管病亚型影像学的比较：一种新的分类系统

该研究根据中心凹下脉络膜厚度将息肉状脉络膜血管病分为两个亚型，并进一步探讨其在多模型成像特性上的差异。该回顾性的病例观察研究表明，225 μm的中心凹下脉络膜厚度可作为厚/薄脉络膜分组的分界点。厚，薄脉络膜组在图像特征上存在显著差异，并从统计学和眼科角度验证了该方法的科学性。

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