Highlighted Articles in Int J Ophthalmol Vol.13 No.6 2020

 

 

COVID-19 AND OPHTHALMOLOGY

Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital

 

Stephanie S.L. Cheung, Cherie Y.K. Wong, Jason C.K. Chan, Carmen K.M. Chan, N.M. Lam, Hunter K.L. Yuen, Victoria W.Y. Wong, Chi Wai Tsang, Clement C.Y. Tham

 

COVID-19 is a rapidly growing pandemic which poses immense threat to the global population. The transmissibility of the disease poses unique risks to practice in ophthalmology, and it is imperative that all infection control measures be taken to protect both healthcare staff and patients. The authors review international guidelines and recommendations on infection control in ophthalmology, and present the infection control measures they have taken at Hong Kong Eye Hospital. The authors have so far succeeded in maintaining essential ophthalmic services while keeping infection rate of staff members at zero. They therefore believe that the model of infection control is of value to the rest of the international ophthalmic community.

 

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COVID-19期间的眼科:香港眼科医院经验之谈

 

COVID-19是一种迅速蔓延的流行病,对全球人口构成巨大威胁。这种疾病的传播性质给眼科工作带来了特殊的风险,必须采取一切防控感染措施来保护医护人员和患者。作者回顾了眼科感染控制的国际指导方针和建议,并介绍了香港眼科医院的防控措施。截止发稿前,作者及其团队成功地保证了基本的眼科服务,同时使工作人员感染率维持在零。因此,他们认为该防控模式对国际眼科界的其他人员也具有价值。

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CLINICAL RESEARCH

Different damage pattern of retinal nerve fiber layer and ganglion cell-inner plexiform layer between early glaucoma and non-glaucomatous optic neuropathy

 

Hui Xiao, Xing Liu, Ping Lian, Ling-Ling Liao, Yi-Min Zhong

 

This study aims to compare the damage pattern of the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell-inner plexiform layer (mGCIPL) between early glaucomatous and non-glaucomatous optic neuropathy (EGON and NGON). Patients with EGON and identified diagnosis of NGON were enrolled in this study. Age- and refractive error-matched healthy subjects were enrolled as controls. The sectoral pRNFL and mGCIPL thickness obtained by high definition optical coherence tomography were analyzed. The present study demonstrated that the damage pattern of pRNFL and mGCIPL in early glaucoma were different from some types of non-glaucomatous neuropathies, and this characteristic damage pattern is helpful in differentiating early glaucoma from other NGON.

 

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早期青光眼与非青光眼性视神经病变中视网膜神经纤维层和神经节细胞-内丛状层的不同损伤模式

 

该研究旨在比较早期青光眼和非青光眼性视神经病变视盘周围神经纤维层(pRNFL)和黄斑神经节细胞-内丛状层(mGCIPL)的损伤模式。研究纳入了已确诊为早期青光眼(EGON)和非青光眼性视神经病变(NGON)的患者。另有年龄和屈光状态匹配的健康受试者作为对照。对高清晰度光学相干层析成像获得的pRNFLmGCIPL厚度进行分析。其研究结果表明,pRNFLmGCIPL在早期青光眼中的损害模式不同于某些类型的非青光眼性神经病变, 这种特征性损害模式有助于早期青光眼与其他NGON的鉴别。

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CLINICAL RESEARCH

Clinical observations of iridociliary cysts and their changes after implantable collamer lens implantation in myopic patients

 

Qian Chen, Meng-Ying Qi, Xiao-Hua Lei, Qing-Yan Zeng

 

This study observed the characteristics of iridociliary cysts in myopic patients and evaluated the influences on the position and safety of implantable collamer lens (ICL) after surgery. The results showed both the incidence and position of occurrence of iridociliary cysts with myopia group are not significantly different with those of normal group, and the incidence of iridociliary cysts has no obvious correlations with the degree of myopia. Under the adjustment of the surgical design, the cysts seem to have no impact on the ICL position and safety. Some cysts may decrease in size or disappear after ICL implantation.

 

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近视患者ICL植入术后虹膜睫状体囊肿的临床观察及变化

 

该研究评估了ICL术后近视患者虹膜睫状体囊肿的特点,以及对ICL的位置和安全性的影响。结果表明,近视患者虹膜囊肿的发生率和发生位置与正常组无显著差异,虹膜囊肿的发生率与近视程度无明显相关性。在手术设计的调整下,囊肿似乎对ICL的位置和安全性没有影响。ICL植入可能会使部分囊肿缩小或消失。

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REVIEW ARTICLE

Metabolomics and biomarkers in ocular matrix: beyond ocular diseases

 

Yun Luo, Hong-Pei Cui, Yi Liu, Lei Chen

 

Ocular diseases may be caused by multi-factor, and remain huge problems for diagnose and treatment worldwide. Although previous researches had been confirmed that endogenous metabolites in the ocular matrix play a crucial role in the progress of diseases related diseases, the standard protocols and systematic summary about the biomarker researches based on ocular matrix has not been established. The authors reviewed and summarized the pretreatment for ocular matrix, and the biomarkers in ocular matrix associated with ocular diseases and systemic diseases. Expected to provide a new way for diagnosis of ocular diseases even beyond ophthalmopathy for systemic diseases.

 

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眼模型中代谢组学和生物标记物在眼病的研究进展

 

眼部疾病可能是由多种因素引起的,世界范围内眼病的诊断和治疗仍然是一个巨大的问题。尽管以往的研究已经证实了的内源性代谢物在疾病相关疾病的进展中起着至关重要的作用,但基于眼部的生物标志物研究还没有建立起标准的方案和系统的总结。作者对眼模型的预处理,以及眼模型中与眼病和全身性疾病相关的生物标志物进行了回顾性研究和总结,希望能为现阶段眼病甚至系统性疾病的诊断提供新的途径。

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