Highlighted Articles in Int J Ophthalmol Vol.13 No.6 2020




Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital


Stephanie S.L. Cheung, Cherie Y.K. Wong, Jason C.K. Chan, Carmen K.M. Chan, N.M. Lam, Hunter K.L. Yuen, Victoria W.Y. Wong, Chi Wai Tsang, Clement C.Y. Tham


COVID-19 is a rapidly growing pandemic which poses immense threat to the global population. The transmissibility of the disease poses unique risks to practice in ophthalmology, and it is imperative that all infection control measures be taken to protect both healthcare staff and patients. The authors review international guidelines and recommendations on infection control in ophthalmology, and present the infection control measures they have taken at Hong Kong Eye Hospital. The authors have so far succeeded in maintaining essential ophthalmic services while keeping infection rate of staff members at zero. They therefore believe that the model of infection control is of value to the rest of the international ophthalmic community.







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Different damage pattern of retinal nerve fiber layer and ganglion cell-inner plexiform layer between early glaucoma and non-glaucomatous optic neuropathy


Hui Xiao, Xing Liu, Ping Lian, Ling-Ling Liao, Yi-Min Zhong


This study aims to compare the damage pattern of the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell-inner plexiform layer (mGCIPL) between early glaucomatous and non-glaucomatous optic neuropathy (EGON and NGON). Patients with EGON and identified diagnosis of NGON were enrolled in this study. Age- and refractive error-matched healthy subjects were enrolled as controls. The sectoral pRNFL and mGCIPL thickness obtained by high definition optical coherence tomography were analyzed. The present study demonstrated that the damage pattern of pRNFL and mGCIPL in early glaucoma were different from some types of non-glaucomatous neuropathies, and this characteristic damage pattern is helpful in differentiating early glaucoma from other NGON.






该研究旨在比较早期青光眼和非青光眼性视神经病变视盘周围神经纤维层(pRNFL)和黄斑神经节细胞-内丛状层(mGCIPL)的损伤模式。研究纳入了已确诊为早期青光眼(EGON)和非青光眼性视神经病变(NGON)的患者。另有年龄和屈光状态匹配的健康受试者作为对照。对高清晰度光学相干层析成像获得的pRNFLmGCIPL厚度进行分析。其研究结果表明,pRNFLmGCIPL在早期青光眼中的损害模式不同于某些类型的非青光眼性神经病变, 这种特征性损害模式有助于早期青光眼与其他NGON的鉴别。

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Clinical observations of iridociliary cysts and their changes after implantable collamer lens implantation in myopic patients


Qian Chen, Meng-Ying Qi, Xiao-Hua Lei, Qing-Yan Zeng


This study observed the characteristics of iridociliary cysts in myopic patients and evaluated the influences on the position and safety of implantable collamer lens (ICL) after surgery. The results showed both the incidence and position of occurrence of iridociliary cysts with myopia group are not significantly different with those of normal group, and the incidence of iridociliary cysts has no obvious correlations with the degree of myopia. Under the adjustment of the surgical design, the cysts seem to have no impact on the ICL position and safety. Some cysts may decrease in size or disappear after ICL implantation.







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Metabolomics and biomarkers in ocular matrix: beyond ocular diseases


Yun Luo, Hong-Pei Cui, Yi Liu, Lei Chen


Ocular diseases may be caused by multi-factor, and remain huge problems for diagnose and treatment worldwide. Although previous researches had been confirmed that endogenous metabolites in the ocular matrix play a crucial role in the progress of diseases related diseases, the standard protocols and systematic summary about the biomarker researches based on ocular matrix has not been established. The authors reviewed and summarized the pretreatment for ocular matrix, and the biomarkers in ocular matrix associated with ocular diseases and systemic diseases. Expected to provide a new way for diagnosis of ocular diseases even beyond ophthalmopathy for systemic diseases.







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