Highlighted Articles in Int J Ophthalmol Vol.13 No.7 2020 

 

BASIC RESEARCH

Blocking VEGF signaling augments interleukin-8 secretion via MEK/ERK/1/2 axis in human retinal pigment epithelial cells

 

Lin-Bin Zhou, Ye-Qi Zhou, Xin-Yu Zhang

 

This study identified proangiogenic factors engaged in neovascular age-related macular degeneration (AMD) except vascular endothelial growth factor (VEGF) from human retinal pigment epithelial (hRPE) cells and investigate the underlying mechanisms. The results show blockade of VEGF signaling augments IL-8 secretion via MEK/ERK1/2 axis and overactivation of VEGF pathway decreases IL-8 production in hRPE cells. Upregulated IL-8 expression after VEGF signaling inhibition in hRPE cells may be responsible for being incompletely responsive to anti-VEGF remedy in neovascular AMD, and IL-8 may serve as an alternative therapeutic target for neovascular AMD.

 

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人视网膜色素上皮细胞通过MEK/ERK1/2通路阻断VEGF信号增强IL-8分泌

 

该研究确定了人视网膜色素上皮细胞中除VEGF以外涉及新血管性年龄相关性黄斑变性的促血管生成因子,并研究了其潜在机制。结果显示,通过MEK/ERK1/2阻断VEGF信号传导进而增加IL-8分泌,同时过度激活的VEGF可减少人视网膜色素上皮细胞中IL-8产生。抑制VEGF信号通路后,人视网膜色素上皮细胞中IL-8表达上调可能是新生血管性年龄相关黄斑变性中抗血管内皮生长因子治疗弱应答的原因。IL-8可以作为新生血管性年龄相关性黄斑变性的另一替代治疗。

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CLINICAL RESEARCH

Objective optical quality and visual outcomes after the PresbyMAX monocular ablation profile

 

Dan Fu, Jing Zhao, Xing-Tao Zhou

 

Presbyopia is an issue for the elderly population. Owing to decreased accommodation, people with presbyopia have trouble completing work activities, frequent eye fatigue, and impaired optical quality. This also leads to lower quality of life. To date, several presbyopia correction methods have been applied to restore near vision. Approaches have included use of intraocular lens, aperture corneal inlay, and corneal refractive surgeries. The major mechanisms of these surgeries are monovision and multifocal design. The purpose of the study was to assess objective visual quality after PresbyMAX monovision ablation. Hope to contribute to the body of evidence regarding surgical presbyopia correction. The conclusion shows that the PresbyMAX monocular mode is safe and effective for presbyopia correction. It has little effect on optical quality, though short-term degraded optical quality occurred mainly in the bi-aspheric ablated eyes.

 

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PresbyMAX单眼切削术后客观视觉质量和视觉效果

 

老视是老年人常见的视力问题。由于调节能力减弱,老视不但影响工作活动,经常眼疲劳,视觉质量下降,也导致生活质量下降。迄今为止,已有数种老视矫正方法用于恢复近视力,包括植入人工晶体,小孔角膜嵌入环和角膜屈光手术。这些手术机制主要包括单眼视和多焦点设计。该研究的目的是评估PresbyMAX单眼视切削模式的客观视觉质量,希望对老视手术矫正提供相关依据。结论显示PresbyMAX单眼视模式是一种安全有效的老视矫正方法。虽然短期内视觉质量下降主要发生在双非球面切削眼,但对视觉质量影响不大。

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INVESTIGATION

Knowledge, attitudes and practices related to seeking medical eyecare services by adults with moderate-to-severe visual impairment in rural Yueqing, Wenzhou, China: a cross-sectional survey

 

Lin-Shan Li, Zheng-Yan Ge, Lynne Lohfeld, Kun Zhou, Wei-He Zhou, Le-Le Cui, Jia Qu, Yuan-Bo Liang

 

This study aims to evaluate the knowledge, attitudes, and practices regarding eye-care seeking practices of visually impaired adults in a rural area Yueqing, and explore factors influencing their behavior. A stratified sampling method was used to select 48 villages (2400 people) in Yueqing and a self-designed questionnaire was conducted. The results suggest that intervention is required to increase public knowledge about seeking medical eye care among people with moderate-to-severe visual impairment, especially for the elderly and poorly education. It’s important to focus on increasing public knowledge of eye diseases as well as advice people with visual impairment to have regular eye exams.

 

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中国温州乐清农村中重度视力障碍成年人寻求眼科医疗服务的相关知识、态度和做法:横断面调查

 

该研究旨在了解乐清农村地区成人视力障碍者对眼保健的认知、态度和做法,并探讨影响视障者眼保健行为的因素。采用分层抽样的方法,对乐清市48个农村(2400人)进行了问卷调查。结果表明,在中重度视力障碍人群中,尤其是老年人和文化程度较低的人群中,需要进行干预,以提高公众对眼科医疗的认识。提高公众对眼部疾病的认识,并建议视力受损的人定期进行眼部检查具有重要意义。

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REVIEW ARTICLE

Effect of rigid gas permeable contact lens on keratoconus progression: a review

 

Xiao-Han Zhang, Xuan Li

 

The study aimed to discuss the related contents of rigid gas permeable (RGP). RGP is an important non-surgical treatment for keratoconus and has been widely used in recent years. At the same time, its side effects in patients with keratoconus are also concerned. The authors summarized the therapeutic effects and side effects of RGP, which is helpful for clinicians to comprehensively evaluate its efficacy and adverse effects, and then chose the best treatment measures to avoid unnecessary damage caused by ignoring its side effects. And it is also beneficial to the improvement of keratoconus treatment and the optimization of RGP.

 

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透气性硬性角膜接触镜对圆锥角膜病变进展的影响

 

该研究旨在探讨硬性透气性角膜接触镜(RGP)的应用。RGP是一种重要的非手术治疗圆锥角膜的方法,近年来得到了广泛的应用。同时,其对圆锥角膜患者的副作用也备受关注。该文作者总结了RGP的治疗效果和副作用,有利于临床医生全面评估其疗效和不良反应,进而选择最佳的治疗措施,避免因忽视其副作用而造成不必要的损害,而且有利于提高圆锥角膜治疗水平和RGP的优化。

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