Highlighted Articles in Int J Ophthalmol Vol.13 No.7 2020 



Blocking VEGF signaling augments interleukin-8 secretion via MEK/ERK/1/2 axis in human retinal pigment epithelial cells


Lin-Bin Zhou, Ye-Qi Zhou, Xin-Yu Zhang


This study identified proangiogenic factors engaged in neovascular age-related macular degeneration (AMD) except vascular endothelial growth factor (VEGF) from human retinal pigment epithelial (hRPE) cells and investigate the underlying mechanisms. The results show blockade of VEGF signaling augments IL-8 secretion via MEK/ERK1/2 axis and overactivation of VEGF pathway decreases IL-8 production in hRPE cells. Upregulated IL-8 expression after VEGF signaling inhibition in hRPE cells may be responsible for being incompletely responsive to anti-VEGF remedy in neovascular AMD, and IL-8 may serve as an alternative therapeutic target for neovascular AMD.






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Objective optical quality and visual outcomes after the PresbyMAX monocular ablation profile


Dan Fu, Jing Zhao, Xing-Tao Zhou


Presbyopia is an issue for the elderly population. Owing to decreased accommodation, people with presbyopia have trouble completing work activities, frequent eye fatigue, and impaired optical quality. This also leads to lower quality of life. To date, several presbyopia correction methods have been applied to restore near vision. Approaches have included use of intraocular lens, aperture corneal inlay, and corneal refractive surgeries. The major mechanisms of these surgeries are monovision and multifocal design. The purpose of the study was to assess objective visual quality after PresbyMAX monovision ablation. Hope to contribute to the body of evidence regarding surgical presbyopia correction. The conclusion shows that the PresbyMAX monocular mode is safe and effective for presbyopia correction. It has little effect on optical quality, though short-term degraded optical quality occurred mainly in the bi-aspheric ablated eyes.






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Knowledge, attitudes and practices related to seeking medical eyecare services by adults with moderate-to-severe visual impairment in rural Yueqing, Wenzhou, China: a cross-sectional survey


Lin-Shan Li, Zheng-Yan Ge, Lynne Lohfeld, Kun Zhou, Wei-He Zhou, Le-Le Cui, Jia Qu, Yuan-Bo Liang


This study aims to evaluate the knowledge, attitudes, and practices regarding eye-care seeking practices of visually impaired adults in a rural area Yueqing, and explore factors influencing their behavior. A stratified sampling method was used to select 48 villages (2400 people) in Yueqing and a self-designed questionnaire was conducted. The results suggest that intervention is required to increase public knowledge about seeking medical eye care among people with moderate-to-severe visual impairment, especially for the elderly and poorly education. It’s important to focus on increasing public knowledge of eye diseases as well as advice people with visual impairment to have regular eye exams.






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Effect of rigid gas permeable contact lens on keratoconus progression: a review


Xiao-Han Zhang, Xuan Li


The study aimed to discuss the related contents of rigid gas permeable (RGP). RGP is an important non-surgical treatment for keratoconus and has been widely used in recent years. At the same time, its side effects in patients with keratoconus are also concerned. The authors summarized the therapeutic effects and side effects of RGP, which is helpful for clinicians to comprehensively evaluate its efficacy and adverse effects, and then chose the best treatment measures to avoid unnecessary damage caused by ignoring its side effects. And it is also beneficial to the improvement of keratoconus treatment and the optimization of RGP.






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