Highlight Articles in Int J Ophthalmol Vol.13 No.8 2020




Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model


Takeshi Arima, Tsutomu Igarashi, Masaaki Uchiyama, Maika Kobayashi, Ikuroh Ohsawa, Akira Shimizu, Hiroshi Takahashi


This study aims to investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn. The authors found that numbers of both inflammatory infiltrating and vascular endothelial cells were significantly reduced in the corneas of rats treated with an instillation of H2-dissolved saline both before and after corneal injury. Furthermore, H2 treatment markedly increased both the cytoplasmic SOD1 levels and activity in corneal epithelial cells, compared to saline treatment. The findings suggest that H2 treatment suppresses inflammation and neovascularization in the injured cornea and indirectly suppresses an oxidative insult to the cornea by upregulating both the level and activity of SOD1.






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Measurements of the parapapillary atrophy area and other fundus morphological features in high myopia with or without posterior staphyloma and myopic traction maculopathy


Xiao-Xiao Guo, Xi Chen, Shan-Shan Li, Min Li, Xiu-Fen Yang, Lu Zhao, Ran You, Yan-Ling Wang


High myopia is a major cause of visual impairment. Myopic traction maculopathy (MTM) is a high myopia-related complication caused by several mechanisms, with traction as a common pathway. Usually, axial length (AL), age and posterior staphyloma (PS) are main risk factors for the progression of fundus diseases in high myopia, but mechanisms for the development of MTM still remain unclear.

The study examined high myopia patients at different stages of progression based on PS and MTM. According to morphological changes, the authors analyzed the relationship between anatomical features and different stages of high myopia. The results show that, the characteristics of the gamma and delta zones changed inconsistently in different stages of high myopia patients. These changes might be associated with anatomical changes caused by local traction. Factors such as PS, AL and age played an important role. These findings might provide a hint about the pathogenesis of traction in high myopia patients.






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Comparative 2-year outcomes of conventional and accelerated corneal collagen crosslinking in progressive keratoconus


Ömür Ö. Uçakhan, Ya?mur Seda Ye?ilta?


This study compared the safety and efficacy of conventional versus accelerated (9 mW/cm2) corneal collagen crosslinking (CXL) in progressive keratoconus at the 2-year follow-up. Uncorrected distance visual acuity, best spectacle-corrected distance visual acuity, manifest refraction, slit-lamp biomicroscopy findings, corneal tomography, and in vivo confocal microscopy were recorded at baseline, and at 1, 3, and 6mo, and 1 and 2y after receiving conventional CXL (CCXL) or accelerated CXL (ACXL) treatment. The results showed, ACXL is less effective in halting the progression of keratoconus at a 2-year follow-up compared to CCXL.





该研究通过2年随访比较了进展性圆锥角膜常规和加速(9 mW/cm2)角膜胶原交联的安全性以及有效性。随访术后136月以及12年的裸眼视力、最佳矫正视力、显性验光、裂隙灯检查、角膜地形图和共聚焦显微镜检查结果显示,与常规角膜胶原交联术相比,加速角膜胶原交联术在终止圆锥角膜进展的2年随访中效果较差。

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Ocular injury resulting in eye removal at a large tertiary care center in China


Han Wu, Jing-Yi Wang, Xin-Cao Zhong, Xin Shi, Yi-Hua Wu, Juan Ye


This study aims to investigate the risk factors for eye removal following ocular trauma at a major ophthalmology department in China. The retrospective study included 1675 removal eyes from 1674 patients over the 20-year period. The results show that work-related injuries are the important cause of severe ocular injury resulting in eye removal. In addition, men and undereducated patients were more likely to undergo eye removal surgery following ocular trauma, and preventive efforts based on the analysis of these risk factors may reduce the incidence of ocular trauma. The data suggest that appropriate use of protective eyewear, better education, and decrement of environmental risks and high-risk activities could reduce the morbidity associated with eye injuries.






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