Highlight Articles in Int J Ophthalmol Vol.13 No.10 2020 

 

BASIC RESEARCH

Anti-proliferation and apoptosis-inducing effects of sodium aescinate on retinoblastoma Y79 cells

 

Lei Li, Bing Xu, Cai-Rui Li, Miao-Miao Zhang, Sheng-Jun Wu, Wen-Jun Dang, Jing-Chen Liu, Shu-Guang Sun, Wei Zhao

 

This study aims to investigate the anti-proliferation and apoptosis-inducing effects of sodium aescinate (SA) on retinoblastoma Y79 cells and its mechanism. The results revealed that SA inhibits the proliferation and promotes the apoptosis of Y79 cells. SA down-regulates the expression of CDK1 and CyclinB1, and reduces mature promoting factor production, causing the cell cycle to stop in the G2/M phase. Furthermore, SA induces apoptosis of Y79 cells through the mitochondrial apoptotic pathway mediated by caspase-9 and through the death-receptor pathway mediated by caspase-8. These results lay a solid foundation for the development of SA as an effective chemotherapeutic drug for the treatment of retinoblastoma.

 

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七叶皂苷钠对视网膜母细胞瘤Y79细胞增殖和凋亡的诱导作用

 

该研究旨在探讨七叶皂苷钠对视网膜母细胞瘤Y79细胞增殖和凋亡的诱导作用及其机制。研究结果表明七叶皂苷钠能抑制Y79细胞增殖,促进细胞凋亡。七叶皂苷钠能够下调CDK1CyclinB1的表达,减少促成熟因子的产生,使细胞周期停止在G2/M期。此外,七叶皂苷钠通过caspase-9介导的线粒体凋亡途径和caspase-8介导的死亡受体途径诱导Y79细胞凋亡。这些结果为七叶皂苷钠作为治疗视网膜母细胞瘤的有效化疗药物奠定了坚实的基础。

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CLINICAL RESEARCH

Shifting hierarchy of the conjunctival florae in the patients employed a long-time topical fluoroquinolone

 

Xue-Hui Zhang, Ying Tian, Yi-Yi Wen, Shuang-Yong Wang

 

The authors observed the shifting hierarchy of the conjunctival florae in the patients who employed a long-time topical fluoroquinolone and characterize their consequent variations of the antibiotic sensitivity and virulence, which would help clinicians to understand the conjunctival flora-associated opportunistic infection and modify the clinical strategies of the prophylaxis of the conjunctival flora-associated infection. In conclusion, a long-time topical fluoroquinolone leads to a shifting hierarchy of the conjunctival florae, accompanied by the consequent variations of the antibiotic sensitivity and virulence.

 

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长期局部使用氟喹诺酮类药物的患者结膜菌群层次的变化

 

作者观察了长期局部使用氟喹诺酮类药物的患者结膜菌群层次的变化,以及相应的抗生素敏感性和毒性的变化特征,这将有助于临床医生了解结膜菌群相关的机会性感染并改进临床结膜菌群相关感染的预防策略。结论显示,长期局部使用氟喹诺酮类药物会导致结膜菌群层次的改变,并伴随着抗生素敏感性和毒性的变化。

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CLINICAL RESEARCH

Comparison of intravitreal anti-vascular endothelial growth factor agents and treatment results in Irvine-Gass syndrome

 

Fahrettin Akay, Mehmed U?ur I??k, Berkay Akmaz, Yusuf Ziya Güven

 

Irvine-Gass syndrome (IGS) is the most common cause of unexpected visual loss by causing CME after cataract surgery. The study aimed to compare the efficacy of bevacizumab, ranibizumab, and aflibercept in naive pseudophakic cystoid macular edema (CME) patients and to compare the OCT results of these patients with fellow healthy eyes’ that underwent uncomplicated cataract surgery. The results indicate that all three anti-VEGF agents seem to be effective in CME but bevacizumab appears to be slightly more cost-effective than the other two alternatives.

 

对照译文

玻璃体内注射抗血管内皮生长因子治疗Irvine-Gass综合征的疗效比较

 

Irvine-Gass综合征(IGS)是白内障术后引起黄斑囊样水肿(CME)的最常见原因。该研究旨在比较贝伐单抗、雷尼珠单抗和阿柏西普治疗CME的疗效,并将患眼与接受常规白内障手术的对侧健康眼的OCT结果进行比较。研究结果发现所有三种抗血管内皮生长因子的药物对于治疗CME均有效,但贝伐单抗比其他两种药物更具成本效益。

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CLINICAL RESEARCH

Altered amplitude of low-frequency fluctuations and default mode network connectivity in high myopia: a resting-state fMRI study

 

Xue-Wei Zhang, Rong-Ping Dai, Gang-Wei Cheng, Wei-Hong Zhang, Qin Long

 

This study analyzed changes in amplitude of low-frequency fluctuations (ALFFs) and default mode network (DMN) connectivity in the brain, using resting-state functional magnetic resonance imaging (rs-fMRI), in high myopia (HM) patients. ALFFs in left inferior temporal gyrus (ITG), bilateral rectus gyrus (REC), bilateral middle temporal gyrus (MTG), left superior temporal gyrus (STG), and left angular gyrus (ANG) were detected in HM group compared with non-HM group significantly increased. HM group showed increased functional connectivity (FC) in the posterior cingulate gyrus (PCC)/precuneus (preCUN) and decreased FC in the left medial prefrontal cortex (mPFG) within DMN compared with non-HM group. HM patients show different ALFFs and DMNs compared with non-HM subjects, which may imply the cognitive alterations related to HM.

 

对照译文

高度近视患者低频波幅和默认模式网络连接的改变: 静息态功能性磁共振成像研究

 

该研究利用静息状态功能性磁共振成像技术分析了高度近视患者大脑中低频波振幅和默认模式网络连接的变化。结果显示高度近视组左颞下回,双侧直肌回,双侧颞中回,左颞上回和左角回的低频波波幅明显高于非高度近视组。与非高度近视组相比,高度近视组默认模式网络中扣带后回/楔前叶的功能性连接增加,左内侧前额叶皮层的功能性连接降低。与非高度近视患者相比,高度近视患者表现出不同的低频波动和默认模式网络,这可能暗示与高度近视相关的认知改变。

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