BASIC RESEARCH

Protective effects of riboflavin-UVA-mediated posterior sclera collagen cross-linking in a guinea pig model of form-deprived myopia

Ding Han, Mei-Nan He, Ying Zhu, Yan Zhang, Rui-Hua Wei

This study aims to evaluate the effect of posterior sclera collagen cross-linking induced by riboflavin-ultraviolet A (UVA) on form-deprived myopia in guinea pigs. Twenty-five pigmented guinea pigs of 3-week-old were randomly assigned into 4 groups that included normal control (n=7), form-deprived (n=7), normal with riboflavin-UVA cross-linking (n=5) and form-deprived with cross-linking (n=6). An evaluation of the biomechanical parameters demonstrated an increase in the biomechanical stiffness of cross-linked sclera as compared to the uncross-linked sclera. The biomechanical parameters of sclera are improved by treatment with riboflavin-UVA collagen cross-linking. Cross-linking enhances sclera’s anti-traction and anti-hydrolysis capabilities so that it would have sufficient resistance to intraocular pressure to maintain the size and shape of the ocular globe, and finally to slow down the myopia progression.

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核黄素UVA介导后巩膜胶原交联对豚鼠形觉剥夺性近视模型的保护作用

该研究旨在探讨核黄素紫外线A诱导后巩膜胶原交联对豚鼠形觉剥夺性近视的影响。将25只3周龄豚鼠随机分为正常对照组（n=7）、形觉剥夺组（n=7）、核黄素紫外线A交联正常组（n=5）和形觉剥夺交联组（n=6）。生物力学参数评估显示，与未交联巩膜相比，交联巩膜的生物力学硬度增加。核黄素紫外线A胶原交联可以改善巩膜的生物力学参数。交联增强了巩膜的抗牵拉和抗水解能力，使其对眼压有足够的抵抗力，维持了眼球的大小和形状，最终减缓近视的进展。

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CLINICAL RESEARCH

Visual performance of four types of diffractive multifocal intraocular lenses and a review of articles

Farideh Doroodgar, Feizollah Niazi, Azad Sanginabadi, Farid Karimian, Sana Niazi, Cyrus Alinia, Mohammad Ali Javadi

Multifocal intraocular lenses (IOLs) have been reported as a substitute for improving near vision and quality of life for many patients. The aim of the study is to compare the clinical outcomes of a variety of multifocal intraocular lenses (MIOLs) in patients diagnosed with presbyopia or cataracts. All four groups of the multifocal lenses were satisfying in terms of distance and near vision. Also, the group of trifocal lenses led to satisfactory outcomes in intermediate vision, without degradation in quality of vision.

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四种衍射多焦人工晶状体的视觉性能与文献综述

多焦点人工晶状体（IOL）已被报道为许多患者改善近视力和生活质量的替代品。该研究的目的是比较各种多焦点人工晶状体（MIOLs）在老视或白内障患者中的临床效果。四组多焦镜片的远视力和近视力均令人满意。此外，三焦距镜片组在中间视力方面取得了令人满意的结果，视觉质量没有下降。

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CLINICAL RESEARCH

Comparing posture induced intraocular pressure variations in normal subjects and glaucoma patients

Onyekachi Jane Ireka, Chimdia E Ogbonnaya, Obinna C Arinze, Nneka Ogbu, Chimdi M Chuka-Okosa

Glaucoma is the common cause of irreversible blindness. Intraocular pressure (IOP) is the only modifiable risk factor. Posture-induced IOP variation is a risk factor for progression. Some studies have reported that posture induced IOP changes are higher in glaucoma than non-glaucoma while other authors reported no difference. A case-controlled age matched study was conducted in 55 successive newly diagnosed primary open-angle glaucoma (POAG) and 56 non-glaucomatous patients. Greater variations in posture induced IOP occurred in POAG patients than non-glaucomatous. The posture induced IOP variation is lowest in the sitting position and highest in the supine flat position. Evaluation of posture induced IOP changes may be an important tool in the management of glaucoma.

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正常人与青光眼患者体位性眼压变化的比较

青光眼是不可逆性失明的常见原因。眼压是唯一可改变的危险因素。体位引起的眼压变化是进展的危险因素。一些研究报道，青光眼患者中，体位引起的眼压变化高于非青光眼患者，亦有研究者报道没有差异。作者对55例新诊断的原发性开角型青光眼（POAG）和56例年龄匹配非青光眼患者进行病例对照研究，结果发现POAG患者体位诱导的眼压变化大于非青光眼患者。坐位引起的眼压变化最小，仰卧位引起的眼压变化最大。体位性眼压变化的评估可能是治疗青光眼的一个重要参考。

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REVIEW ARTICLE

Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment

Xian-Ning Liu, Sheng-Li Mi, Yun Chen, Yao Wang

The study aimed to review the localization and biological characteristics of corneal stroma-derived mesenchymal stem cells (CS-MSCs), the use of CS-MSCs to reconstruct a tissue-engineered active biocornea, and the repair of the limbal and matrix microenvironment by CS-MSCs, and discuss the application prospects. CS-MSCs are stem cells with self-renewal and multidirectional differentiation potential. A large amount of data confirmed that CS-MSCs can be induced to differentiate into functional keratocytes in vitro, which is the motive force for maintaining corneal transparency and producing a normal corneal stroma. CS-MSCs are also an important component of the limbal microenvironment. Furthermore, they are of great significance in the reconstruction of ocular surface tissue and tissue engineering for active biocornea construction.

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角膜基质间充质干细胞：重建具有生物活性的角膜并修复角膜缘和基质微环境

该研究旨在回顾角膜基质间充质干细胞（CS-MSCs）的定位、生物学特性，利用CS-MSCs构建组织工程活性生物角膜和修复角膜缘和基质微环境等方面的研究进展，并探讨其应用前景。CS-MSCs是具有自我更新和多向分化潜能的干细胞。大量资料证实，CS-MSCs在体外可诱导分化为功能性角膜细胞，这是维持角膜透明性和产生正常角膜基质的原动力。CS-MSCs也是角膜缘微环境的重要组成部分，在眼表组织重建和生物活性组织工程角膜构建中具有重要意义。

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