Highlight Articles in Int J Ophthalmol Vol.14 No.4 2021
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Highlight Articles in Int J Ophthalmol Vol.14 No.4 2021

  

BASIC RESEARCH

Effect of Andrographis paniculata polysaccharide on human retinoblastoma Y79 cell proliferation and apoptosis

Bing Xu, Lei Li, Wei Zhang, Yue Li, Mao-Ren Wang, Jing-Chen Liu, Kai-Ye Dong, Ido Didi Fabian, Dong Qiu, Cai-Rui Li, Yi-Min Xiang

 

This study aims to explore the effect of the Andrographis paniculata (A. paniculata) polysaccharide on the proliferation and apoptosis of human retinoblastoma (RB) Y79 cells and its mechanism. The refined A. paniculata polysaccharide was obtained using techniques such as water extraction, ethanol precipitation, and decompression concentration. Cell proliferation assay, flow cytometry, real-time qunatitative polymerase chain reaction and Western blot were used. The study results show the Andrographis paniculata polysaccharide could inhibit the proliferation and induce apoptosis of Y79 cells. Its possible mechanism is via the upregulation of caspase-3, caspase-8, and caspase-9 expression in the cell apoptotic signaling pathway and the downregulation of CDK1 and cyclinB1 expression in the cell cycle signaling pathway.

 

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穿心莲多糖对人视网膜母细胞瘤Y79细胞增殖和凋亡的影响

 

该研究旨在探讨穿心莲多糖对人视网膜母细胞瘤Y79细胞增殖和凋亡的影响及其机制。研究者采用水提醇沉法获得精制穿心莲多糖,并应用细胞增殖试验、流式细胞术、实时定量聚合酶链反应和Western blot进行研究。结果表明,穿心莲多糖能抑制Y79细胞增殖,诱导其凋亡。其机制可能是通过上调细胞凋亡信号通路中caspase-3caspase-8caspase-9的表达及下调细胞周期信号通路中CDK1cyclinB1的表达。

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CLINICAL RESEARCH

Trabeculectomy with Ologen implant versus perfluoropropane gas bubble for open angle glaucoma in pseudophakic eyes

Ahmed S Elwehidy, Tharwat Mokbel, Hossam Youssef Abouelkheir, Waleed Abou Samra, Faried M wagdy, Amr Mohammed Elsayed Abdelkader

 

The study aimed to evaluate the safety and efficacy of augmented trabeculotomy with ologen versus perfluoropropane in management of pseudophakic glaucoma. The results indicated that augmentation of trabeculectomy with either Ologen implant or perfluoropropane gas bubble were associated with strict long term intraocular tension control and evident safety in medically-uncontrolled pseudophakic eyes with open angle glaucoma.

 

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比较小梁切除术联合Ologen植入或全氟丙烷气泡治疗开角型青光眼合并人工晶状体眼

 

该研究旨在评估小梁切除术联合Ologen植入或全氟丙烷治疗开角型青光眼合并人工晶状体眼的有效性和安全性。结果表明,对于药物控制不佳的人工晶状体眼合并开角型青光眼,行加强小梁切除术联合Ologen植入或全氟丙烷气泡均可长期严格控制眼压,具有明显的安全性。

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REVIEW ARTICLE

Commentary review on peripapillary morphological characteristics in high myopia eyes with glaucoma: diagnostic challenges and strategies

Yan-Hui Chen, Rui-Hua Wei, Yan-Nian Hui

 

The incidences of open-angle glaucoma (OAG) and high myopia are increasing concomitantly. Considering the aging population and concurrent rapid increase in the number of individuals with myopia, the risk of visual defects caused by highly myopic OAG is likely to increase dramatically over the next few decades. However, precise screening and diagnosis of OAG is challenging because of the tilt and rotation of the optic disc, as well as extensive β-zone parapapillary atrophy in highly myopic eyes. Recent advances in optical coherence tomography (OCT) and OCT angiography (OCTA) technologies imply that both modalities are promising tools for the detection of highly myopic OAG. Notably, the diagnosis of OAG remains to be determined with the longitudinal changes of functional damages (e.g. visual field defect, visual electrophysiological changes). The authors describe some aspects of microvascular and microstructural pathology in patients with highly myopic OAG and proposes a framework for the development of novel diagnostic and therapeutic strategies.

 

对照译文

高度近视合并青光眼视盘周围形态特征:诊断挑战和策略

 

开角型青光眼(OAG)和高度近视的发病率呈上升趋势。考虑到人口老龄化和近视人数的迅速增加,高度近视OAG导致视觉缺陷的风险在未来几十年内可能会急剧增加。然而,由于高度近视视盘的倾斜和旋转,以及广泛的β区乳头旁萎缩,精确筛查和诊断OAG具有挑战性。光学相干断层扫描(OCT)和OCT血管造影(OCTA)技术的最新进展表明,这两种方法是检测高度近视OAG理想工具。值得注意的是,OAG的诊断仍需根据功能损害的纵向变化(如视野缺损、视电生理改变)来确定。该文介绍了高度近视性OAG患者的微血管和显微结构病理改变,并提出了新的诊断和治疗策略。

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REVIEW ARTICLE

Review on current concepts of myopia and its control strategies

Raju Kaiti, Ranjila Shyangbo, Indra Prasad Sharma, Manish Dahal

 

Myopia poses a significant burden on the healthcare system, economy and quality of life. It is an emerging global public health challenge and requires interventions to delay or stop onset and progression. With changing times and evidence, the concepts of myopia are changing along with the treatment and control strategies. Behavioural modifications including increased outdoors time and reduced near work, optical and pharmaceutical management options are reviewed.

 

对照译文

近视的概念及其控制策略研究进展

 

现今,近视对医疗系统、社会经济和人们的生活质量构成巨大负担,已是一个全球性公共卫生挑战,需要采取干预措施来延缓或阻止其发病和进展。随着时代变迁和循证的变化,人们对近视的认识也随治疗方法和控制策略的改变而改变。该文对于日常行为的改变包括增加户外时间和减少近距离工作,视觉和药物管理的选择等进行了评论。

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Published date:2021-03-29Click:

Editors-in-Chief: Yan-Nian Hui and Peter Wiedemann

Established in April, 2008

ISSN 2222-3959 print

ISSN 2227-4898 online

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