BASIC RESEARCH

Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression

Pu Zhang, Yan-Dan Zhou, Yao Tan, Ling Gao

In order to study the mechanism of piperine in protecting the diabetic retina, in our knowledge, the authors reported for the first time in using piperine for treating early diabetic mice in vitro and in vivo. And the results showed that piperine would be served as a novel and multi-target drug in curing diabetic retinopathy. Piperine may exert protective effects on the retina of mice with diabetes via regulating the pro-antiangiogenic homeostasis composed of HIF-1/VEGFA and PEDF.

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胡椒碱通过抑制HIF-1/VEGFA通路及促进PEDF表达对链脲佐菌素诱导的糖尿病小鼠视网膜的保护作用

为了研究胡椒碱对糖尿病视网膜的保护作用机制，作者首次报道了胡椒碱治疗早期糖尿病小鼠的体内外研究。结果表明，胡椒碱有望成为治疗糖尿病视网膜病变的新型多靶点药物。胡椒碱可能通过调节HIF-1/VEGFA和PEDF组成的促抗血管生成稳态对糖尿病小鼠视网膜产生保护作用。

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CLINICAL RESEARCH

Iris manipulation during phacoemulsification: intraoperative and postoperative complications

Eric R. Williams, Jennifer L. Patnaik, D. Claire Miller, Anne M. Lynch, Richard S. Davidson, Malik Y. Kahook, Leonard K. Seibold

In this study the researchers quantified the intraoperative and postoperative complications in complex phacoemulsification cataract extraction (Phaco) with iris manipulation compared to non-complex or complex phaco without iris manipulation. The medical records of 5772 eyes were reviewed (500 complex without iris manipulation, 367 with iris manipulation). The number of any intraoperative complication in the complex with iris manipulation and complex without iris manipulation groups was 4.1% and 5.2%, respectively, compared to 0.8% in the non-complex group. The postoperative inflammation in Phaco with iris manipulation was 2.3 times compared to non-complex Phaco. However, only complex cases with iris manipulation led to increase rates of postoperative inflammation and IOP spikes >10 mm Hg.

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白内障超声乳化术中虹膜处理的术中及术后并发症

在该研究中，研究人员对采用虹膜处理的复杂超声乳化白内障摘除术（Phaco）的术中和术后并发症进行了量化，并与不采用虹膜处理的单纯或复杂Phaco进行比较。研究人员共回顾性分析了5772眼的临床资料（500眼无虹膜处理，367眼有虹膜处理）。合并虹膜处理和无虹膜处理的复杂Phaco术中并发症分别为4.1%和5.2%，单纯Phaco术中并发症仅为0.8%。采用虹膜处理Phaco术后炎症发生率为单纯Phaco的2.3倍，然而，只有复杂Phaco合并虹膜处理导致术后炎症和眼压峰值>10 mm Hg的发生率增加。

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CLINICAL RESEARCH

Transepithelial photorefractive keratectomy for myopia: effect of age and keratometric values

Amanda Nur Shinta Pertiwi, Indra Tri Mahayana, Agus Supartoto, Wasisdi Goenawan, Suhardjo

The study aimed to investigate demographic and preoperative factors increasing the risk of ametropia following transepithelial photorefractive keratectomy (transPRK) in myopia and myopic astigmatism. The authors analyzed the relationship between the outcome of transPRK (ametropia and emmetropia) with the demographic and preoperative factors of the subjects and found age and certain cut-offs of keratometric values as the predictor factors of transPRK outcome. These predictors factors of transPRK could be used as the materials for patients’ education prior signing up for corneal laser ablative surgeries.

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经上皮准分子激光屈光性角膜切削术治疗近视：年龄和角膜曲率的影响

该研究旨在探讨人口学和术前因素增加近视和近视散光患者行经上皮屈光性角膜切削术（transPRK）后屈光不正的风险。作者分析了transPRK（屈光不正和正视）的结果与患者的人口学和术前因素的关系，发现年龄和某些角膜曲率的临界值是transPRK结果的预测因素。这些transPRK的预测因子可作为患者接受角膜激光手术前的参考资料。

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REVIEW ARTICLE

Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration

Li-Hui Meng, You-Xin Chen

This review aims to present the crucial processes that occur in age-related macular degeneration at the level of Bruch’s membrane, with special consideration of the lipid accumulation and protein modifications. Besides, some therapies targeted at these molecules and the construction of BM in tissue engineering of retinal pigment epithelium cells transplantation were listed. Hopefully, this review may provide a reference for researchers engaged in pathogenesis or management on AMD.

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年龄相关性黄斑变性中Bruch膜的脂类沉积和蛋白修饰

该综述旨在介绍年龄相关性黄斑变性Bruch膜发生的关键过程，特别是脂类沉积和蛋白修饰。此外，还介绍了针对这些分子的一些治疗方法以及在视网膜色素上皮细胞移植组织工程中Bruch膜的构建。希望本文能为从事年龄相关性黄斑变性发病机制或治疗的研究者提供参考。

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