BASIC RESEARCH

Retinal neovascularization induced by mutant Vldlr gene inhibited in an inherited retinitis pigmentosa mouse model: an in-vivo study

Wei-Ming Yan, Pan Long, Mei-Zhu Chen, Dong-Yu Wei, Jian-Cong Wang, Zuo-Ming Zhang, Lei Zhang, Tao Chen

The study aimed to explore whether the retinal neovascularization (NV) in a genetic mutant mice model could be ameliorated in an inherited retinitis pigmentosa (RP) mouse, which would help to elucidate the possible mechanism and prevention of retinal NV diseases in clinic. The results revealed that the development of retinal NV caused by mutant Vldlr gene is inhibited in an inherited RP mouse model. The underlying mechanism for these phenomena may be ascribed to the down-regulation of the expression levels of vascular endothelial growth factor by a hyperoxic state of the retina. These results may help provide the basis for the intervention of retinal NV diseases in clinic.

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遗传性视网膜色素变性小鼠抑制Vldlr基因突变诱导的视网膜新生血管形成的体内研究

该研究探讨遗传性视网膜色素变性小鼠是否可以改善视网膜新生血管的形成，这将有助于阐明视网膜新生血管疾病的可能机制和临床预防。结果表明，在遗传性视网膜色素变性小鼠模型中，Vldlr基因突变诱导的视网膜新生血管的发育受到抑制。这种现象的潜在机制归因于视网膜高氧状态下血管内皮生长因子表达水平的下调。这些结果为视网膜新生血管疾病的临床干预提供了依据。

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CLINICAL RESEARCH

Quantitative analysis of retinal intermediate and deep capillary plexus in patients with retinal deep vascular complex ischemia

Xin-Xin Li, Tian-Wei Qian, Ya-Nan Lyu, Xun Xu, Su-Qin Yu

The study aims to quantitatively analyze the retinal intermediate and deep capillary plexus (ICP and DCP) in patients with retinal deep vascular complex ischemia (RDVCI), using 3D projection artifacts removal optical coherence tomography angiography. The spectrum of retinal deep capillary vascular perfusion changes in RDVCI was characterized. The results show that the parafoveal vessel density of deep vascular complex, ICP and DCP in RDVCI is significantly decreased in both acute and chronic phases. Retinal ICP impairment is stabilized from acute to chronic phase in RDVCI, whereas subsequent DCP impairment is uncovered and can be explained by ischemia-reperfusion damage.

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视网膜深层血管复合体缺血患者视网膜中、深部毛细血管丛的定量分析

该研究旨在应用基于三维投影伪影去除的光学相干断层扫描血管成像技术定量分析视网膜深层血管复合体缺血患者视网膜中、深部毛细血管丛。观察视网膜深层血管复合体缺血时，其深部毛细血管灌注的变化。研究结果表明视网膜深层血管复合体缺血急性期和慢性期，深部血管复合体的中央凹旁血管密度，视网膜中、深部毛细血管丛密度均显著降低。视网膜中部毛细血管丛损伤从急性期到慢性期趋于稳定，而随后出现的深部毛细血管丛损伤，可能源于缺血-再灌注损伤。

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CLINICAL RESEARCH

Lag of accommodation predicts clinically significant change of spherical equivalents after cycloplegia

Cheng-Cheng Jin, Ru-Xia Pei, Bei Du, Gui-Hua Liu, Nan Jin, Lin Liu, Rui-Hua Wei

The article describes cycloplegic effects of cyclopentolate on 145 Chinese children aged from 4 to 15 years. It is proved for the first time that lag of accommodation plays a vital role in the change of spherical equivalent after cycloplegia, which predicted clinically significant cycloplegia by 82% (AUC=0.82) alone. Children with lag of accommodation below 1.15 D were likely to have hyperopic change over 0.50 D with high sensitivity (80%) and specificity (79%) after cycloplegia. This may help to reduce the waste of medical resources, promote the efficiency of diagnosis as well as improve the patient's medical experience.

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调节滞后预测睫状肌麻痹后等效球镜的显著变化

该文报道了环喷托酯对145例4～15岁儿童的睫状肌麻痹作用。首次证明了调节滞后在睫状肌麻痹后等效球镜的改变中起着重要作用，睫状肌麻痹临床独立预测效能达82%（AUC=0.82）。对于1.15 D以下的儿童，调节滞后可能带来0.50 D以上的远视改变，且在睫状肌麻痹后有较高的敏感性(80%)和特异性(79%)。这有助于减少医疗资源的浪费，提高诊断效率，改善患者的医疗体验。

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CLINICAL RESEARCH

The predictive value of pupillography on intraoperative floppy iris syndrome in preoperative period

Gozde Sahin Vural, Mehmet Vural

This study presented the frequency of intraoperative floppy iris syndrome (IFIS) in cataract patients who taking alpha 1-a receptor antagonist (ARA) drugs and evaluate the predictive value of pupil diameter (PD) changes in IFIS patients. The result shows that IFIS is a significant clinical syndrome with an increased intraoperative/postoperative complication ratio. The prediction of this syndrome is important because of prevention required precautions against possible complications. There is no association between IFIS and preoperative PD.

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术前瞳孔描记法对术中虹膜松弛综合征的预期值

该研究介绍了服用α1A受体拮抗剂的白内障患者术中虹膜松弛综合征的发生率，并评价了术中虹膜松弛综合征患者瞳孔直径变化的预期值。结果表明，术中虹膜松弛综合征是一种值得重视的临床综合征，可使术中/术后并发症发生率增高。术中虹膜松弛综合征的预测非常重要，这样可以针对可能的并发症采取预防措施，而术中虹膜松弛综合征与术前瞳孔直径并无关联。

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