BASIC RESEARCH

Therapeutic effect of a traditional Chinese medicine formulation on experimental choroidal neovascularization in mouse

Yu-Fei Zhang, Chuan Jiang, Xiao-Hong Zhou, Dong-Yu Wei, Shao-Heng Li, Pan Long, Man-Hong Li, Zuo-Ming Zhang, Tao Chen, Hong-Jun Du

The study aims to investigate therapeutic effects of traditional Chinese medicine formulations, Hexuemingmu (HXMM) on laser-induced choroidal neovascularization (CNV) and follow-up effect in mice. The electroretinogram, fundus fluorescence angiography, choroidal flat mount, and immunofluorescence staining were preformed to evaluate the function and CNV formation. The study confirmed that HXMM has a specific therapeutic effect on CNV in animal experiments. Its effect was mainly mediated by protecting the function of retinal cells, promoting the absorption of inflammatory exudation, and reducing the expression of related proteins. The results provide a new reference for the treatment of CNV-related diseases.

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中药制剂对小鼠实验性脉络膜新生血管的治疗作用

该研究旨在探讨中药制剂和血明目对激光诱导的小鼠脉络膜新生血管的治疗作用及随访效果。研究采用视网膜电图、眼底荧光血管造影、脉络膜铺片和免疫荧光染色评估视功能和脉络膜新生血管形成。该研究在动物实验中证实和血明目对脉络膜新生血管具有特异性治疗作用，其作用主要通过保护视网膜细胞功能、促进炎症渗出的吸收和降低相关蛋白的表达来实现。该研究结果为脉络膜新生血管相关疾病的治疗提供了新的参考。

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BASIC RESEARCH

Protective effect of LIF-huMSCs on the retina of diabetic model rats

Shan-Na Chen, Zhi-Gang Xu, Ying-Xue Ma, Song Chen, Guang-Hui He, Mei Han, Xiang Gao, Jun-Hua Wang, Bin Wu, Jian Wang

This study investigated the protective effect of human umbilical cord mesenchymal stem cells (hUCMSCs) modified by the LIF gene on the retinal function of diabetic model rats and preliminarily explore the possible mechanism. The results showed that an intravitreal injection of hUCMSCs, especially LIF-hUCMSCs, increased the levels of adiponectin (APN) and neurotrophin-4 (NT-4) and reduced the production of high-sensitivity C-reactive protein (hs-CRP). These findings suggest that hUCMSCs can improve retinal function in diabetic rats through immunomodulation and neurotrophic effects. The improvement is more obvious for LIF-hUCMSCs.

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LIF基因修饰的人脐带间充质干细胞对糖尿病大鼠模型视网膜的保护作用

该研究探讨了LIF基因修饰的人脐带间充质干细胞（LIF-hUCMSCs）对糖尿病大鼠模型视网膜功能的保护作用，并初步探讨了可能的机制。研究结果显示，玻璃体内注射hUCMSCs，尤其是LIF-hUCMSCs，可提高脂联素（APN）和神经营养因子-4（NT-4）的水平并减少高敏C反应蛋白（hs-CRP）的产生。这些结果表明hUCMSCs可以通过免疫调节和营养神经作用改善糖尿病大鼠的视网膜功能，并且LIF-hUCMSCs的改善更为明显。

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CLINICAL RESEARCH

Association of peripheral anterior synechia, intraocular pressure, and glaucomatous optic neuropathy in primary angle closure diseases

Ming Zhang, Guang-Yun Mao, Cong Ye, Su-Jie Fan, Yuan-Bo Liang, Ning-Li Wang

Glaucoma is the leading cause of irreversible blindness worldwide. This study aims to determine the association of peripheral anterior synechia (PAS) with raised intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in primary angle closure (PAC) disease. Totally 355 eyes of 181 patients were included in this analysis from a randomized clinical trial. The results indicate that PAS is linearly associated with the probability of GON and is of great clinical significance. Besides, the extent of PAS is an important predictor of higher IOP. In conclusion, PAS was significantly associated with IOP and GON in PAC diseases.

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原发性闭角型青光眼周边虹膜前粘连、眼内压与青光眼视神经损害的相关性

青光眼是世界范围内导致不可逆性失明的主要原因。该研究旨在探讨周边虹膜前粘连与眼内压升高和原发性闭角型青光眼视神经损害的患病率之间的相关性。研究采用随机临床试验方法，共纳入181例患者355只眼。结果表明，周边虹膜前粘连与发生青光眼视神经损害的概率呈线性相关，具有重要的临床意义。除此之外，周边虹膜前粘连的程度也是高眼内压的重要预测因子。综上所述，在原发性闭角型青光眼患者中周边虹膜前粘连与眼内压和青光眼视神经损害显著相关。

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REVIEW ARTICLE

Vitreous function and intervention of it with vitrectomy and other modalities

Yao Zong, Qian-Ying Gao, Yan-Nian Hui

The vitreous gel is the largest component structure of the eye and plays a key role in eye development, refraction, cell barrier, oxygen metabolism and retinal pathogenesis. However, intravitreal injections and vitrectomy have been widely used, sometimes overdone, and severely interfere with its structure and function. In the review, the function and oxygen metabolism of vitreous gel and intervention of it with vitrectomy and other modalities were emphasized, particularly the lens and trabecular meshwork from oxidative stress damage after vitrectomy and extraocular procedures for rhegmatogenous retinal detachment (RRD) in order to avoid vitreous intervention.

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玻璃体切除术及其它操作对玻璃体功能的干扰

玻璃体是眼部最大的组成结构，在眼部发育、屈光状态、细胞屏障、氧代谢和视网膜病变中起着关键作用。然而，玻璃体腔注射和玻璃体切除术的应用非常广泛，如果过度使用，会严重干扰玻璃体的结构和功能。该文介绍了玻璃体的功能、氧代谢，并强调了玻璃体切除术及其它操作对玻璃体功能的干扰，特别是玻璃体切除术后氧化应激对晶状体和小梁网的损伤，以及孔源性视网膜脱离外路手术可避免对玻璃体的干扰。

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